1.Efficacy and safety of edaravone dexcamphenol in the treatment of acute cerebral infarction
Qianqian WANG ; Bin LIU ; Juan GUO
Journal of Apoplexy and Nervous Diseases 2022;39(4):333-335
Objective To investigate the efficacy and safety of edaravone dexcamphenol in the treatment of acute cerebral infarction.Methods Patients with acute cerebral infarction were randomly divided into observation group (edaravone dexborneol+conventional treatment) and control group (conventional treatment) for 14 days.Neurological function was assessed by the National Institutes of Health Stroke Scale (NIHSS) at admission and the modified Rankin Scale (mRS) at 14 days after treatment,respectively.C-reactive protein (CRP) level was detected simultaneously.Furthermore,the occurrence of adverse drug reactions during treatment was observed.Results NIHSS score,mRS score and CRP levels in experimental group were significantly lower than those in control group (all P<0.05).No adverse drug reactions in the two groups were observed during treatment.Conclusion Edaravone dexborneol has a significant clinical effect in the treatment of acute cerebral infarction,and the safety of this treatment is relatively high.
2.Surgical approaches of anterior skull base tumors.
Tianduo WANG ; Xiaobin WANG ; Mei LI ; Anting XU ; Ying CHEN
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2007;21(2):50-51
OBJECTIVE:
Study for surgical approaches on anterior skull base tumors.
METHOD:
All 37 cases with anterior skull base tumors were surgically treated. Twenty-one cases were treated with anterior craniofacial approaches: Frontal subcranial combined with total maxillectomy in 8 cases or/with orbital exenteration in 5 cases, combined with lateral rhinotomy in 1 cases, combined with naso translocation with medial maxillectomy in 7 cases. Partial or total maxillary swing combined with naso pyramid translocation in 13 cases. Frontonasal, fronto-orbital and midface degloving in one case respectively.
RESULT:
Of the 27 malignant cases the 3 and 5-year survival rates were 81.9% (22/27) and 62.9% (17/27) respectively, and one tumor free case living well more than 9 years. There were no recurrence in 10 cases with benign tumor.
CONCLUSIONS
Various craniofacial approaches except lateral rhinotomy provide directly satisfactory tumor exposure and facilitate enbloc resection of the naso paranasal sinus tumor with intracranial extension. Partial or total maxillary swing combined with naso pyramid translocation is good for tumor involving the skull base without intracranial invasion. The fronto-nasal pyramid translocation is good for removal of the upper part of nasal tumor with intracranial extension on well developed frontal sinus. The fronto orbital approach is proper for removal of fronto-sphenoid tumor and midface degloving may be used in selected cases.
Adolescent
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Adult
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Aged
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Craniotomy
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methods
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Female
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Frontal Bone
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surgery
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Humans
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Male
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Middle Aged
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Nose
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surgery
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Skull Base
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surgery
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Skull Base Neoplasms
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surgery
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Young Adult
3.Effects of dulaglutide combined with metformin on body metabolism, body fat composition and serum adipokines in obese patients with type 2 diabetes mellitus
Zhiyi MAO ; Xiaoyan WANG ; Xiaoying CHEN ; Yifei TANG
Journal of Pharmaceutical Practice and Service 2024;42(7):305-309
Objective To explore the clinical efficacy of dulaglutide combined with metformin in the treatment of obese patients with type 2 diabetes mellitus(T2DM). Methods A total of 200 obese patients with T2DM who were treated in Shanghai Jiading District Anting Hospital from January 2021 to January 2023 were randomly divided into liraglutide group(n=100)and dulaglutide group(n= 100). The liraglutide group was treated with liraglutide combined with metformin, and the dulaglutide group was treated with dulaglutide combined with metformin. Both groups were treated for 3 months. The body metabolic indexes [fasting blood glucose(FBG), 2 h postprandial blood glucose(2 h PBG), hemoglobin(HbA1 c), total cholesterol(TC), triglyceride(TG)], body fat composition [body fat rate, body mass index, subcutaneous fat rate of limbs, visceral fat index] and serum adipokines(adiponectin, neuropeptide Q(NPQ), asprosin, irisin)levels were compared before treatment and 3 months after treatment. The clinical efficacy and adverse reactions of the two groups were observed. Results After 3 months of treatment, FBG, 2 h PBG, HbAlc, TC, TG, body fat rate, body mass index, subcutaneous fat rate of limbs, visceral fat index and asprosin in the two groups were lower than those before treatment, and those in the dulaglutide group were lower than those in the liraglutide group(P<0.05). After 3 months of treatment, the levels of serum adiponectin, NPQ and irisin in the two groups were higher than those before treatment, and the increase in the dulaglutide group was greater than that in the liraglutide group(P<0.05). The effective rate of dulaglutide group(98.00%)was higher than that of liraglutide group(91.00 %)(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(11.00%, 14.00%)(P>0.05). Conclusion Dulaglutide combined with metformin could improve the metabolic status of obese T2 DM patients, regulate body fat composition and serum adipokines, with significant clinical efficacy and safety.
