1.Results of cardiac electrical stability of Mongolian population of by the method of dispersion visual image electrocardiography
Mongolian Medical Sciences 2018;185(3):59-64
Introduction:
Cardiovascular diseases remains the leading cause of morbidity and mortality in most developed and developing countries. The 34.3% of mortality are due to cardiovascular diseases are in Mongolia. The lifetime risk of cardiovascular disease can be predicted by cardiac electrical instability and arrhythmia findings in ECG. The lack of nationwide data and large multicenter studies in our country do not allow us to estimate the true extend of the problem and we want doing the analysis of the cardiac electrical stability and myocardial index.
Goal:
Evaluate prevalence of cardiac electrical stability and myocardial index of Mongolian people
Material end Methods:
The subjects were recruited from The “Brilliant Hospise” Hospital of Ulaanbaatar, between April 2017 to May 2018. A total of 1000 consecutive patients, aged between 20-70 years were selected. Research was conducted by descriptive research design, anamnesis, anthropometry measurement, laboratory research and was analyzed dispersion visual image ECG. Statistics data was analyzed by SPSS 27 software.
Results:
1000 surveyed aged 20-70 questionnaires, anthropometry measurements, fasting venous blood cholesterol and glucose determined and ECG dispersion visual image sensitive to power quality integrated change and electrical instability of very low frequency change, stimulate the formation and electrical transmission loss, heart disease 23,7% of 610 people surveyed in a relatively healthy and electrical stability of the heart muscle are unchanged, tachycadia, power generation and transmission losses, thickening of the heart muscle, axial deviation, other heart disease due had myocardial electrical instability and changed HRV.
Conclusion
In this study, we demonstrated that prevalence of myocardial electrical instability and myocardial index of relatively healthy people Mongolia. 23,7% of all healthy people changed myocardial electrical instability and HRV. This method that sensitivity of dispersion functions in differentiating norm, premorbid stage and pathologies in many cases in higher than sensitivity of the usual ECG analysis.
2.The risk assessment of atrial fibrillation
Ochirchimeg G ; Ariuntsetseg N
Mongolian Medical Sciences 2018;185(3):54-58
Introduction:
Although we have known for almost last few years that Atrial fibrillation has been increasing by patients in Mongolia. Atrial fibrillation, the most common sustained chronic arrhythmia, with atrial rates of 200-500 beats per minute in patients. Most patients atrial fibrillation have structural heart disease such us mitral stenosis or regurgitation, acute myocardial infarction, Wolff-Parkinson-White syndrome, thyrotoxicosis, recent cardiothoracic surgery, cardiomyopathy, myocarditis or pulmonary disease. Atrial Fibrillation increases the risk of stroke, thromboemboli and mortality of adults with structural heart disease [4]. The symptoms most frequently reported by patients with atrial fibrillation is a rapid, irregullar heartbeat, chest pain, shortness of breath, lightheadedness and dizziness.
Goal:
For that reason we decided to research patients with atrial fibrillation who are treated by the inpatient cardiology department of General hospital of defense and Law Enforcement between 2010-2014 years.
