1.A Case of Linitis Plastica Involving the Entire Colon, Ileum, and Appendix.
Joon Yong PARK ; Dong Soo HAN ; Hang Lak LEE ; Jin Bae KIM ; Joo Hyun SOHN ; Ho Soon CHOI ; Young Soo NAM ; Yong Wook PARK ; Joon Soo HAHM
The Korean Journal of Gastroenterology 2003;42(3):237-241
Linitis plastica of the colon is an uncommon presentation of primary colorectal cancer. This entity of colorectal cancer is characterized by a diffuse infiltrating tumor with desmoplastic reaction and poor prognosis. Although widespread infiltration is the main feature of linitis plastica, the tumor extending to more than 2 segments of the colon is uncommon. We report a case of primary linitis plastica involving the entire colon, ileum and appendix. The clinical characteristics are discussed with a review of literatures.
Adult
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Appendiceal Neoplasms/*pathology
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Colonic Neoplasms/*pathology
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Humans
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Ileal Neoplasms/*pathology
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Linitis Plastica/*pathology
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Male
2.Pseudomyxoma peritonei: report of 11 cases with a literature review.
Ying DONG ; Ting LI ; Wanzhong ZOU ; Ying LIANG
Chinese Journal of Pathology 2002;31(6):522-525
OBJECTIVEThe clinicopathologic and immunohistochemical features of 11 pseudomyxoma peritonei (PMP) cases were studied to determine pathologic diagnosis, site of origin and prognosis.
METHODSClinical files of 11 cases of PMP were reviewed with follow up. The changes in mucinous tumors of peritoneum and primary tumors under microscope and immunostaining were reviewed.
RESULTSEleven cases (8 women, 3 men) are reported. The patients age ranged from 36 to 76 (average 56). One died 2 years after operation, and one case was lost. The remaining 8 cases were alive 1 to 60 months postoperatively. Of the 11 cases, 8 cases had appendiceal mucinous neoplasm of the 11 cases, and 5 women had synchronous ovarian mucinous tumors; colon mucinous adenocarcinoma was present in one case with synchronous ovarian mucinous tumor; simple ovarian mucinous tumors were present in two cases. Immunostainings were consistent on mucinous tumors of appendix, ovary and peritoneum in the same case.
CONCLUSIONSTo diagnose the PMP, the type of tumor should be considered whether it is benign, low malignant or malignant. The appendix neoplasm is closely related to PMP. The prognosis depends greatly on the growth speed of the mucinous neoplasm.
Adult ; Aged ; Appendiceal Neoplasms ; diagnosis ; pathology ; Diagnosis, Differential ; Female ; Humans ; Male ; Middle Aged ; Ovarian Neoplasms ; diagnosis ; pathology ; Peritoneal Neoplasms ; diagnosis ; pathology ; Prognosis ; Pseudomyxoma Peritonei ; diagnosis ; pathology
3.Goblet cell carcinoid of appendix: report of two cases.
Xue-dong ZHANG ; Chun-nian HE ; Jin-ping ZHAI ; Huan-fen ZHAO ; Chen CHEN ; Wei-dong SHI
Chinese Journal of Pathology 2006;35(2):126-127
Adenocarcinoma, Mucinous
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pathology
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Aged
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Appendectomy
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methods
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Appendiceal Neoplasms
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pathology
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surgery
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Appendicitis
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pathology
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Appendix
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pathology
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Carcinoid Tumor
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pathology
;
surgery
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Diagnosis, Differential
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Female
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Follow-Up Studies
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Humans
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Male
4.Repeatedly Recurrent Colon Cancer Involving the Appendiceal Orifice after Endoscopic Piecemeal Mucosal Resection: A Case Report.
Masau SEKIGUCHI ; Takahisa MATSUDA ; Shigeki SEKINE ; Taku SAKAMOTO ; Takeshi NAKAJIMA ; Ryoji KUSHIMA ; Takayuki AKASU ; Yutaka SAITO
The Korean Journal of Gastroenterology 2013;61(5):286-289
Local recurrence after endoscopic piecemeal mucosal resection (EPMR) for colorectal tumors is a crucial issue. However, such recurrence is usually detected within one year and cured with additional endoscopic treatment, which makes EPMR acceptable. Herein, we report a rare case of repeatedly recurrent colon cancer involving the appendiceal orifice after EPMR, which was not cured with additional endoscopic treatments. A 67-year-old man was referred to us for endoscopic treatment of a 25 mm cecal tumor spreading to the appendiceal orifice in May 2002. The tumor was resected with EPMR, showing well differentiated intramucosal adenocarcinoma with a positive lateral cut margin of tubular adenoma. Endoscopic surveillance was conducted and the first local recurrence was detected in August 2006. Although we resected it endoscopically, the second local recurrence was found in September 2007 and we removed it with endoscopic resection again. However, the third local recurrence was detected in March 2008. Although endoscopic resection was performed also for the third recurrence, curative resection was not achieved. In February 2009, laparoscopic assisted colectomy was performed and histopathological examination showed well differentiated adenocarcinoma with deep submucosal invasion. This case is important in considering indication for endoscopic resection in colorectal tumors involving the appendiceal orifice.