4.Anatomical and biomechanical analysis of sacral pedicle and lateral mass.
Meng-jun LI ; Guo-qiang DAI ; Dong WANG ; Jin-wu WANG ; Hai-tao JIANG
Chinese Journal of Traumatology 2011;14(1):29-35
OBJECTIVETo study the anatomical and biomechanical features of sacral pedicle and lateral mass so as to provide reference for clinical screw fixation technology of sacral pedicle and lateral mass.
METHODSA total of 60 adult patients'spiral CT images of the sacrum and coccyx were selected randomly. The entry points of sacral pedicle and lateral mass screws were determined, and the screw trajectory was measured using the three dimensional reconstruction method. Meanwhile, the gross anatomy was scrutinized in 15 adult cadaver specimens to determine the sacral pedicle and lateral mass screw entry points. The length, width and angle of sacral pedicle and lateral mass screw trajectory were measured. Eight of 15 cadaver specimens were selected to test the maximal extraction force of sacral pedicle and lateral mass screws. The clinical data of 15 cases treated by pedicle and lateral mass screw technology were collected and analyzed.
RESULTSThe diameter and length of S(1)-S(5) sacral pedicle and lateral mass screw trajectory were regular, with about 20 degree inclination angle. The S(1) pedicle screw entry point was located at the intersection point of the basal lateral part of articular process and median line of transverse process, and no significant difference was found for the maximal extraction force between pedicle and lateral mass screws (P larger than 0.05). The entry points of S(2)-S(5) pedicle screws were located at the intersection point of the line connecting adjacent posterior sacral foramina and median line of the transverse process. The lateral mass screw entry point of S(2)-S(5) was on the median side of intersection point between median line of the transverse process and lateral sacral crest. The maximal extraction force of pedicle screws was significantly greater than that of lateral mass screws (P less than 0.05).
CONCLUSIONBoth the sacral pedicle and the lateral mass screw fixation techniques can offer effective fixation and reconstruction for fracture of the sacrum and coccyx, but pedicle screw fixation may be more convenient, safe and reliable than lateral mass screw fixation.
Adult ; Biomechanical Phenomena ; Bone Screws ; Female ; Fracture Fixation, Internal ; methods ; Humans ; Imaging, Three-Dimensional ; Male ; Sacrum ; anatomy & histology ; physiology ; surgery ; Tomography, X-Ray Computed
5.Analysis of the main causes of death and life loss of elderly people over 60 years old in a community in Shanghai, 2012-2019
Journal of Public Health and Preventive Medicine 2020;31(4):81-84
Objective To analyze the main causes of death among elderly residents aged 60 and above in Huangdu, Jiading District, Shanghai, and to provide evidence for disease prevention and control of the elderly. Methods The mortality rate, potential years of life lost (PYLL), years of life lost rate (PYLLR), and average years of life lost (AYLL) were calculated to evaluate the death characteristics and life loss of the elderly over 60 years old in Huangdu. Results From 2012 to 2019, there were 1 648 deaths among elderly people over 60 years old, and the death rate was 22.56‰. The mortality rate of residents was basically stable over time (P = 0.315). The top five causes of death were tumor, cerebrovascular disease, cardiovascular disease, respiratory diseases, and injury and poisoning, accounting for 81.67% of all deaths. The mortality of tumors and respiratory diseases was higher in males than in females, and the differences were statistically significant (both P<0.001). There were no significant differences in mortality between men and women in cardiovascular, cerebrovascular, and injury and poisoning diseases (P>0.05). Among the causes of death of residents aged 60 and above, the number of years of life lost caused by all causes of death was 5,512.5 (person-years), the rate of years of life lost was 88.69‰, and the average number of years of life lost was 8.14 (years/person). Conclusion Tumor and cardiovascular and cerebrovascular diseases were the main causes of death in the elderly in Huangdu area. Family doctors should be used to strengthen the prevention and control measures for cancer, cardiovascular and cerebrovascular diseases to improve the quality of life of the elderly in the area.