Conclusion
1. The hospitalized patients are observed only 6 cases of atrial fibrillation in 2010 years, even though the prevalence of atrial fibrillation has been increasing 75 cases in 2014 years, as a result it developed 30% during 4 years in hospitalized patients
2. CHA2DS2-VАSc score was high risk of stroke /62.5% of them /most patients with both paroxysmal and chronic atrial fibrillation should be anticoagulated to reduce the occurrence of thromboemboli
3. HAS-BLЕD score has became highest rick of bleeding /32.7% of all patients. For the reason we should be select correctly drugs for patients an anticoagulation treatment and they are controled INR every month
3.Early diagnosis of nephropathy in patients with hypertension
Naran-Ulzii S ; Ariunaa T ; Baigalmaa E ; Ariuntsetseg N ; Enkhtuya J
Mongolian Medical Sciences 2011;172(2):45-49
Background: High blood pressure is both a cause and a complication of chronic kidney disease. As complication, high blood pressure may develop early during course of chronic kidney disease and is associated with adverse outcomes, in particular faster loss of kidney function and development of cardiovascular disease. The purpose of this study is early detection of chronic kidney disease in patients with hypertension by defining the prevalence of microalbuminuria.Methods: The study population consisted of 169 subjects with a hypertension. Individuals were considered to have hypertension if the blood pressure measured greater than 140/90 mmHg or if they were taking blood pressure lowering medications. Microalbuminuria was defined as 20 mg/l or greater. Results: We are presenting data on 169 subjects :male 38 (22.5%) female 131 (77.5%), average age 51.6±0.89 At screening, 14.8% of all participants were smokers, 62.1 % engaged in low levels of physical activity, 72.8% - were having tea with salt (table1). Microalbuminuria and renal failure, as GFR<60 ml/ min/1.73 m2, were documented in 34.3% and 16.6% of subjects, respectively. There is positive correlation between MAU and increasing-range of blood pressure (table2). Correlation was found between albuminuria and GFR(r= -0.2 p<0.01) and serum creatinine(r=0.31 p<0.01) the regression result has shown that GFR is associated with MAU and serum creatinine (table 3).Conclusions:1. In 34.3% of patient with hypertension was found nephropathies with MAU2. Microalbuminuria is increased with decline of GFR and raise of systolic blood pressure. GFR decline is with the raise of age and serum. It is important to implement in clinical practice screening of MAU hypertensive patients.3. In 2/3 of all screened subjects was found 1 and more risk factors for CVD.
4.Technological study for obtaining an appropriate extract from Stellera Chamaejasme L. and Oxytropis Pseudoglandulosa
Maitsetseg N ; Ariuntsetseg A ; Altantuya Ts ; Ulambayar L ; Altansukh Ts ; Tserendolgor B
Mongolian Pharmacy and Pharmacology 2023;22(1):22-27
Background:
Infections in respiratory systems have spread throughout the world without any restrictions including living places, public issues, and lifestyle. Three main causes of illnesses for the population of cities and rural areas were gastrointestinal diseases, respiratory diseases, and cardiovascular diseases. After investigated some medicinal herbs including Stelleria Chamaejasme L. and Oxytropis Pseudoglandulosa, it has been reported that they had antiinflammatory, analgesic, and wound healing effects. Lozenge formulation has some advantages for treatment application, such as easily absorbed, good bioavailability and ability of diminishing stomach irritation. In this study, we aimed to obtain a suitable extract from Stelleria Chamaejasme L. and Oxytropis Pseudoglandulosa for further lozenge formulation.
Purpose:
To obtain a suitable extract from Stelleria Chamaejasme L. and Oxytropis Pseudoglandulosa, and to conduct qualitative and quantitative studies for some biologically active substances
Materials and methods:
In this study, an aerial part of Stelleria Chamaejasme L. and Oxytropis Pseudoglandulosa were used, and the study was conducted in MUPS. For obtaining a suitable extract, the raw materials were extracted by remaceration, repercolation and circulation methods in 20% and 70% of ethanol and distilled water. The flavonoids and polyphenolic compounds in the extracts were determined by thin layer chromatography. Quantitative analysis for total flavonoids was performed by spectrophotometer.
Results:
According to the result, a yellow spot-on chromatogram was detected in extracted raw materials (Stelleria Chamaejasme L. and Oxytropis Pseudoglandulosa), indicating that flavonoid contained in the extracted solution.
The result was compared to standards of rutin (Rf=0.2) and quercetin (Rf= 0.94). Also, a black, blue spot-on chromatogram was detected in extracted raw materials (Stelleria Chamaejasme L. and Oxytropis Pseudoglandulosa), indicating that polyphenols contained in the extracted solution. The spots were compared to gallic acid as a standard substance. In the quantitative assay of total flavonoids in raw materials, black-green precipitation was revealed after procedure. From this result, remaceration and circulation techniques were suitable to extract the raw materials. Flavonoid content was 3.35±0.04% after using remaceration technique, which indicated that it was more suitable to extract the raw materials.
Conclusions
These results showed that the appropriate extracting solution for Stelleria Chamaejasme L. and Oxytropis Pseudoglandulosa was 70% of ethanol. In this case, 3.35±0.04% of flavonoid was extracted by remaceration technique.