1.Clinical Research Progress on Transformed Lymphoma -Review.
Bing-Jie WANG ; Xi-Nan CEN ; Han-Yun REN
Journal of Experimental Hematology 2016;24(4):1232-1236
Histologic transformation (HT) is a frequent event in the clinical course of patients with indolent lymphoma with dismal outcome. The diagnosis of HT is based on clinical manifestation, PET-CT and pathologic biopsy, and the latter is a golden standard for HT. There are contradictory data about the impact of initial management on the risk of transformation. Patients who present with HT did not receive R-CHOP or chemotherapy-naive, should receive this regimen. For the subset of patients received R-CHOP prior to HT, the second line chemotherapy for DLBCL should be adopted. Consolidation with HDT-ASCT should be considered for the suitable young patients. The radio-immunotherapy and novel drugs showed a bright perspective for the patients with HT.
Antineoplastic Combined Chemotherapy Protocols
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Humans
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Lymphoma, Non-Hodgkin
2.Progress of research on clarithromycin for treatment of multiple myeloma.
Journal of Experimental Hematology 2015;23(1):246-249
Clarithromycin is a 14-membered ring macrolide antibiotics that is widely used in the treatment of infectious disease. Several clinical investigations showed that clarithromycin was highly efficient for multiple myeloma in improving response rate and survival when used in combination with the conventional chemotherapy since 1997. This finding highlights the importance of clarithromycin on the treatment of multiple myeloma. It offers a new regimen for the relapsed/refractory multiple myeloma patients, and provids a new thought for the treatment of multiple myeloma. However, its related mechanism is still unclear, and more investigations are needed. This review summerizes the recent research progress of clarithromycin for treatment of multiple myeloma and its potential mechanisms.
Antineoplastic Combined Chemotherapy Protocols
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Clarithromycin
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Humans
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Multiple Myeloma
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Thalidomide
3.Retrospective study of the efficacy and safety of treatment with PDD vs PAD in de novo patients with multiple myiloma.
Ling MA ; Chengcheng FU ; Hui LIU ; Song JIN ; Bin GU ; Shuang YAN ; Panfeng WANG ; Yun XU ; Shengli XUE ; Weiyang LI ; Aining SUN ; Depei WU
Chinese Journal of Hematology 2015;36(4):340-343
6.Development of an Eye Care Protocol for ICU Patients.
Ji Soo YOO ; Won Hee LEE ; So Sun KIM ; Il sun KO ; Eui Geum OH ; Sang Hui CHU ; Ju Hee LEE ; Se Won KANG ; Eun Kyeung SONG ; Soo Jung CHANG ; Bok Hee KIM ; Jung Eun LEE
Journal of Korean Academy of Fundamental Nursing 2008;15(1):34-44
PURPOSE: The purpose of this study was to develop an eye care protocol for intensive care unit (ICU) patients. METHOD: A systematic review was conducted to develop an eye care protocol for ICU patients. Searches were performed using computerized databases (CINAHL, MEDLINE, EBM Review) and citation search from 1996 to January 2007. For the keywords, "eye care", and "randomized controlled trial" were used to identify experimental studies regarding eye care for ICU patients. After reviewing the collected studies, a preliminary eye care protocol algorithm was created. Then, content validity was examined with ophthalmologists and ICU nurses. RESULTS: Six studies were included to serve as a basis for framing of the preliminary algorithm. The final eye care protocol was completed after verifying the preliminary algorithm's content validity. The final eye care protocol was organized in the following manner: 3 items in the assessment stage, 7 items in the no-risk stage, 4 items in the low-risk stage, and 5 items in the high-risk stage. CONCLUSION: The results indicate that, for ICU patients, nurses can broaden their knowledge regarding ocular diseases, as well as improve their practice-based eye care nursing performance.
Antineoplastic Combined Chemotherapy Protocols
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Clinical Protocols
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Cytarabine
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Etoposide
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Eye
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Humans
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Intensive Care Units
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Methotrexate
7.Chemotherapy selection through the process of gastric cancer.
