1.Weathering the storm: COVID-19 infection in patients with hematological malignancies.
Lin-Qin WANG ; Elaine TAN SU YIN ; Guo-Qing WEI ; Yong-Xian HU ; Arnon NAGLER ; He HUANG
Journal of Zhejiang University. Science. B 2020;21(12):921-939
The coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Within a matter of months, this highly contagious novel virus has led to a global outbreak and is still spreading rapidly across continents. In patients with COVID-19, underlying chronic diseases and comorbidities are associated with dismal treatment outcomes. Owing to their immunosuppressive status, patients with hematological malignancies (HMs) are at an increased risk of infection and have a worse prognosis than patients without HMs. Accordingly, intensive attention should be paid to this cohort. In this review, we summarize and analyze specific clinical manifestations for patients with coexisting COVID-19 and HMs. Furthermore, we briefly describe customized management strategies and interventions for this susceptible cohort. This review is intended to guide clinical practice.
COVID-19/prevention & control*
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Diagnosis, Differential
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Disease Management
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Hematologic Neoplasms/virology*
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Hospitalization
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Humans
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Immunocompromised Host
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Risk Factors