6.Risk factors associated with hypoglycemia in patients with type 2 diabetes mellitus: a community based case-control study
Xu LI ; Jigang YUAN ; Zhangying LUO ; Yan WANG ; Hui XU ; Zhiping SHEN ; Jue LI ; Lijuan ZHANG
Shanghai Journal of Preventive Medicine 2022;34(4):366-370
ObjectiveTo determine the risk factors associated with hypoglycemia in community patients with type 2 diabetes mellitus(T2DM). MethodsA case-control study was performed among 914 patients with T2DM and no medical history of hypoglycemia were selected in the Diabetes Unit of Tongji University School of Medicine Affiliated Anting Community Health Center in 2018. A total of 196 patients with T2DM who had ≥1 hypoglycemia event in the past 12 months were presented as the case group, and 718 patients who did not have any hypoglycemia event during the same period were included as the control group. Medical history, medication, life style, and related factors were collected. Multivariate logistic regression analysis was used to determine the risk factors associated with hypoglycemia. ResultsHistory of coronary heart disease [adjusted odds ratio(aOR)=2.077, 95% CI: 1.293-3.337], renal disease (aOR=4.775, 95% CI: 1.537-14.830), and previous insulin use (aOR =1.765, 95%CI: 1.147-2.716) significantly increased the risk of hypoglycemia, while angiotensin converting enzyme inhibitors(ACEI)(aOR =0.127, 95%CI: 0.044-0.366) and β-receptor blockers (aOR =0.271, 95%CI: 0.119-0.616) decreased the risk of hypoglycemia among diabetic patients. ConclusionIncidence of hypoglycemia in community patients with diabetes is high. History of coronary heart disease and kidney disease, and previous insulin use may increase the risk of hypoglycemia, which warrants further attention by community general practitioners.
7. Application of START method in general practice teaching clinic of Shanghai Huangdu Community Health Service Center
Liang CHEN ; Jing ZHOU ; Tao WANG ; Lina GONG ; Qiang LI ; Xiuping XIA ; Weiwei ZHANG
Chinese Journal of General Practitioners 2020;19(2):154-157
From April 2017 to September 2019, the START (standardized reception, teaching, analysis, research, training) method was adopted to train 50 general practitioners at the community general practice teaching clinic of Shanghai Huangdu Community Health Service Center. After 3 months of training, the progress of clinical competence and teaching ability were assessed. After training, the scores of clinical skills and communication skills were significantly higher than those before training (
8.Anatomical and Biomechanical Study of Sacral Pedicle and Lateral Mass
Meng jun LI ; Guo qiang DAI ; Xin hua ZHAN ; Shuang HAN ; Zhi FENG ; En ming CAI ; Jin wu WANG ; Hai tao JIANG ; Min HUANG ; Guang shan LIAO ; Xiao lin LIU
Journal of Medical Biomechanics 2010;25(3):E217-E223
Objective To study the anatomical and biomechanical features of sacral pedicle and lateral mass to provide evidence for clinical sacral pedicle and lateral mass screw fixation technology. Method 60 adult patient's spiral CT images of sacrum and coccyx were selected randomly. The sacral pedicle and lateral mass screw entry point was determined, and the crew trajectory were measured using the three dimensional reconstruction. Meanwhile, the gross anatomy was done for 15 adult cadavers to determine the sacral pedicle and lateral mass screw entry point. The length, width and angle of sacral pedicle and lateral mass screw trajectory was measured. 8 of 15 cadaver specimens were selected to test for the maximal extraction force for sacral pedicle and lateral mass screws. ResultsThe diameter and length of S1~S5 sacral pedicle and lateral mass screw trajectory are significantly regular, with inclination angle is about 20°. The S1 pedicle screw entry point is located at intersection point of basal lateral part of articular process and median line of transverse process, no significant difference is found between the maximal extraction force of pedicle and lateral mass screws (P>0.05). The entry points of S2~5 pedicle screws are located at the intersection point of the line connecting adjacent posterior sacral foramina and median line of transverse process. The lateral mass screw entry point of S2~5 is on the median side of intersection point between median line of transverse process and lateral sacral crest. The maximal extraction force of pedicle screws are significantly different from the lateral mass screws(P<0.05). Conclusions Both the sacral pedicle and the lateral mass screw fixation technology can offer effective fixation and reconstruction for the fracture of sacrum and coccyx, but the pedicle screw fixation may be more convenient, safe and reliable than the lateral mass screw fixation technology.