Chinese Journal of Gastrointestinal Surgery 2012;15(2):118-120
The role of chemotherapy has become more and more important in the whole process of gastric cancer. S-1 or XELOX regimen is regarded as the standard treatment option in adjuvant chemotherapy. First-line chemotherapy in advanced gastric cancer has been established to improve survival, and the benefit from second-line chemotherapy is being acknowledged. More studies are needed to assess the neoadjuvant chemotherapy.
Antineoplastic Combined Chemotherapy Protocols
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administration & dosage
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therapeutic use
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Chemotherapy, Adjuvant
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Humans
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Stomach Neoplasms
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drug therapy
8.Effect of S-1 maintenance chemotherapy following DCF regimen in patients with advanced gastric cancer.
Jinghua CHEN ; Weixi SHEN ; Junxian XIA ; Ruilian XU ; Meiqin ZHU ; Min XU
Journal of Southern Medical University 2014;34(7):1057-1060
OBJECTIVETo investigate the efficacy and adverse effect of DCF regimen with subsequent S-1 maintenance chemotherapy in patients with advanced gastric cancer (AGC).
METHODSSixty AGC patients without disease progression after 4 to 6 cycles of DCF regimen as the first-line chemotherapy were randomized into maintenance group and control group (30 patients each). The patients in the maintenance group received maintenance chemotherapy with S-1 (40 mg/m(2), twice daily for 14 days; 21 days for a treatment cycle) until disease progression or with intolerant toxicity, and those in the control group received optimal supportive care.
RESULTSThe response rate (CR+PR) was 33.3% in the maintenance group, significantly higher than that in the control group (3.33%, P<0.05), and the disease control rate (CR+PR+SD) also differed significantly between the two groups (73.3% vs 46.7%, P<0.05). The median time to progression was 7.9 months in the maintenance group and 6.8 months in the control group, with median overall survival time of 13.8 and 11.7 months, respectively (P>0.05). The most common adverse effect in the maintenance group included nausea, vomiting, leucocytopenia, and hand-foot syndrome; no death occurred in relation to the therapy.
CONCLUSIONS-1 maintenance chemotherapy, with a tolerable toxicity profile, can improve the RR, DCR and median time to progression in AGC patients who respond to DCF regimen, but its efficacy still awaits further evaluation.
Antineoplastic Combined Chemotherapy Protocols ; Humans ; Maintenance Chemotherapy ; Stomach Neoplasms ; drug therapy
9. Familial ovarian cancer: report of ovarian carcinoma in three sisters
G. Kariwiga ; A. B. Amoa ; G. Mola ; S. Heywood
Papua New Guinea medical journal 1997;40(3-4):146-149
This is a report of ovarian carcinoma occurring in two sisters diagnosed almost at the same time, prompting prophylactic oophorectomy in a third sister. Histology of the overtly normal ovary in the third sister showed a focus of ovarian cancer. Discussion and a review of the literature suggest that any program designed to reduce the incidence of late-stage ovarian carcinoma should include the surveillance of family members of the index case, including the performance of prophylactic oophorectomy in the unaffected members of the family after they have completed their families.
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
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Combined Modality Therapy
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Cystadenocarcinoma, Papillary - diagnosis
10.Significance of combination of targeted therapy and immunotherapy in conversion therapy of biliary tract cancer.
Zhao Hui TANG ; Jia Lu CHEN ; Shen Yang LIU ; Xiao Peng YU ; Huan Jun TONG ; Zhi Wei QUAN
Chinese Journal of Surgery 2022;60(4):343-350
Biliary tract cancer has insidious onset and high degree of malignancy, and radical resection is often impossible when it is diagnosed.Conversion therapy can achieve tumor downgrading, so that patients who were initially unresectable have a chance to achieve R0 resection.However, due to the high heterogeneity and complex immune microenvironment of biliary tract cancer, conversion therapy is still in the stage of active exploration.As a new type of conversion therapy, combination of targeted therapy and immunotherapy is of great significance to effectively improve the efficiency of conversion therapy.Further exploration of combination mechanism and improvement of immune microenvironment are expected to become the future direction of combination of targeted therapy and immunotherapy.
Antineoplastic Combined Chemotherapy Protocols
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Biliary Tract Neoplasms/surgery*
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Combined Modality Therapy
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Gastrectomy
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Humans
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Immunotherapy
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Tumor Microenvironment