1.Management of a Pregnant Patient with Graves' Disease Complicated by Propylthiouracil induced Agranulocytosis.
Yoon Young CHO ; Ho Sang SHON ; Hyun Dae YOON
The Korean Journal of Internal Medicine 2005;20(4):335-338
Relapse and exacerbation of Graves' disease during pregnancy is rare, and thionamide induced agranulocytosis is an uncommon side effect. We report a case of a pregnant woman in her 24th week of gestation that experienced a relapse of Graves' disease that was complicated by propylthiouracil induced agranulocytosis. Following the discontinuation of propylthiouracil and administration of a broad-spectrum of antibiotics, agranulocytosis subsided within 10 days. A total thyroidectomy to avoid any future relapse was planned and a short course of a beta-adrenergic blocker and Lugol solution were prescribed before the operation. At the 28th week of gestation, a total thyroidectomy was performed without complications and thyroxine replacement therapy was commenced. At the 40th week of gestation, labor was induced and a 3, 370 g healthy male infant was born without clinical features of thyrotoxicosis. We report herein on the patient and the treatment options for this rare and complicated case.
Thyroidectomy
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Recurrence
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Propylthiouracil/administration & dosage/*adverse effects
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Pregnancy Complications/*therapy
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Pregnancy
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Humans
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Graves Disease/*complications/*therapy
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Female
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Antithyroid Agents/administration & dosage/*adverse effects
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Agranulocytosis/chemically induced/*complications
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Adult
2.Effect of universal salt iodization on antithyroid drugs.
Wei-xin DAI ; Xiao-lan LIAN ; Lin LU ; Su-mei LI ; Shu-hua LI ; Xiu-wei LI
Chinese Medical Journal 2006;119(13):1108-1112
Adolescent
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Adult
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Aged
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Antithyroid Agents
;
therapeutic use
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Female
;
Graves Disease
;
blood
;
drug therapy
;
Humans
;
Iodides
;
urine
;
Iodine
;
administration & dosage
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Male
;
Middle Aged
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Propylthiouracil
;
therapeutic use
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Prospective Studies
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Sodium Chloride, Dietary
;
administration & dosage
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Thyroid Hormones
;
blood
3.Safety and short-term effect of antithyroid agents on hyperthyroidism patients coexisting with viral hepatitis.
Tai JIANG ; Kai-Zhong LUO ; Yong-Hong ZHANG ; Hong-Yu LUO ; Jun LIANG ; Meng LIU
Chinese Journal of Hepatology 2010;18(1):59-60
Adolescent
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Adult
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Aged
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Antithyroid Agents
;
administration & dosage
;
adverse effects
;
therapeutic use
;
Biomarkers
;
blood
;
Female
;
Hepatitis B
;
complications
;
pathology
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Hepatitis, Viral, Human
;
complications
;
pathology
;
Humans
;
Hyperthyroidism
;
complications
;
drug therapy
;
Liver Function Tests
;
Male
;
Methimazole
;
administration & dosage
;
adverse effects
;
therapeutic use
;
Middle Aged
;
Propylthiouracil
;
administration & dosage
;
adverse effects
;
therapeutic use
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Retrospective Studies
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Severity of Illness Index
;
Thyroid Function Tests
;
Young Adult
4.Clinical effect of prunrllae oral solution in treating hyperthyrea.
Kun YANG ; Kun-quan GUO ; Hai-yan WU ; Lin-xiu YE ; Hui XIA
China Journal of Chinese Materia Medica 2007;32(16):1706-1708
OBJECTIVETo observe the clinical effects of prunrllae oral solution in treating hyperthyrea.
METHOD56 cases with hyperthyrea were randomized into two groups; group A1 was treated by classic method, B1 was treated by classic method combined with prunrllae oral solution. The size, vessel caliber of thyroidea, volume of blood flow and blood flow rate pre-and post-treatment were measured by color supersonic, meanwhile, 20 normal thyroidea were measured as control group.
RESULTThe size and vessel caliber of thyroidea of the two groups pre-treatment were obviously bigger than those of the control group, the volume of blood flow and blood flow rate were obviously slower than those of the control group (P < 0.001), the sizes of thyroidea of the two groups became smaller, especially the group B1 was more obvious, and there was no significant difference in the size of thyroidea between group B1 and control group.
CONCLUSIONIt is indicated that combined treatment of traditional Chinese medicine (prunrllae oral solution) and western medicine is superior to western medicine in treating hyperthyrea.
Administration, Oral ; Adult ; Antithyroid Agents ; therapeutic use ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; administration & dosage ; isolation & purification ; therapeutic use ; Female ; Graves Disease ; drug therapy ; pathology ; Humans ; Hyperthyroidism ; drug therapy ; pathology ; Male ; Methimazole ; therapeutic use ; Middle Aged ; Phytotherapy ; Plants, Medicinal ; chemistry ; Prunella ; chemistry ; Thyroid Gland ; drug effects ; pathology