1.A Case of Reactive Plasmacytosis Mimicking Multiple Myeloma in A Patient with Primary Sjogren's Syndrome.
Jisoo LEE ; Ji Eun CHANG ; Young Joo CHO ; Woon Seop HAN
Journal of Korean Medical Science 2005;20(3):506-508
Primary Sjogren's syndrome (pSS) is a chronic autoimmune disease with welldocumented association of lymphoid malignancies during the progress of the disease. Although several types of malignancy and pseudomalignancy have been reported in pSS, low-grade non-Hodgkin's lymphomas are the most frequently observed. Reactive plasmacytosis mimicking myeloma is a very rare condition in association with pSS. We describe a 72-yr-old woman with pSS who presented with hypergammaglobulinemia, and extensive bone marrow and lymph node plasmacytosis, which mimicked multiple myeloma. In this patient, there was an abnormal differentiation of memory B cells to plasma cells in the peripheral blood suggesting underlying pathogenetic mechanism for this condition.
Aged
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Antigens, CD19/analysis
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Antigens, CD27/analysis
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Bone Marrow Examination
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Diagnosis, Differential
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Female
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Fluorescent Antibody Technique/methods
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Humans
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Multiple Myeloma/*pathology
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Plasma Cells/chemistry/*pathology
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Sjogren's Syndrome/*pathology