No abstract available.
Arteriosclerosis Obliterans* ; Arteriosclerosis* ; Drug Therapy* ; Humans

No abstract available.
Arteriosclerosis Obliterans* ; Arteriosclerosis* ; Drug Therapy* ; Humans

Angioplasty ; methods ; Arteriosclerosis Obliterans ; surgery ; Humans ; Stents

Arteriosclerosis Obliterans ; surgery ; Humans ; Lower Extremity

Refinements in surgical technique have resulted in significant improvement in the patency rates of infrapopliteal artery revascularizations, but the cumulative patency rate were still low. Possibly the principle cause for the late graft failure was the constricting scar formation around the distal anastomosis following surgical injury. Thus we adopted a nondissection method, using pneumatic tourniquet occlusion technique, to simplify the procedure of distal anastomosis and to lessen the surgical injury. Six patients underwent infrapopliteal artery revascularizations with this method. Three of them were diagnosed with arteriosclerosis obliterans and the others with thromboangiitis obliterans. Tourniquet pressures of 350 mmHg were applied from 32 to 60 minutes. All patients were given systemic anticoagulants. The distal anastomoses were performed to peroneal artery in three cases, posterior tibial artery in two, and anterior tibial artery in one. Hemostasis was adequate in all cases and no alternative occlusive devices were required. There were no complications attributable to the use of the pneumatic tourniquet. Therefore we suggest that tourniquet occlusion technique may simplify the infrapopliteal artery revascularization and minimize surgical injury at the distal anastomosis contributed to the long-term patency of the distal bypass.
Anticoagulants ; Arteries* ; Arteriosclerosis Obliterans ; Cicatrix ; Hemostasis ; Humans ; Intraoperative Complications ; Thromboangiitis Obliterans ; Tibial Arteries ; Tourniquets* ; Transplants

Fusarium species are a group of soil, saprobic and phytopathogic fungi. The pathogen generally affects immunocompromised individuals and infection of immunocompetent people is rarely reported. Fusarium species frequently have been found in immunocompetent people's burned tissue and skin ulcers. We describe a case of cutaneous infection by Fusarium solani in an immunocompetent 67-year-old patient associated with arteriosclerosis obliterans. To the best of our knowledge, this has not been previously reported in the Korean dermatological literature.
Aged ; Arteriosclerosis Obliterans* ; Arteriosclerosis* ; Burns ; Fungi ; Fusarium* ; Humans ; Skin Ulcer ; Soil

BACKGROUND: The administration of low dose heparin and dextran therapy in patients with arterial bypass surgery is thought to prevent thrombosis and graft occlusion. The purpose of this study was to evaluate the effectiveness of low dose heparin and dextran in atherosclerosis patients presenting hypercoagulability. METHODS: Whole blood coagulation was evaluated using thrombelastography and standard coagulation testing before and a day after surgery in nine atherosclerotic patients and nine control patients. Heparin 5000 U and dextran 500 ml were administrated in atherosclerotic patients during their operations. RESULTS: Atherosclerotic patients showed higher maximal amplitude compared to the control patients during preoperative thrombelastography. After surgery atherosclerotic patients revealed no significant change, but the control group became more hypercoagulable in status compared to the preoperative period. CONCLUSIONS: Intravenous heparin and dextran prevented postoperative change to a more hypercoagulable state than the preoperative status in atherosclerotic patients undergoing arterial bypass surgery.
Anticoagulants ; Arteriosclerosis Obliterans* ; Arteriosclerosis* ; Atherosclerosis ; Blood Coagulation ; Dextrans* ; Heparin* ; Humans ; Preoperative Period ; Thrombelastography ; Thrombophilia ; Thrombosis ; Transplants

