No abstract available.
Aquaporins* ; Kidney*

No abstract available.
Aquaporins* ; Kidney* ; Physiology*

No abstract available.
Aquaporins ; Otitis Media ; Otitis

No abstract available.
Acute Kidney Injury* ; Aquaporins* ; Nitric Oxide*

Aquaporins ; metabolism ; Humans ; Kidney Diseases ; metabolism

No abstract available.
Animal ; Aquaporins/metabolism* ; Exocrine Glands/metabolism* ; Water/metabolism*

To investigate the role of AQP9 in brain edema, the expression of AQP9 in an infectious rat brain edema model induced by the injection of lipopolysaccharide (LPS) was examined. Immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR) analysis demonstrated that the expressions of AQP9 mRNA and protein at all observed intervals were significantly increased in LPS-treated animals in comparison with the control animals. Time-course analysis showed that the first signs of blood-brain barrier disruption and the increase of brain water content in LPS-treated animals were evident 6 h after LPS injection, with maximum value appearing at 12 h, which coincided with the expression profiles of AQP9 mRNA and protein in LPS-treated animals. The further correlation analysis revealed strong positive correlations among the brain water content, the disruption of the blood-brain barrier and the enhanced expressions of AQP9 mRNA and protein in LPS-treated animals. These results suggested that the regulation of AQP9 expression may play important roles in water movement and in brain metabolic homeostasis associated with the pathophysiology of brain edema induced by LPS injection.
Aquaporins/genetics ; Aquaporins/*metabolism ; Blood-Brain Barrier/metabolism ; Brain/drug effects ; Brain/physiology ; Brain Edema/chemically induced ; Brain Edema/*metabolism ; Lipopolysaccharides ; Rats, Sprague-Dawley ; Water/physiology

Chronic renal failure, which has an increased single nephron glomerular filtration rate in remnant kidney, is known to cause characteristic structural alterations in renal tubule epithelia in association with impaired urinary concentration and deranged urinary sodium excretion. This mini-review will deal with the changes in the renal expression of aquaporins (AQPs) and sodium transporters for elucidating the underlying cellular and molecular mechanisms for the urinary abnormalities of decreased urinary concentration and increased urinary sodium excretion.
Aquaporins* ; Glomerular Filtration Rate ; Kidney ; Kidney Failure, Chronic* ; Membrane Transport Proteins ; Nephrons ; Renal Insufficiency ; Sodium*

Hypertension is closely related to salt and water retention. The kidney plays an important role in the blood pressure regulation primarily to modulating tubular sodium and water reabsorption. The regulation of the salt and water balance depends upon an array of solute and water channels in the renal tubules. An altered regulation of sodium and water channels in the kidney may be related to various pathological conditions associated with altered salt and water retention. This review will discuss renal handling of sodium and water, with particular emphasis on aquaporins and renal sodium transporters and channels.
Aquaporins ; Blood Pressure ; Handling (Psychology) ; Hypertension ; Kidney ; Membrane Transport Proteins ; Retention (Psychology) ; Sodium ; Water

In recent years, the discovery and studies on aquaporin have made us have a more in-depth understanding about the physiological and pathological processes of water metabolism. Over years, however, there has been no quantitative study on the target sites of diuretic traditional Chinese medicines at the molecular level. In that case, aquaporin was found to been a new target molecule to explain the efficacy exertion of diuretic traditional Chinese medicines. By studying aquaporin, researchers can understand the implicit meaning of the diuretic effect of traditional Chinese medicines and conduct quantitative studies on the diuretic effect. So far, many scholars have conducted a series of studies in the traditional Chinese medicine field by using the findings on aquaporin and made certain advances. This article provides a summary about the efficacy exertion of diuretic traditional Chinese medicines through target molecule aquaporin.
Animals ; Aquaporins ; genetics ; metabolism ; Diuretics ; pharmacology ; Drugs, Chinese Herbal ; pharmacology ; Humans ; Medicine, Chinese Traditional ; Water ; metabolism