INTRODUCTION: This study aimed to compare the effectiveness of immature Magnifera indica L. (mango) fruit with albendazole in reducing Ascaris lumbricoides infection among children. METHODS: Children aged 2 to 14 years were enrolled in a randomized, controlled, non-inferiority trial. Participants were randomly allocated to receive 250 mL immature mango fruit puree daily for 3 days or one dose of albendazole 400 mg tablet. Egg reduction rates and cure rates were computed and compared. Adverse effects were monitored during and after administration of treatment. RESULTS: There was a statistically significant decrease between the pre- and post-treatment EPG of those who took immature mango fruit (p < 0.001) and those who took albendazole (p < 0.001). There was a higher ERR and CR for the albendazole group, but the difference was not significant (p = 0.472, p = 785, respectively). Risk analysis of reduction in intensity showed mango is non-inferior to albendazole (RR = 0.80, 95% CI 0.67, 0.97; p = 0.026). Risk analysis of cure showed mango is noninferior to albendazole in both PP (RR = 0.92, 95% CI 0.68, 1.25; p = 0.607) and ITT (RR=0.79, 95% CI 0.58, 1.08; p = 0.139). CONCLUSION Immature Mangifera indica Linn is non-inferior to albendazole in terms of effectiveness in the reduction of ascariasis infection.
Ascariasis

An investigation was conducted on 101 cases of biliary calculus. Results show a rate of 17.82% of bile duct ascariasis, from them 75% with ascaris found in the large duct and 75% died. 33% of cases had experienced a previous history of bile duct ascariasis. Bile culture had indicated a positive rate of 81.25% of aerobic bacteria and 4/6 of anaerobic.
Ascariasis ; Gallstones

The ascaris is a major cause of pancreatitis in children. A study on 60 pediatric patients with the pancreatitis due to ascaris was implemented. It should be regarded the pancreatitis when patients with symptoms of the acute abdominal pain, vomiting, especially vomiting fluid containing ascaris or in pediatric patients diagnosed as biliary ascarisis, uncompleted verminous ileus. The tests of blood amylase, urinary amylase and ultrasound should be considered.
Pancreatitis ; Ascariasis ; Child

The biliary ascariasis and bilo-pancreatic ascasis is a series of the biliary-liver diseases in Vietnam. Endoscopic worm removal is high effective. Study on 24 case with BA or BPA from 5/1997 to 6/1998 at Viet Duc Hospital, these patients were treated the worm removal by endoscope. Result shown that it is economic, effective new method. It required closely cooperation between clinical doctor and ultrasound, endoscope's doctor. Some factors related with biliary ascariasis like women, pregnancy, farmer, summer. When people have signs of BA and BPA, should endoscope to removal of worms.
Ascariasis ; endoscopy ; therapeutics ; surgery

Between 1990 to 1994, 217 patients were diagnosed with biliary ascariasis by ultrasonography. It was showed that biliary ascariasis is a pathological condition with excess incidence. Treatment in complicated or pregnant cases is difficult and costly. Some factors, especially female gender, pregnancy, and pH level of biliary fluid can influence favorably to the migration of ascarid. Ascarid infection density does not affect to the relapse frequency. Use helminthics early with single dose can provide the pain relief rapidly, reduce the rate of complication and avoid overuse the anti-spasmodics. The patients with history of biliary asariasis relapses should be followed-up and treated actively.
Ascariasis ; ultrasonography ; therapeutics

The study aims to identify the rate of pregnancy patients in childbearing-age female who have biliary ascariasis. Fetal abnormalities have not found. Complications as biliary infection, acute pancreatitis and pancreatic reactions were observed.
Ascariasis ; pregnancy ; pregnant women

A study on 126 patients with biliary ascariasis (female/male: 4/1) in December 1997 in Hue Central Hospital has shown that the disease is initiated suddenly with severe pain in the right subcostal area and right chest (most common), vomiting, icterus, history of disease (80%). The common complications are bile duct infection, acute gallbladder infection, pancreatic reactions, acute pancreatitis, bile duct haemorrhage, bile duct abscess. Drugs: Pyrantil, antibiotics.
Ascariasis ; diagnosis ; therapy ; therapeutics