BACKGROUND: A non-randomized, uncontrolled study was undertaken with a retrospective medical record review to evaluate the effect of pain relief of chemical lumbar sympathectomy in patients with peripheral vascular occlusive disease. This was conducted to assess whether the long term outcome of ischemic limbs could be changed and to identify predictable medical factors of patients who would be helped by this procedure. METHODS: A total of 47 patients with Buerger's disease (n = 20) and arteriosclerosis obliterans (n = 17) referred by vascular surgery for the management of ischemic pain were enrolled. All other conservative and surgical management efforts had already failed and were not indicated. The following were evaluated before and after the neurolytic lumbar sympathetic blocks: the stages of disease by Fontaine classification, main sites and numbers of occlusion, pain scores before and after the procedure, physical findings, amputation sites, and medications as well as amounts given and other risk factors. RESULTS: Buerger's disease tends to progress rapidly and aggressively. It is more painful than arteriosclerosis obliterans and is peripherally involved, with higher incidences of complications. Chemical sympathectomy has significant pain relief effects in both groups. Differences in long term outcome measured by amputation could not be found in both groups. No significant risk factors could be identified. No side effects were reported in both groups. CONCLUSIONS: Chemical lumbar sympathectomy has a good analgesic effect for pain in walking. This, however showed no long-term limb-saving effect.
Amputation ; Arterial Occlusive Diseases* ; Arteriosclerosis Obliterans* ; Arteriosclerosis* ; Classification ; Extremities ; Humans ; Incidence ; Medical Records ; Retrospective Studies ; Risk Factors ; Sympathectomy ; Sympathectomy, Chemical ; Thromboangiitis Obliterans* ; Walking

Pain is a sensory experience that is subjective and individual. It frequently exceeds its protective function and becomes destructive. We have met one case of causalgia, three cases of Buergers disease, and one case of arteriosclerosis obliterance. They sufferred from persistent pain and exkausted with the marked distrophy of affected limbs. Management of these patient involving lower limbs is a continuing challenge. Many other therapheutic procedures could be tried for these patients, but we tried chemical lumbar sympathectomy for these cases. With respect to the lower extremity, four patients had neurolysis of the 1st, 2nd and 3rd ipsilateral or 2nd and 3rd bilateral lumbar ganglia using 3 to 5 ml pure alcohol for each space under the image intensifier. Immediately after these procedure, rest pain has relieved dramatically in most cases and marked skin temperature rising. This implied increased peripheral blood flow of sympathectomised portion and the relief of rest pain is probably explained by destrcution of the afferent pain fibres running with the sympathetic trunk.
Arteriosclerosis ; Causalgia ; Extremities ; Ganglia ; Humans ; Lower Extremity ; Running ; Skin Temperature ; Sympathectomy* ; Thromboangiitis Obliterans

OBJECTIVETo identify distinct proteins involved in human atherosclerosis obliterans (ASO) by a differential proteomic approach.

METHODSEight atherosclerotic femoral arteries with a mean age of 68.6 years (6 male and 2 female) and 5 normal femoral arteries with a mean age of 44.2 years (3 male and 2 female) were obtained from high amputation patients. Then the first 2-dimensional maps of the proteome of human femoral arteries was plotted to compare ASO and control specimens. Proteomic profiling was to differentiate and identify histological proteins that were associated with ASO. The differentially expressed proteins were sequenced by matrix assisted laser desorption/ionization mass spectrometry (MALDI-TOF-MS). The result was verified by immunohistochemistry (IHC) and Western blot.

RESULTSASO was associated with distinct patterns of protein expression in the femoral arteries. A total of 25 distinct spots corresponding to 13 different proteins were identified by MALDI-TOF-MS using the NCBI and IPI databases. These proteins were mainly involved in the pathogenetic mechanisms such as inflammation, oxidative stress, proliferation and transformation of SMCs. The low level of heat shock protein 27 (HSP27) in ASO was verified by IHC and western-blot in accord with the result of MS.

CONCLUSIONProteomic analysis can be used to investigate differentially expressed proteins, which may provide new insights into ASO pathogenesis, such as HSP27.

Adult ; Aged ; Arteriosclerosis Obliterans ; metabolism ; pathology ; Female ; Humans ; Male ; Middle Aged ; Proteome ; metabolism