1.Endoscopic Postoperative Recurrence Rates in Crohn's Disease in Korea: The Beginning of a New Approach?.
Paulo Gustavo KOTZE ; Rogerio SAAD-HOSSNE ; Antonino SPINELLI
Intestinal Research 2014;12(3):258-259
No abstract available.
Crohn Disease*
;
Korea
;
Recurrence*
2.Conventional Versus Biological Therapy for Prevention of Postoperative Endoscopic Recurrence in Patients With Crohn's Disease: an International, Multicenter, and Observational Study.
Paulo Gustavo KOTZE ; Antonino SPINELLI ; Rodolff Nunes DA SILVA ; Ivan Folchini DE BARCELOS ; Fabio Vieira TEIXEIRA ; Rogerio SAAD-HOSSNE ; Idblan Carvalho DE ALBUQUERQUE ; Marcia OLANDOSKI ; Lorete Maria DA SILVA KOTZE ; Yasuo SUZUKI ; Akihiro YAMADA ; Ken TAKEUCHI ; Matteo SACCHI ; Takayuki YAMAMOTO
Intestinal Research 2015;13(3):259-265
BACKGROUND/AIMS: Postoperative endoscopic recurrence (PER) occurs in nearly 80% of patients 1 year after ileocecal resection in patients with Crohn's disease (CD). Biological agents were more effective in reducing the rates of PER in comparison with conventional therapy, in prospective trials. The aim of this study was to compare the PER rates of biological versus conventional therapy after ileocecal resections in patients with CD in real-world practice. METHODS: The MULTIPER (Multicenter International Postoperative Endoscopic Recurrence) database is a retrospective analysis of PER rates in CD patients after ileocecal resection, from 7 referral centers in 3 different countries. All consecutive patients who underwent ileocecal resections between 2008 and 2012 and in whom colonoscopies had been performed up to 12 months after surgery, were included. Recurrence was defined as Rutgeerts' score > or =i2. The patients were allocated to either biological or conventional therapy after surgery, and PER rates were compared between the groups. RESULTS: Initially, 231 patients were evaluated, and 63 were excluded. Of the 168 patients in the database, 96 received anti-tumor necrosis factor agents and 72 were treated with conventional therapy after resection. The groups were comparable regarding age, gender, and perianal disease. There was longer disease duration, more previous resections, and more open surgical procedures in patients on biologicals postoperatively. PER was identified in 25/96 (26%) patients on biological therapy and in 24/72 (33.3%) patients on conventional therapy (P=0.310). CONCLUSIONS: In this retrospective observational analysis from an international database, no difference was observed between biological and conventional therapy in preventing PER after ileocecal resections in CD patients.
Biological Factors
;
Biological Therapy*
;
Colonoscopy
;
Crohn Disease*
;
Humans
;
Necrosis
;
Observational Study*
;
Recurrence*
;
Referral and Consultation
;
Retrospective Studies
;
Tumor Necrosis Factor-alpha
3.Granulomatous Mastitis during Chronic Antidepressant Therapy: Is It Possible a Conservative Therapeutic Approach?.
Maurizio BELLAVIA ; Giuseppe DAMIANO ; Vincenzo Davide PALUMBO ; Gabriele SPINELLI ; Giovanni TOMASELLO ; Antonio MARRAZZO ; Silvia FICARELLA ; Antonio BRUNO ; Antonino SAMMARTANO ; Tiziana FIORENTINI ; Antonio SCIO ; Carolina MAIONE ; Attilio Ignazio LO MONTE
Journal of Breast Cancer 2012;15(3):371-372
Granulomatous mastitis is a rare benign inflammatory disease of the breast with multiple etiologies such as tuberculosis, sarcoidosis, foreign body reaction, and mycotic and parasitic infections. In contrast, idiopathic granulomatous mastitis (IGM) is characterized by the presence of chronic granulomatous lobulitis in the absence of an obvious etiology. Clinically and radiologically it may mimic breast carcinoma and so awareness of surgeons, pathologists, and radiologists is essential to avoid unnecessary mastectomies. Cases of IGM are reported during antidepressant therapy in patients also showing high levels of prolactinemia. In these cases, we believe that surgical excision must be avoided being replaced with a conservative management of the pathological condition based on a corticosteroid treatment.
Breast
;
Foreign-Body Reaction
;
Granulomatous Mastitis
;
Humans
;
Hydrazines
;
Hyperprolactinemia
;
Immunoglobulin M
;
Mastectomy
;
Sarcoidosis
;
Serotonin Uptake Inhibitors
;
Tuberculosis