1.Promotion of excisional wound repair by a menstrual blood-derived stem cell-seeded decellularized human amniotic membrane.
Saeed FARZAMFAR ; Majid SALEHI ; Arian EHTERAMI ; Mahdi NASERI-NOSAR ; Ahmad VAEZ ; Amir Hassan ZARNANI ; Hamed SAHRAPEYMA ; Mohammad Reza SHOKRI ; Mehdi ALEAHMAD
Biomedical Engineering Letters 2018;8(4):393-398
This is the first study demonstrating the efficacy of menstrual blood-derived stem cell (MenSC) transplantation via decellularized human amniotic membrane (DAM), for the promotion of skin excisional wound repair. The DAM was seeded with MenSCs at the density of 3 × 10⁴ cells/cm² and implanted onto a rat's 1.50 × 1.50 cm² full-thickness excisional wound defect. The results of wound closure and histopathological examinations demonstrated that the MenSC-seeded DAM could significantly improve the wound healing compared with DAM-treatment. All in all, our data indicated that the MenSCs can be a potential source for cell-based therapies to regenerate skin injuries.
Amnion*
;
Humans*
;
Skin
;
Stem Cells
;
Wound Healing
;
Wounds and Injuries*
Result Analysis
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