2.Rhupus syndrome.
Jae Ki MIN ; Kyoung Ann LEE ; Hae Rim KIM ; Ho Youn KIM ; Sang Heon LEE
The Korean Journal of Internal Medicine 2015;30(1):131-131
No abstract available.
Antirheumatic Agents/therapeutic use
;
Arthritis, Rheumatoid/blood/*complications/diagnosis/drug therapy/physiopathology
;
Biological Markers/blood
;
Drug Therapy, Combination
;
Facial Dermatoses/complications/diagnosis
;
Female
;
Hand Joints/physiopathology/radiography
;
Humans
;
Immunosuppressive Agents/therapeutic use
;
Inflammation Mediators/blood
;
Knee Joint/physiopathology/radiography
;
Lupus Erythematosus, Systemic/blood/*complications/diagnosis/drug therapy
;
Middle Aged
;
Syndrome
;
Treatment Outcome
3.An under-recognized cause of polyarthritis: leprosy.
Khor Jia KER ; Jiun Yit PAN ; Nai Lee LUI ; Hong Liang TEY
Annals of the Academy of Medicine, Singapore 2013;42(7):366-367
Anti-Inflammatory Agents
;
administration & dosage
;
Arthritis
;
diagnosis
;
drug therapy
;
etiology
;
physiopathology
;
Arthritis, Rheumatoid
;
diagnosis
;
Clofazimine
;
administration & dosage
;
Dapsone
;
administration & dosage
;
Delayed Diagnosis
;
Diagnosis, Differential
;
Humans
;
Leprostatic Agents
;
administration & dosage
;
Leprosy
;
complications
;
diagnosis
;
drug therapy
;
physiopathology
;
Male
;
Middle Aged
;
Prednisolone
;
administration & dosage
;
Rifampin
;
administration & dosage
;
Treatment Outcome
4.The Effects of Rituximab on Lipids, Arterial Stiffness and Carotid Intima-Media Thickness in Rheumatoid Arthritis.
Diana S NOVIKOVA ; Tatiana V POPKOVA ; Galina V LUKINA ; Elena L LUCHIKHINA ; Dmitry E KARATEEV ; Alexander V VOLKOV ; Alexander A NOVIKOV ; Elena N ALEKSANDROVA ; Evgeny L NASONOV
Journal of Korean Medical Science 2016;31(2):202-207
The aim of the study was to examine lipid profiles, arterial stiffness (AS), carotid intima-media thickness (cIMT), in 55 women with RA without overt cardiovascular disease (capital ES, CyrillicVD) treated with rituximab (RTX).The following parameters were recorded before and 24 weeks after RTX therapy (2 infusions of 500 or 1,000 mg RTX intravenously, fortnightly): plasma total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides, DAS 28-ESR, serum C-reactive protein (CRP), RF IgM, AS (SI - stiffness index, RI - reflection index) by digital volume pulse contour analysis (Micro Medical, UK), and common cIMT by high-resolution B-mode carotid ultrasound. Based on the European League Against Rheumatism (EULAR) criteria, patients were divided into two groups: 1) moderate/good response to RTX therapy after 24 weeks (41 patients, 75%), 2) no response to RTX therapy (14 patients, 25%). Effective RTX therapy resulted in 9% increase in TC, 23% increase in HDL-C and 14% decrease in atherogenic index, 57% decrease in SI and 24% decrease in RI. We observed a 9% decrease of cIMTmax at 24 weeks. The improvement of cardiovascular parameters was accompanied by statistically significant decreases of CRP, ESR, RF IgM and DAS 28 in group 1 (P < 0.05). There were not significant changes in lipid profile, AS parameters, and cIMT in group 2. Two infusions of RTX in case of moderate/good EULAR effect of therapy exerted favorable effects on lipid profile, AS and cIMT in women with RA without overt CVD.
Antirheumatic Agents/*therapeutic use
;
Arthritis, Rheumatoid/complications/*drug therapy/physiopathology
;
Biomarkers/blood
;
C-Reactive Protein/analysis
;
Cardiovascular Diseases/complications
;
Carotid Intima-Media Thickness
;
Cholesterol, HDL/blood
;
Cholesterol, LDL/blood
;
Female
;
Humans
;
Lipids/*blood
;
Middle Aged
;
Rituximab/*therapeutic use
;
Treatment Outcome
;
Triglycerides/blood
;
Vascular Stiffness
5.The Effects of Rituximab on Lipids, Arterial Stiffness and Carotid Intima-Media Thickness in Rheumatoid Arthritis.
Diana S NOVIKOVA ; Tatiana V POPKOVA ; Galina V LUKINA ; Elena L LUCHIKHINA ; Dmitry E KARATEEV ; Alexander V VOLKOV ; Alexander A NOVIKOV ; Elena N ALEKSANDROVA ; Evgeny L NASONOV
Journal of Korean Medical Science 2016;31(2):202-207
The aim of the study was to examine lipid profiles, arterial stiffness (AS), carotid intima-media thickness (cIMT), in 55 women with RA without overt cardiovascular disease (capital ES, CyrillicVD) treated with rituximab (RTX).The following parameters were recorded before and 24 weeks after RTX therapy (2 infusions of 500 or 1,000 mg RTX intravenously, fortnightly): plasma total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides, DAS 28-ESR, serum C-reactive protein (CRP), RF IgM, AS (SI - stiffness index, RI - reflection index) by digital volume pulse contour analysis (Micro Medical, UK), and common cIMT by high-resolution B-mode carotid ultrasound. Based on the European League Against Rheumatism (EULAR) criteria, patients were divided into two groups: 1) moderate/good response to RTX therapy after 24 weeks (41 patients, 75%), 2) no response to RTX therapy (14 patients, 25%). Effective RTX therapy resulted in 9% increase in TC, 23% increase in HDL-C and 14% decrease in atherogenic index, 57% decrease in SI and 24% decrease in RI. We observed a 9% decrease of cIMTmax at 24 weeks. The improvement of cardiovascular parameters was accompanied by statistically significant decreases of CRP, ESR, RF IgM and DAS 28 in group 1 (P < 0.05). There were not significant changes in lipid profile, AS parameters, and cIMT in group 2. Two infusions of RTX in case of moderate/good EULAR effect of therapy exerted favorable effects on lipid profile, AS and cIMT in women with RA without overt CVD.
Antirheumatic Agents/*therapeutic use
;
Arthritis, Rheumatoid/complications/*drug therapy/physiopathology
;
Biomarkers/blood
;
C-Reactive Protein/analysis
;
Cardiovascular Diseases/complications
;
Carotid Intima-Media Thickness
;
Cholesterol, HDL/blood
;
Cholesterol, LDL/blood
;
Female
;
Humans
;
Lipids/*blood
;
Middle Aged
;
Rituximab/*therapeutic use
;
Treatment Outcome
;
Triglycerides/blood
;
Vascular Stiffness