1.Up to Date on Astrocytes.
International Neurourology Journal 2018;22(Suppl 3):S104-S105
No abstract available.
Astrocytes*
2.Identification of Differentially Expressed Genes in Human Fetal Astrocytes.
Hye Myung YOO ; Hyun Sook PARK ; Hyun Chul CHO ; Choon Myung KOH ; Joo Young PARK
Journal of the Korean Society for Microbiology 2000;35(5):374-374
No Abstract Available.
Astrocytes*
;
Humans*
3.Establishment of a Culture Method and Characterization for Human Fetal Astrocytes.
Joo Young PARK ; Hye Myung RYU ; Sun Ju CHOI ; Hyun Sook PARK ; Choon Myung KOH ; Sung Soo LEE
Journal of Bacteriology and Virology 2001;31(1):39-45
No abstract available.
Astrocytes*
;
Humans*
4.Monitoring the Activity of Astrocytes in Learning and Memory.
Neuroscience Bulletin 2022;38(9):1117-1120
Astrocytes
;
Learning
;
Memory
6.Scavenger receptor on astrocytes and its relationship with neuroinflammation.
Liang-Yu WU ; Xiu-Qi BAO ; Hua SUN ; Dan ZHANG
Acta Academiae Medicinae Sinicae 2014;36(3):330-335
Neuroinflammation in central nervous system, featured by glial cells activation, can always be found during the development of neurodegenerative diseases. Astrocytes, the most abundant glial cells in the brain, can release both pro-inflammatory and anti-inflammatory factors, thus playing a crucial role in the neuroinflammation. A variety of pattern-recognition receptors on astrocytes are involve d in the inflammatory response, particularly the scavenger receptor. Scavenger receptor is a cell surface glycoprotein and can identify diverse ligands. With a variety of biological functions, it may activate many signal pathways related to neuroinflammation, regulate the host defense and the development of neuroinflammation, and eventually regulate the process of neuroinflammation. Thus, it play a key role in the development of neurodegenerative diseases and many other conditions. This review summarizes the scavenger receptor expressed on astrocytes and how it regulates signal transduction pathways associated with neuroinflammation and thus participates in regulating neuroinflammation.
Astrocytes
;
Humans
;
Neuritis
;
Receptors, Scavenger
7.Characterization of Gene Expression Pattern in Human Astrocytes using DDRT - PCR Method.
Hye Myung RYU ; Sun Ju CHOI ; Hyun Chul CHO ; Sung Soo LEE ; Choon Myung KOH ; Joo Young PARK
Journal of Bacteriology and Virology 2001;31(1):47-54
No abstract available.
Astrocytes*
;
Gene Expression*
;
Humans*
;
Polymerase Chain Reaction*
8.Orai1 and Orai3 in Combination with Stim1 Mediate the Majority of Store-operated Calcium Entry in Astrocytes.
Jea KWON ; Heeyoung AN ; Moonsun SA ; Joungha WON ; Jeong Im SHIN ; C Justin LEE
Experimental Neurobiology 2017;26(1):42-54
Astrocytes are non-excitable cells in the brain and their activity largely depends on the intracellular calcium (Ca²⁺) level. Therefore, maintaining the intracellular Ca²⁺ homeostasis is critical for proper functioning of astrocytes. One of the key regulatory mechanisms of Ca²⁺ homeostasis in astrocytes is the store-operated Ca²⁺ entry (SOCE). This process is mediated by a combination of the Ca²⁺-store-depletion-sensor, Stim, and the store-operated Ca²⁺-channels, Orai and TrpC families. Despite the existence of all those families in astrocytes, previous studies have provided conflicting results on the molecular identification of astrocytic SOCE. Here, using the shRNA-based gene-silencing approach and Ca²⁺-imaging from cultured mouse astrocytes, we report that Stim1 in combination with Orai1 and Orai3 contribute to the major portion of astrocytic SOCE. Gene-silencing of Stim1 showed a 79.2% reduction of SOCE, indicating that Stim1 is the major Ca²⁺-store-depletion-sensor. Further gene-silencing showed that Orai1, Orai2, Orai3, and TrpC1 contribute to SOCE by 35.7%, 20.3%, 26.8% and 12.2%, respectively. Simultaneous gene-silencing of all three Orai subtypes exhibited a 67.6% reduction of SOCE. Based on the detailed population analysis, we predict that Orai1 and Orai3 are expressed in astrocytes with a large SOCE, whereas TrpC1 is exclusively expressed in astrocytes with a small SOCE. This analytical approach allows us to identify the store operated channel (SOC) subtype in each cell by the degree of SOCE. Our results propose that Stim1 in combination with Orai1 and Orai3 are the major molecular components of astrocytic SOCE under various physiological and pathological conditions.
Animals
;
Astrocytes*
;
Brain
;
Calcium*
;
Homeostasis
;
Humans
;
Mice
9.Role of astrocyte in pathogenesis of epilepsy.
Journal of Zhejiang University. Medical sciences 2013;42(3):245-252
Astrocytes
;
metabolism
;
pathology
;
Epilepsy
;
pathology
;
Humans
10.Astrocyte-Mediated Myelin Phagocytosis in Ischemia.
Luodan YANG ; Dongyu ZHANG ; Quanguang ZHANG
Neuroscience Bulletin 2023;39(1):167-169
Humans
;
Myelin Sheath
;
Astrocytes
;
Phagocytosis
;
Macrophages
;
Ischemia