Objective To compare efficacy and safety of clavicular hook plate and Kirschner wire in treat-ment of clavicular fracture.Methods 72 patients with clavicle closed fracture were chosen as the research objects, they were randomly divided into the observation group and control group according to randomly number table,the con-trol group were treated with Kirschner wire intramedullary fixation,the observation group were treated with clavicular plate S plate internal fixation.The effect and the complication rate of two groups were compared.Results In the observation group,the fracture healing time was (13.51 ±1.06) weeks,the control group was (18.35 ±2.14) weeks, there were significant difference between the two groups in fracture healing time( t=5.54,P<0.05);postoperative follow-up in the observation group,the excellent and good rate was 94.44%,69.45%in the control group,the excel-lent and good rate of two groups had significant difference(χ2 =4.16,P<0.05);the observation group the postopera-tive complication rate was 47.22%,the control group was 77.78%,complications had significantly different(χ2 =5.21,P<0.05).Conclusion Compared with Kirschner wire,,S plate internal fixation for treatment of clavicle closed comminuted fracture has effective in treatment and high safety,which is worthy of further clinical application.