1.Clinical Observation on Juvenile Rheumatoid Arthritis.
Journal of the Korean Pediatric Society 1986;29(2):34-44
No abstract available.
Arthritis, Juvenile*
2.A Case of Systemic-Onset Juvenile Rheumatoid Arthritis with Multiple Complications.
Jong Deok KIM ; Dong Joo NA ; Jin Han KANG ; Kyong Su LEE ; Ki Yeal SUNG
Journal of the Korean Pediatric Society 1988;31(7):948-952
No abstract available.
Arthritis, Juvenile*
3.Clinical observation on juvenile theumatoid arthritis.
Journal of the Korean Pediatric Society 1991;34(8):1123-1131
No abstract available.
Arthritis*
;
Arthritis, Juvenile
4.Association of Human Leukocyte Antigen-DRB1 with Juvenile Idiopathic Arthritis.
Journal of Rheumatic Diseases 2014;21(5):225-227
No abstract available.
Arthritis, Juvenile*
;
Humans
;
Leukocytes*
5.Clinical significance of rheumatoid factor in juvenile rheumatoid arthritis.
Ki Joong KIM ; Bo Young YUN ; Joong Gon KIM
Journal of the Korean Pediatric Society 1992;35(5):639-645
No abstract available.
Arthritis, Juvenile*
;
Rheumatoid Factor*
6.Newly Proposed Classification for Juvenile Idiopathic Arthritis.
Journal of Rheumatic Diseases 2018;25(2):79-80
No abstract available.
Arthritis, Juvenile*
;
Classification*
8.Development of Crohn's Disease during Etanercept Treatment in Juvenile Idiopathic Arthritis.
Journal of Rheumatic Diseases 2014;21(6):340-342
No abstract available.
Arthritis, Juvenile*
;
Crohn Disease*
;
Etanercept
9.Acute leukemian in patients with juvenile rheumatoid arthritis displaysing multiply osteolytic lesions and compression fracture.
Mi Kyoung LIM ; Dong Hyuk SHEEN ; Seoung Cheol SHIM
Korean Journal of Medicine 2002;63(1):103-104
No abstract available.
Arthritis, Juvenile*
;
Fractures, Compression*
;
Humans
10.Association between autophagy and systemic juvenile idiopathic arthritis and related mechanism: a preliminary study.
Jie ZHAO ; Xue ZHAO ; Zhi-Yan DOU ; Zan-Hua RONG
Chinese Journal of Contemporary Pediatrics 2019;21(10):966-971
OBJECTIVE:
To study the role of autophagy in the development of systemic juvenile idiopathic arthritis (sJIA) by analyzing the expression of microtubule-associated protein 1 light chain 3-II (LC3-II), myeloid differentiation factor 88 (MyD88), and suppressor of T-cell receptor signaling 1 (STS-1) in peripheral blood lymphocytes of children with sJIA.
METHODS:
A total of 26 children with sJIA were enrolled as the sJIA group, and 26 healthy children were enrolled as the control group. Western blot was used to measure the protein expression of LC3-II, STS-1, and MyD88 in peripheral blood lymphocytes. Immunofluorescence assay was used to measure the expression of LC3-II in the cytoplasm of lymphocytes. Pearson correlation analysis was used to assess the correlation between indices.
RESULTS:
Compared with the control group, the sJIA group had significant increases in the expression of LC3-II, STS-1, and MyD88 (P<0.05). In the sJIA group, the expression of LC3-II was positively correlated with that of MyD88 (r=0.478, P<0.05), and the expression of STS-1 was also positively correlated with that of MyD88 (r=0.817, P<0.05).
CONCLUSIONS
There is high expression of LC3-II in peripheral blood lymphocytes of children with sJIA, suggesting that the development of sJIA may be associated with excessive expression of autophagy. STS-1 may induce autophagy by activating some signaling pathways, and MyD88 may participate in autophagy through the Toll-like receptor signaling pathway.
Arthritis, Juvenile
;
Autophagy
;
Child
;
Humans
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