Background:Asthma is a chronic infectious disease of respiratory which affect to health, study, labor and social activities. It can be occur at all age, the rate of incidence of this disease and mortality is increasing. Objectives:This study aims to learn about the clinical features and treatment results in children with asthma admitted into pediatric department, Thai nguyen Central Hospital. Subjects and method: A retrospective study was carried out on 65 asthma children who admitted to Asthma children of Department of Pediatrics, Thai Nguyen Central hospital in order to find the frequency, risks factor, clinical and management ofasthma from 1st January 2004 to 31st December 2006. Results:The asthma rate was 0.81 % among total inpatients and 2.87% among total patients admitted into the Respiratory Department. 30.8% of patients aged from 3 to 6 years old without sex predominance. The children were admitted more often in April, May, September, October and November. Personal and family history of asthma was seen in 70.77% and 35.38%, respectively. The common signs were: cough in 93.9%, coryza in 89.2%, intercostal retraction in 87.7%, wheezing in 80.0%, dyspnea in 66.2%. 4. Management: Bronchodilatator in 100%, antibiotics in 95.4%, corticoid in 76.9%. Improvement was seen in 98.5% and death in 54%. Conclusion: Drugs to lessen cough, phlegm and infusion were not encourage in asthma treatment.
Asthma/ pathology ; therapy ; Child

Background:Asthma is a chronic disease. Its characteristic is a chronic process of infection on respiratory leading to obstructed respiratory airway. In order to evaluate the obstructed respiratory disorder on asthma children, there are many various methods in which two methods are been applied widely: measure respiratory function and measure the resistance of respiratory airway. Objectives:This study aims to learn aboutthe respiratory airway resistance of asthmatic children from 6 to 10 years old at Respiratory Department of Saint-Paul hospital. Subjects and method: A retrospective, cross sectional and descriptive study was conducted on 135 children with asthma hospitalized at the Pulmonary Division at the Hospital Saint - Paul from January to October 2006. Results:- Value through thoracic pulmonary resistance in children asthmatics:The average resistance of the respiratory tract had inspiration: 7.31 \xb1 2.14 hPa.s L -1 . The average resistance of the respiratory tract had expiration: 8.30 \xb1 2.42 hPa.s L -1. There was no significant difference in the resistance of the respiratory tract between boy and girl children. Conclusion: Thoracic pulmonary resistance decreased with age from 6 to 10 years. After the inspiration of Ventolin, resistance of the respiratory tract decreased of 22.2% in the inspiration and 17.5 in expiration. The difference was significant.
Asthma/ pathology ; therapy ; Child

Asthma ; diagnosis ; pathology ; Humans

Airway Remodeling ; Asthma ; pathology ; physiopathology ; Child ; Humans

Asthma ; pathology ; Basophils ; physiology ; Bronchi ; pathology ; Humans ; Neutrophils ; physiology

Bronchial asthma is a heterogeneous chronic inflammatory disease involving multiple immune cells and structural cells.It is characterized by airflow limitation,airway hyperresponsiveness,and airway remodeling,with complex pathogenesis.In recent years,the research on exosomes has developed rapidly.Exosomes are small vesicles secreted by a variety of cells and are naturally found in various biological fluids,with stability and biocompatibility.Exosomes from different cells are involved in pathophysiological processes such as airway inflammation,remodeling,and hyperresponsiveness through specific mechanisms and play a regulatory role in multiple links in bronchial asthma.This review focuses on the role of exosomes from different cells in the pathogenesis of bronchial asthma.
Humans ; Exosomes/pathology* ; Asthma ; Lung/pathology* ; Inflammation ; Chronic Disease

PURPOSE: Airway pathology in children with atopic asthma can be reflected by the concave shape of the maximal expiratory flow-volume (MEFV) curve and high fractional exhaled nitric oxide (FeNO) values. We evaluated the capacity of the curvilinearity of the MEFV curve, FeNO, and their combination to distinguish subjects with atopic asthma from healthy individuals. METHODS: FeNO and angle β, which characterizes the general configuration of the MEFV curve, were determined in 119 steroid-naïve individuals with atopic asthma aged 8 to 16 years, and in 92 age-matched healthy controls. Receiver operating characteristic (ROC) curve analyses were performed to determine the cutoff points of FeNO and angle β that provided the best combination of sensitivity and specificity for asthma detection. RESULTS: Asthmatic patients had a significantly smaller angle β and higher FeNO compared with healthy controls (both, P<0.001). For asthma detection, the best cutoff values of angle β and FeNO were observed at 189.3° and 22 parts per billion, respectively. The area under the ROC curve for the combination of angle β and FeNO improved to 0.91 (95% confidence interval [CI], 0.87–0.95) from 0.80 (95% CI, 0.75–0.86; P<0.001) for angle β alone and 0.86 (95% CI, 0.82–0.91; P=0.002) for FeNO alone. In addition, the combination enhanced sensitivity with no significant decrease in specificity. CONCLUSION: These data suggest that the combined use of the curvilinearity of the MEFV curve and FeNO is a useful tool to differentiate between children with and without atopic asthma.
Asthma* ; Child* ; Humans ; Nitric Oxide* ; Pathology ; ROC Curve ; Sensitivity and Specificity

Asthma, Occupational ; etiology ; pathology ; Humans ; Inflammation ; pathology ; Neutrophil Infiltration ; Neutrophils ; pathology

Eosinophils are important immune cells that contain eosinophilic particles and play a key role in allergic diseases such as asthma and helminth infections. An increasing number of studies have confirmed that eosinophils infiltrate a variety of tumor tissues, which can synthesize and secrete a large number of bioactive substances under certain circumstances, such as cytotoxic cationic proteins, cytokines, growth factors, chemokines, enzymes and so on, which may affect angiogenesis and matrix remodeling or change the tumor microenvironment, thereby affecting tumor progression. This review focused on the role of eosinophils in lung cancer and provided an outlook on the issues in clinical and basic research.
Humans ; Eosinophils/pathology* ; Lung Neoplasms ; Cytokines ; Hypersensitivity/pathology* ; Asthma/pathology* ; Tumor Microenvironment

Eosinophils are important immune cells that contain eosinophilic particles and play a key role in allergic diseases such as asthma and helminth infections. An increasing number of studies have confirmed that eosinophils infiltrate a variety of tumor tissues, which can synthesize and secrete a large number of bioactive substances under certain circumstances, such as cytotoxic cationic proteins, cytokines, growth factors, chemokines, enzymes and so on, which may affect angiogenesis and matrix remodeling or change the tumor microenvironment, thereby affecting tumor progression. This review focused on the role of eosinophils in lung cancer and provided an outlook on the issues in clinical and basic research.
Humans ; Eosinophils/pathology* ; Lung Neoplasms ; Cytokines ; Hypersensitivity/pathology* ; Asthma/pathology* ; Tumor Microenvironment