This is a case report of a developmentally healthy 14-month-old female with partial thickness scald burns at multiple sites (the face, trunk, and bilateral upper extremities) that covered 14% of her total body surface area. Novel procedural pain therapy using intravenous lidocaine and oral ketamine was administered to perform daily wound care with minimal discomfort. Following this daily analgesic protocol there was sufficient analgesia and sedation with no adverse side effects. Currently, there are no studies where this analgesic combination was used during burn wound care and dressing changes in pediatric cases. The success of this protocol in a pediatric case highlights the safety and efficacy of oral ketamine when used in conjunction with intravenous lidocaine which potentially allows for a lower dose per procedure and a reduced risk of adverse effects.