9.Application of Linear Accelerator on Boarding Kilovolt Fan Beam CT and Megavolt Cone Beam CT System on Set-up Errors During Radiation Treatment
Yong ZHOU ; Zeying JIANG ; Baofeng SU ; Jianfeng ZHOU ; Qian WANG ; Anting WANG ; Jingxian LIU ; Yan XUE ; Huiyi FENG ; Xiaoliang WU ; Mingxing XIAO ; Wenyong TAN
Cancer Research on Prevention and Treatment 2023;50(11):1097-1102
Objective To quantify the setup errors for the different anatomical sites of patients who received intensity-modulated radiotherapy (IMRT) with linear accelerator on-board kilovolt fan beam CT(kV-FBCT) as non-isocenter IGRT and megavolt cone beam CT (MV-CBCT) as isocenter IGRT. Methods A retrospective analysis was performedon 70 patients who underwent radiotherapy, kV-FBCT, and/or MV-CBCT scans after each routine setup prior to IMRT. The average displacement (M), systematic error (Σ), and random error (б) at different treatment sites in the left-right, anterior-posterior, and cranial-caudal directions were calculated according to the individual displacements. The formula 2.5Σ+0.7б was used to estimate the PTV margin in respective direction. For each single patient, the root mean square in three directions was used as 3D displacement. Results A total of 1130 displacements were recorded in the 70 patients. The PTV margin was estimated to be 1.9-3.1 mm in head and neck cancer, 2.8-5.1 mm in thoracic cancer, 4.6-5.1 mm in breast cancer, 3.0-5.5 mm in upper abdominal cancer, and 3.5-6.8 mm in pelvic tumor. For the 3D mean displacements, the head and neck, thoracic, breast, upper abdominal, and pelvic cancer were 2.4±1.0, 4.0±1.6, 4.1±2.0, 4.6±2.1, and 4.6±2.1 mm, respectively. The average 3D displacement obtained by kV-FBCT and MV-CBCT were 4.1 and 3.4 mm, respectively (
10.Cochlear implantation in bilateral traumatic severe to profound sensorineural deafness.
Na WANG ; Anting XU ; Email: XUANTING1225@SINA.COM. ; Feng LI ; Yanni YU
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2015;50(4):324-327
OBJECTIVETo analyze the audiologic results of cochlear implantation in bilateral severe to profound sensorineural hearing loss following head trauma.
METHODSA retrospective study of our cochlear implantation cases in bilateral severe to profound sensorineural hearing loss following head trauma (with or without temporal bone fractures). Four patients in second hospital of Shandong university were analyzed in this study.
RESULTSAll the patients received unilateral cochlear implantation and gained open-set speech perception ranging from 92% to 100%. The aided hearing threshold ranged from 30 dBHL to 35 dBHL. None of them experienced a decrease in the hearing performance in the follow-up (1-2 years).
CONCLUSIONWith sufficient preoperative assessment, cochlear implantation is an effective management for hearing rehabilitation in bilateral severe to profound sensorineural hearing loss following head trauma.
China ; Cochlear Implantation ; Craniocerebral Trauma ; Hearing ; Hearing Loss, Bilateral ; Hearing Loss, Sensorineural ; surgery ; Hearing Tests ; Humans ; Retrospective Studies ; Speech Perception