Adenocarcinoma/*diagnosis/pathology/surgery
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Aged
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Appendiceal Neoplasms/complications
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Colectomy
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Colonic Neoplasms/*diagnosis/pathology/surgery
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Colonoscopy
;
Humans
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Intestinal Mucosa/pathology
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Male
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Neoplasm Recurrence, Local
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Recurrence
5.Appendiceal Neuroendocrine Tumor with Lymph Node Metastasis in a Teenager.
Keun Young KIM ; Won Cheol PARK
The Korean Journal of Gastroenterology 2015;65(2):127-131
Neuroendocrine tumor (NET) is a cancer-like tumor that occurs mostly in the gastrointestinal system. Within the gastrointestinal tract, NET most commonly occurs in the rectum whereas appendix is very rarely involved. In most cases of appendiceal NET, it is found at a relatively early stage compared to other NETs because appendiceal NET frequently presents with acute appendicitis because appendiceal NET frequently presents with acute appendicitis even when the size is smaller than 1 cm. Therefore, it is very rare for lymph node metastasis to occur in a young adult. Herein, we report a rare case of grade 1 appendiceal NET with lymph node metastasis which developed in a teenage male.
Adolescent
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Appendiceal Neoplasms/*diagnosis/pathology/surgery
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Carcinoid Tumor/diagnosis/pathology
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Colectomy
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Colonoscopy
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Humans
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Lymphatic Metastasis
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Male
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Neuroendocrine Tumors/*diagnosis/pathology
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Tomography, X-Ray Computed
6.Analysis on pathology features and prognosis of appendiceal mucinous neoplasm.
Mei ZHANG ; Fengjuan GAO ; Fanqing MENG ; Yifen ZHANG ; Gang CHEN ; Ping ZENG ; Ming CHEN ; Qiang ZHOU ; Xiangshan FAN
Chinese Journal of Gastrointestinal Surgery 2014;17(1):65-70
OBJECTIVETo explore the pathological features and prognosis of appendiceal mucinous neoplasms (AMN) based on WHO classification 2010.
METHODSSeventy consecutive cases of AMN were classified into 5 groups according to WHO classification of digestive system tumors in 2010 including mucinous adenomas/cystadenoma (MA), low grade appendiceal mucinous neoplasms (LAMN), low grade pseudomyxoma peritoneum originated from appendix (PMP-L), invasive mucinous adenocarcinomas (MAC) and high grade pseudomyxoma peritoneum originated from appendix (PMP-H). Clinicopathological features, classification, treatment and prognosis of AMN were investigated retrospectively.
RESULTSThere were 11 cases of MA with neoplastic epithelium and mucin being defined in lumen and mucosa but without invasive lesions, and no relapse or death was found. In 41 LAMN cases, mucin was found in submucosa, muscularis proparis, or serosa of appendix, no or only scant mucinous epithelium with low grade dysplasia presented in mucinous pools in most cases (39/41). Among 41 LAMN cases, 3 developed relapse or PMP-L, and no death was observed. In 7 PMP-L cases, low grade dysplastic mucinous epithelium in mucinous pools could be found easily in 3 cases and was very scanty in 4 cases, with 1 relapse and 1 death. Eleven invasive carcinomas were found, including 7 MAC cases and 4 PMP-H cases, with local high grade dysplastic epithelium at least. In these invasive lesions, 4 cases recurred and 3 case died (including 2 recurred cases above). MA and LAMN were both non-invasive neoplasms histologically, however, PMP-L, MAC and PMP-H were regarded as adenocarcinomas according to their biological behavior.
CONCLUSIONAMN displays a relatively homogeneous group of neoplasms that pursues a predictable clinical course based on their nature, so it is necessary to diagnose and administrative accurately with consistently standards for these neoplastic entities.
Adenocarcinoma, Mucinous ; pathology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Appendiceal Neoplasms ; classification ; pathology ; Child ; Female ; Humans ; Male ; Middle Aged ; Myxoma ; pathology ; Prognosis ; Young Adult
7.Primary malignant tumor of the appendix: clinicopathological analysis of 22 cases.
Bin HUANG ; Mei-juan DI ; Hong-sheng LIU ; Ling-ling QIU ; Li-jun SUN ; Jin-ping XU
Journal of Zhejiang University. Medical sciences 2009;38(2):194-198
OBJECTIVETo investigate the clinicopathological and immunohistochemical features of primary malignant tumor of the appendix.
