Pulmonary aspergillosis is the most common disease of fungal infection and has lower infectivity. Pulmonary aspergillosis is classified by aspergilloma, bronchopulmonary aspergillosis, necrotic and invasive aspergillosis. Invasive aspergillosis is found in immune compromised host, immunosuppressive treatment after organ transplantation, anticancerous chemotherapy, blood abnormality, AIDS patients etc. We reported a case of invasive aspergillosis in an immunocompetent host, with review of literatures.
Aspergillosis ; Drug Therapy ; Humans ; Invasive Pulmonary Aspergillosis* ; Organ Transplantation ; Pulmonary Aspergillosis ; Spinal Cord ; Spine* ; Transplants

Aspergillosis ; Humans ; Mucor ; Mucormycosis/drug therapy*

Aspergillosis, Allergic Bronchopulmonary ; diagnosis ; drug therapy ; Child ; Humans ; Male

Aspergillosis ; diagnosis ; drug therapy ; Child, Preschool ; Female ; Humans ; Infant ; Lung Diseases, Fungal ; diagnosis ; drug therapy ; Male

The mortality rate of the invasive pulmonary aspergillosis to be able to developed during chemotherapy induced myleosuppressionin is high in hematologic malignancy patients despite antifungal treatment. Effective antifungal treatment combined with operation can decrease the mortaligy rate of the invasive pulmonary aspergillosis. Recently, we experienced the successful management of the two cases of invasive pulmonary aspergillosis in acute lymphoblastic leukemia through effective antifungal treatment and surgical resection. We report this cases with review of literature.
Drug Therapy ; Hematologic Neoplasms ; Hematology ; Humans ; Invasive Pulmonary Aspergillosis* ; Mortality ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Pulmonary Aspergillosis

Most primary spinal abscesses, irrespective of pathogens and anatomical locations, have better prognosis than that of secondary abscesses with spondylitis. We report a 68-year-old man, previously undertaken pulmonary resection due to tuberculosis, presented with paraparesis. Imaging studies showed primary intraspinal abscesses at T-1 and T-3 vertebral levels, semi-invasive pulmonary Aspergillosis and inflammation of the posterior mediastinum. Operative procedure and histopathological examination revealed interdural Aspergillus abscess. Despite chemotherapy, he deteriorated progressively, and spondylitis developed at corresponding vertebrae. He eventually died 6 weeks postoperatively due to pulmonary complication. The authors intended to inform that such an extradural inflammatory lesion of Aspergillus abscess should be treated carefully.
Abscess* ; Aged ; Aspergillosis ; Aspergillus* ; Drug Therapy ; Humans ; Inflammation ; Mediastinitis* ; Mediastinum ; Paraparesis ; Prognosis ; Pulmonary Aspergillosis ; Spine ; Spondylitis* ; Surgical Procedures, Operative ; Tuberculosis

We report a case of Aspergillus terreus discitis which developed in a patient with acute lymphoblastic leukemia following induction chemotherapy. A. terreus was isolated from sputum, one month earlier, but the physician did not consider it significant at the time. Magnetic resonance imaging study showed the involvement of L3-4, L4-5 and L5-S1 intervertebral discs. Etiology was established by means of histology and culturing a surgical specimen of disc materials. Our patient survived after a surgical debridement and amphotericin B administration with a total dose of 2.0 g. Discitis caused by Aspergillus terreus is a very rare event. A. terreus is one of the invasive Aspergillus species. The pathogenetic mechanism is discussed and the literature is reviewed.
Aspergillosis/surgery ; Aspergillosis/pathology ; Aspergillosis/microbiology* ; Aspergillosis/drug therapy ; Aspergillosis/complications ; Aspergillus/isolation & purification ; Aspergillus/classification ; Journal Article ; Discitis/surgery ; Discitis/pathology ; Discitis/microbiology* ; Discitis/drug therapy ; Human ; Intervertebral Disk/surgery ; Intervertebral Disk/pathology ; Intervertebral Disk/microbiology* ; Leukemia, Lymphocytic, Acute/microbiology ; Leukemia, Lymphocytic, Acute/drug therapy ; Leukemia, Lymphocytic, Acute/complications* ; Lumbar Vertebrae/surgery ; Lumbar Vertebrae/pathology ; Lumbar Vertebrae/microbiology*

Aspergillus species are primarily pulmonary pathogens but can involve extra-pulmonary organs by angioinvasive properties. Isolated renal aspergillosis is extremely rare even among the immunocompromised patients. Recently, we experienced a case of isolated renal aspergillosis presenting gross hematuria and renal mass-like lesion in a patient with acute myelocytic leukemia, who was treated with systemic amphotericin B and oral itraconazole after nephrectomy. To our knowledge, this is the first report of isolated renal aspergillosis in a patient with acute leukemia receiving chemotherapy. Here, we report this case with a review of literature.
Amphotericin B ; Aspergillosis* ; Aspergillus ; Drug Therapy ; Hematuria ; Humans ; Immunocompromised Host ; Itraconazole ; Leukemia ; Leukemia, Myeloid, Acute* ; Nephrectomy

Cerebral aspergillosis is a rare condition, and like other opportunistic fungal infections, it most commonly occurs in immunocompromised patients. Because of the increasing use of chemotherapy in organ transplanta-tion, cases involving neoplasms, corticosteroid therapy, and cases of lymphoma and leukemia, the incidence of fungal infections in the brain has recently increased. Cerebral aspergillosis in an infant with normal immunity is a very rare condition, and has not been reported in Korea. We report the MR findings of this condition in an infant with normal immunity.
Aspergillosis* ; Brain ; Drug Therapy ; Humans ; Immunocompromised Host ; Incidence ; Infant* ; Korea ; Leukemia ; Lymphoma ; Magnetic Resonance Imaging*

OBJECTIVES: Aspergillosis of central nervous system(CNS) is a rare pathologic condition and it has been known to be difficult to diagnose and treat. We analyzed seven cases of central nervous system aspergillosis. The clinical characteristics, and the problems in diagnosis and treatment are discussed with review of previous literatures. MATERIALS AND METHODS: We reviewed the clinical records, radiological findings, and pathologic reports of 7 patients with aspergillosis which involved CNS. RESULTS: Five patients were immunocompetent, and infection was related with previous operation in 4 of them. Two patients were immunocompromised and had no history of operation. Five patients had intracranial lesions and two had spinal lesions. Mean duration from the onset of initial symptom to pathologic diagnosis was 2.4 months. Mean duration from the previous operation to the onset of symptom was 9.3 months, and from the onset of symptom to diagnosis was 2.9 months in the patients who had histories of operation. All of them were treated with surgical procedures and intravenous and oral antifungal agents, resulting in cure in 6 cases. Mean duration of the treatment was 4.9 months. CONCLUSION: Because aspergillosis of CNS is a rare disease and is difficult to be differentiated from the pyogenic abscess or recurrent tumor, the pathologic diagnosis is very important for adequate treatment. Although the prognosis of aspergillosis of CNS has been known to be poor, adequate surgery for both diagnosis and treatment and antifungal chemotherapy resulted in good outcome.
Abscess ; Antifungal Agents ; Aspergillosis* ; Central Nervous System* ; Diagnosis ; Drug Therapy ; Humans ; Prognosis ; Rare Diseases