1.Epithelioid hemangioma of distal femoral epiphysis in a patientwith congenital talipes equinovarus
Asit Ranjan Mridha ; Prateek Kinra ; Mukund Sable ; Meher Chand Sharma ; Shishir Rastogi ; Shah Alam Khan ; Shivanand Gamanagatti
The Malaysian Journal of Pathology 2014;36(1):63-66
Epithelioid hemangioma (EH) is a rare benign vascular lesion of soft tissue and bone,
characterized by endothelial cells with epithelioid or histiocytoid appearance. Though tubular bones,
flat bones, vertebra and short bones are common sites for this lesion, the epiphyseal involvement
is extremely rare. We present an unusual case of EH of the distal femur in a young boy. Case
report: A 12-year-old boy who had congenital talipes equinovarus of the right foot presented with
progressively increasing pain in the right lower thigh for six months. Physical examination revealed
muscular atrophy of the right lower limb and a moderately tender swelling in the medial aspect
of the right knee without restriction of knee movement. An X-ray revealed an osteolytic lesion,
which appeared iso- and hypointense on T1W and hyperintense on T2W MRI images in the distal
epiphysis and adjacent metaphysis of the right femur. A radiological diagnosis of chondroblastoma
was entertained. The patient was treated with curettage and bone grafting. Histopathology showed a
tumor composed of thin-walled arteriolar capillaries lined by large, polyhedral epithelioid endothelial
cells with vesicular nuclei, finely distributed nuclear chromatin, and moderate amount of eosinophilic
cytoplasm. The endothelial cells were strongly immunopositive for CD34. Mitotic activity was
low and the Ki-67 proliferative rate was <2%. A diagnosis of EH was made. EH is a benign
lesion and it should be differentiated from its histologically similar malignant counterparts such as
epithelioid hemangioendothelioma and epithelioid angiosarcoma as the lesion can be successfully
treated with curettage or resection.
2.Angiomyomatous Hamartoma of Popliteal Lymph Node: An Unusual Entity.
Asit Ranjan MRIDHA ; Richa RANJAN ; Prateek KINRA ; Ruma RAY ; Shah Alam KHAN ; Gamanagatti SHIVANAND
Journal of Pathology and Translational Medicine 2015;49(2):156-158
No abstract available.
Hamartoma*
;
Lymph Nodes*
3.Focal Hematopoietic Hyperplasia of Rib: A Rare Pseudotumor and Review of Literature.
Maneesh VIJAY ; Asit Ranjan MRIDHA ; Ruma RAY ; Prateek KINRA ; Biplab MISHRA ; H S CHANDRASHEKHAR
Journal of Pathology and Translational Medicine 2015;49(2):159-162
No abstract available.
Hyperplasia*
;
Ribs*
4.Morphological Changes in the Ligamentum Flavum in Degenerative Lumbar Canal Stenosis: A Prospective, Comparative Study
Devanand HULMANI ; Bhavuk GARG ; Nishank MEHTA ; Asit Ranjan MRIDHA ; Tapas Chandra NAG ; Kamran FAROOQUE
Asian Spine Journal 2020;14(6):773-781
Methods:
Forty patients were prospectively recruited and divided into two groups: group 1 included 20 patients with degenerative LCS aged >55 years and group 2 included patients with LDH aged <35 years. The ligament flava were collected during the patients’ surgery. The features noted on histopathological examination included the fibrosis score, the loss of elastic fibers, calcification, chondroid metaplasia, mucinous degeneration, vascularization, long septa, clefts, granulation tissue, and ganglion-like cysts. The features noted on electron microscopic examination included the elastic fiber thickness, the quality of elastic fibers, the elastic:collagen ratio, calcification, melanin fibers, remnants of necrotic cells, and electron-dense material in the LF. All parameters were compared between group 1 and group 2.
Results:
On histopathological examination, the two groups exhibited significant differences regarding three parameters: chondroid metaplasia, long septa, and ganglion-like cysts. On electron microscopy examination, significant differences were observed between the two groups regarding two parameters: the quality of elastic fibers and the elastic:collagen ratio.
Conclusions
Characteristic morphological changes may be noted on histopathological and electron microscopic examination that mark the degenerative changes in the LF that contribute to the occurrence and pathogenesis of degenerative LCS.