The present study was undertaken to determine whether an analysis of the collected worms after chemotherapy with pyrantel pamoate could be used as a method measuring the amount of reinfection of Ascaris lumbricoides in a given population. A total of 398 cases from two villages and one primary school were treated with pyrantel pamoate with dose of 10 mg/kg of body weight. The whole two-day stool specimens after treatment were examined. Out of 279 followed cases, 110 cases (39.4%) were found infected with A. lumbricoides. A total of 527 worms were collected, they were in the range of 1.2 to 32.5 cm in length and 0.0004 to 7.424 gm in weight. The measurements were made on the specimens fixed with 10% formalin. The relationship between the number of worms per positive case(X) and the total weight of worms(Y) showed the positive linear regression; this was expressed by the equation, Y= 2.012X + 1.135 (Sy=4.84, r=0.92). From the above results, it seems that worms of small size may not be considered as a product of crowding effect in heavy infections. The relation between the weight(Y) and length(X) of collected A. lumbricoides was expressed as an equation, Log(e)Y=3.032 log(e)X-8.2903(S.E. of reg. coeff.= 0.040, r=0.957). In the intestinal phase of development, the first increase of the length of the worm, up to 10-12 cm was observed and this followed by the well marked increase of weight from 13 cm upto 32.5 cm in the sexually maturing phase. A total of 285 schoolchildren were treated by pyrantel pamoate, 10 mg/kg of body weight three times each in two months interval. After the second and third treatment, thirteen and fifty-four worms were collected respectively. They were measured in length and weight and were all in the range of 1.2 to 13.2 cm in length and 0.0006 to 0.436 gm in weight except 3 fully matured adults. It is assumed that these young worms, defined as those less than 0.5 gm in weight and less than 13 cm in length should be regarded as those having reinfected during the previous two months period. From this observation, it was possible to calculate the reinfected number of young worms. Therefore, it is suggested that the average number of Ascaris per month per person means the reinfection amount in a certain period of time in an endemic area of A. lumbricoides. In other words, reinfection amount may be expressed by the calculated figure of young worms reinfected in a certain period of time in a population.
parasitology-helminth-nematoda ; Ascaris lumbricoides ; ascariasis ; epidemiology-reinfection ; pyrantel pamoate

A 41-year-old woman liked farm chemical-free (pesticid-free) vegetables. She was admitted for severe upper abdominal pain. Biliary ascariasis was suspected upon abdominal ultrasonographic examination. ERC (Endoscopic Retrograde Cholangiography) was performed and a linear filling defect was shown in the bile duct. We diagnosed her case as biliary ascariasis. And then, we removed a worm from the bile duct using stone extracer basket forceps. After this, she was given pyrantel pamoate.Abdominal ultrasonographic examination was helpful in diagnostic screening for biliary ascariasis. ERC and basket forceps were useful in removing the parasite.
Biliary ; Ascariasis ; success ; Manufactured aid ; Endoscopic retrograde cholangiography

Chewable pyrantel pamoate tablets were administered to children randomly assigned to three treatment groups. Individuals in each group were instructed either to swallow whole, to chew and swallow, or to swallow previously pulverized tablets. With respect to Ascaris, results of posttreatment stool examinations indicated no differences in cure rates and egg reduction rates between the different modes of treatment. However, for both hookworm and Trichuris, mean egg counts increased for both swallow and chew groups, but decreased in the pulverized group. In addition to the highest egg reduction rates, the most parasitological cures were also seen in the pulverized group for these two worms. The status of standards for chewable tablets is discussed. Until the standards are changed it is recommended that all chewable tablets be crushed before swallowing.
Adolescent, Ascariasis - drug therapy, Hookworm Infections - drug therapy