1.Rhinocerebral mucormycosis: report of two cases.
Chun-yan HE ; Yu-lan JIN ; Hong-gang LIU
Chinese Journal of Pathology 2010;39(5):345-346
Adolescent
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Aged
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Aspergillosis
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microbiology
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pathology
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Aspergillus
;
isolation & purification
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Brain Diseases
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drug therapy
;
microbiology
;
pathology
;
surgery
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Diabetes Complications
;
microbiology
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Diagnosis, Differential
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Female
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Humans
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Male
;
Mucorales
;
isolation & purification
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Mucormycosis
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drug therapy
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pathology
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surgery
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Nose Diseases
;
drug therapy
;
microbiology
;
pathology
;
surgery
2.Invasive Primary Colonic Aspergillosis in the Immunocompetent Host without Classical Risk Factors.
Seon Ah CHA ; Mi Hee KIM ; Tae Seok LIM ; Hyun Ho KIM ; Kyung Yoon CHANG ; Hoon Suk PARK ; Hyung Wook KIM ; Seong Heon WIE ; Dong Chan JIN
Yonsei Medical Journal 2015;56(5):1453-1456
Invasive aspergillosis (IA), generally considered an opportunistic infection in immunocompromised hosts, is associated with high morbidity and mortality. IA commonly occurs in the respiratory tract with isolated reports of aspergillosis infection in the nasal sinuses, central nervous system, skin, liver, and urinary tract. Extra-pulmonary aspergillosis is usually observed in disseminated disease. To date, there are a few studies regarding primary and disseminated gastrointestinal (GI) aspergillosis in immunocompromised hosts. Only a few cases of primary GI aspergillosis in non-immunocompromised hosts have been reported; of these, almost all of them involved the upper GI tract. We describe a very rare case of IA involving the lower GI tract in the patient without classical risk factors that presented as multiple colon perforations and was successfully treated by surgery and antifungal treatment. We also review related literature and discuss the characteristics and risk factors of IA in the immunocompetent hosts without classical risk factors. This case that shows IA should be considered in critically ill patients, and that primary lower GI aspergillosis may also occur in the immunocompetent hosts without classical risk factors.
Amphotericin B/administration & dosage/therapeutic use
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Antifungal Agents/administration & dosage/*therapeutic use
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Aspergillosis/*diagnosis/drug therapy/microbiology/surgery
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Aspergillus/*isolation & purification
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Colon/microbiology/radiography/*surgery
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Colonic Diseases/diagnosis/therapy
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Combined Modality Therapy
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Humans
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*Immunocompetence
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Laparotomy
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Male
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Middle Aged
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Treatment Outcome
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Voriconazole/administration & dosage/therapeutic use
3.Surgical Treatment of Native Valve Aspergillus Endocarditis and Fungemic Vascular Complications.
Kyoung Min RYU ; Pil Won SEO ; Sam Hyun KIM ; Seongsik PARK ; Jae Wook RYU
Journal of Korean Medical Science 2009;24(1):170-172
Systemic infection with Aspergillus is an opportunistic disease that affects mainly immunocompromised hosts, and is associated with a high mortality rate. It typically occurs in patients with several predisposing factors, but Aspergillus endocarditis of native valves is rare and experience in diagnosis and treatment is limited. We report a case of native valve endocarditis caused by Aspergillus. A 35-yr-old male patient who underwent pericardiocentesis four months previously for pericardial effusion of unknown etiology presented with right leg pain and absence of the right femoral artery pulse. Cardiac echocardiography revealed severe mitral insufficiency with large mobile vegetations, and computed tomographic angiography showed embolic occlusion of both common iliac arteries. We performed mitral valve replacement and thromoembolectomy, and Aspergillus was identified as the vegetation. We started intravenous amphotericin B and oral itraconazole, but systemic complications developed including superior mesenteric artery aneurysm and gastrointestinal bleeding. After aggressive management, the patient was discharged 78 days post surgery on oral itraconazole. He was well at 12 months post discharge but died in a traffic accident 13 months after discharge.
Administration, Oral
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Adult
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Amphotericin B/administration & dosage
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Antifungal Agents/administration & dosage
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Aspergillosis/complications/*diagnosis/drug therapy
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Aspergillus/isolation & purification
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Endocarditis/*diagnosis/surgery/ultrasonography
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Heart Valve Diseases/*diagnosis/microbiology/surgery
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Humans
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Itraconazole/administration & dosage
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Male
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Postoperative Complications/microbiology
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Tomography, X-Ray Computed