METHODSThe clinical data were reviewed; and histopathological and immunohistochemical features were analyzed in 22 cases with primary malignant tumor of the appendix.
RESULTIn 22 cases of primary malignant tumor of the appendix, 19 cases were carcinoid and 3 were adenocarcinoma. Immunohistochemistry showed that the carcinoid was positively reacted to the neuroendocrine markers, and the adenocarcinoma was negatively reacted to the neuroendocrine markers.
CONCLUSIONImmunohistochemistry is useful in diagnosis of primary malignant tumor of the appendix, a rare type of cancer.
Adenocarcinoma ; diagnosis ; pathology ; surgery ; Adolescent ; Adult ; Aged ; Appendiceal Neoplasms ; diagnosis ; pathology ; surgery ; Carcinoid Tumor ; diagnosis ; pathology ; surgery ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Young Adult
8.Goblet cell adenocarcinoma in the digestive system: a clinicopathological analysis of 22 cases.
Zhong CAO ; Shu Kun ZHANG ; Hong Bing CEN ; Jian Guo WEI ; Ling Zhi QIN ; Qilin AO
Chinese Journal of Pathology 2022;51(10):1013-1018
Objective: To investigate the clinical features, morphological characteristics, immunophenotype, and differential diagnosis of goblet cell adenocarcinoma (GCA) in the digestive system. Methods: The clinicopathological data, morphological characteristics, immunophenotypes of 22 cases of GCA in the digestive system diagnosed from January 2010 to January 2021 were collected. Meanwhile, 25 cases of neuroendocrine neoplasm (NEN) and 24 cases of adenocarcinoma were used as controls. Relevant literature was also reviewed. Results: There were 16 males and 6 females, aged from 36 to 79 years with an average of 56 years. The anatomical sites of the 22 GCA were mostly appendix (17 cases) and occasionally extra-appendix (5 cases), including 3 cases in stomach, 1 case in duodenum and 1 case in anal. All 17 cases of appendiceal GCA were pure GCA. Among the 5 cases of extra-appendiceal GCA, One case of gastric GCA was pure, two cases of gastric GCA with NEN or adenocarcinoma, duodenal GCA with NEN and adenocarcinoma, anal GCA with NEN.Low-grade GCAs were composed of goblet, Paneth and neuroendocrine cells, which were arranged in intestinal crypt tubular or cluster structures and distributed in the wall of digestive system. The tubular and cluster structures lacked adhesion. Goblet cells were columnar, located in the base, with clear cytoplasm, small nuclei, inconspicuous atypia, and uncommon mitoses. Extracellular mucus and signet-ring cells with nuclear variations could be seen in some cases. Nerve fiber bundle invasion and tumor thrombus in vessels were often present. High-grade GCAs lacked tubular and cluster structures, and their histological structures were more complex. Tumor cells expressed mixed neuroendocrine and glandular epithelial markers. Similar to the expression patterns of synaptophysin and chromogranin A, CD200 and INSM1 were also dot-like or patch-positive in GCA. Conclusions: GCA is an infrequent tumor of the digestive system and shows the bi-directional differentiation characteristics of neuroendocrine and glandular epithelium. Accurate diagnosis and staging are related to its prognosis.
Adenocarcinoma/pathology*
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Appendiceal Neoplasms/surgery*
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Carcinoid Tumor/surgery*
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Chromogranin A
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Female
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Goblet Cells/pathology*
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Humans
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Male
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Neuroendocrine Tumors/pathology*
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Repressor Proteins
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Synaptophysin
10.Appendiceal Immunoglobulin G4-Related Disease Mimicking Appendiceal Tumor or Appendicitis: A Case Report.
Hyun Soo KIM ; Won Kyung KANG ; Dong Jin CHUNG
Korean Journal of Radiology 2016;17(1):56-58
Immunoglobulin G4 (IgG4)-related disease is an autoimmune disease that forms tumorous lesions. Several cases involving various organs are reported, however, IgG4-related disease involving appendix has not been reported yet. In this report, we presented a case of IgG4-related disease of appendix, which raised a suspicion of appendiceal tumor or usual appendicitis and, therefore, led to unnecessary surgical resection. IgG4-related disease should be considered in the differential diagnosis for a mass-like swelling of the appendix, in order to avoid unnecessary surgery.
Appendiceal Neoplasms/*diagnosis
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Appendicitis/*diagnosis
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Appendix/immunology/*pathology
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Autoimmune Diseases/*diagnosis/immunology
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Diagnosis, Differential
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Humans
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Immunoglobulin G/*immunology
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Male
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Middle Aged
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Neoplasms