OBJECTIVETo evaluate clinical efficacy of herb-partitioned moxibustion with spontaneous heating bag in the treatment of persistent and chronic diarrheal disease (PCDD) of children, and to explore the new treatment protocols for pediatric PCDD.

METHODSOne hundred and twenty cases of PCDD were randomly divided into a herb-partitioned moxibustion group (group M) and a western medicine group (group C), 60 cases in each one. The herb-partitioned moxibustion with spontaneous heating bags was given in the group M, which was placed on the herbal cake at Shenque (CV 8) and Guanyuan (CV 4) for 12 hours, once a day. The group C was orally administrated with smectite powder and live combined bifidobacterium and lactobacillus tablets. Plasma motilin (MOT) level and T cell subset CD4+/CD8+ ratio were observed after 10 days of the treatment, also the clinical efficacy was evaluated.

RESULTSThe cured rate was 53.3% (32/60) in the group M, which was superior to 40.0% (24/60) in the group C (P < 0.05). After the treatment, MOT levels were both decreased (both P < 0.01) while CD4+/CD8+ ratios were both increased (both P < 0.01) in the two groups. The level of MOT in the group M was lower than that in the group C (P < 0.05).

CONCLUSIONThe herb-partitioned moxibustion with spontaneous hea-ting bag has better therapeutic effect than routine western medicine on pediatric PCDD, and it has the advantage of easy manipulation, safety and good compliance of children.

Acupuncture Points ; Adolescent ; Antidiarrheals ; therapeutic use ; Child ; Child, Preschool ; Diarrhea ; drug therapy ; therapy ; Female ; Humans ; Infant ; Male ; Moxibustion ; Probiotics ; therapeutic use ; Silicates ; therapeutic use ; Treatment Outcome

Traditional symptom-based therapies of irritable bowel syndrome (IBS) are directed at the relief of individual IBS symptoms, but they are often of limited efficacy in addressing the entire symptom complex. Combinations of drugs to target bothersome symptoms are suggested as the first-line pharmacologic treatment. Increasing knowledge of the pathophysiology and molecular mechanisms of IBS has resulted in the development of several new therapeutic approaches. Thirteen consensus statements for the treatment of IBS were developed using the modified Delphi approach. Exclusion diets have modest efficacy in improving symptoms in some IBS patients. Symptom-based therapies with dietary fiber, bulking agents, laxatives, antispasmodics and laxatives are effective in the improvement of some individual symptoms, e.g. dietary fiber and bulking agents for constipation, laxatives for constipation, antispasmodics for abdominal pain and discomfort, antidiarrheals for diarrhea. 5HT3 receptor antagonists and 5HT4 receptor agonists are effective in the relief of global IBS symptoms and individual symptoms such as abdominal pain and abnormal bowel habits. A short term course of nonabsorbable antibiotics may improve global IBS symptoms, particularly in patients with diarrhea- predominant IBS. Some probiotics appear to have the potential benefit in improving global IBS symptoms. Selective C-2 chloride channel activator is more effective than placebo at relieving global IBS symptoms in patients with constipation-predominant IBS. Both tricyclic antidepressants and selective serotonin reuptake inhibitors are equally effective in relieving global IBS symptoms, and have some benefits in treating abdominal pain. Certain types of psychologic therapy may be effective in improving global symptoms in some IBS patients. Further studies are strongly needed to develop better treatment strategies for Korean patients with IBS.
Anti-Infective Agents/therapeutic use ; Antidepressive Agents/therapeutic use ; Antidiarrheals/therapeutic use ; Dietary Fiber/therapeutic use ; Humans ; Irritable Bowel Syndrome/*therapy ; Laxatives/therapeutic use ; Parasympatholytics/therapeutic use ; Probiotics/therapeutic use ; Serotonin 5-HT4 Receptor Agonists/therapeutic use ; Serotonin Antagonists/therapeutic use

A number of herbs belonging to the genus Jatropha of Euphorbiaceae family are noted for their medicinal benefits. The genus Jatropha is one of the prospective biodiesel yielding crops. The plants which have been so far explored include J. curcas, J. gossypifolia, J. glandulifera, J. multifida and J. podagrica. Although, the plants of this genus are widely distributed, there is an exiguity of scientific literature proclaiming the medicinal benefits of the plants belonging to genus Jatropha. The present paper is a pragmatic approach to accrue the findings on this very significant genus.
Analgesics ; pharmacology ; therapeutic use ; Animals ; Anthelmintics ; pharmacology ; therapeutic use ; Anti-Inflammatory Agents ; pharmacology ; therapeutic use ; Anticonvulsants ; pharmacology ; therapeutic use ; Antidiarrheals ; pharmacology ; therapeutic use ; Antineoplastic Agents, Phytogenic ; pharmacology ; therapeutic use ; Drugs, Chinese Herbal ; pharmacology ; therapeutic use ; Humans ; Hypoglycemic Agents ; pharmacology ; therapeutic use ; Jatropha ; chemistry ; classification

No abstract available.
Antidiarrheals/*therapeutic use ; Benzimidazoles/*therapeutic use ; Diabetes Mellitus, Type 2/*complications ; Diarrhea/diagnosis/*drug therapy/etiology/physiopathology ; Endoscopy, Gastrointestinal ; Gastrointestinal Transit/*drug effects ; Humans ; Male ; Middle Aged ; Serotonin 5-HT3 Receptor Antagonists/*therapeutic use ; Treatment Outcome

OBJECTIVETo provide further research with literature evidence of the variety origin, traditional effect and dosage.

METHODTextual research on medicinal works of past dynasties.

RESULTThe origin plants are Pueraria lobata, P. thomosonii and P. eduli. Its present effect is the same as ancient literature. However the fresh juice of the plant used for the treatment of bitter by mad dog and aborticide as literature recorded should be proved by further researches. The dosage is different among past dynasties.

CONCLUSIONAs one of the often used Chinese materia medica, Gegen has a bright prospect.

Anti-Inflammatory Agents, Non-Steroidal ; isolation & purification ; therapeutic use ; Antidiarrheals ; isolation & purification ; therapeutic use ; Drugs, Chinese Herbal ; isolation & purification ; therapeutic use ; Fever ; drug therapy ; Humans ; Phytotherapy ; methods ; trends ; Plants, Medicinal ; chemistry ; classification ; Pueraria ; chemistry ; classification

To explore the effect of Xiaoer Fuxie Waifu powder on gastrointestinal dynamics. In the study, the charcoal powder propelling test was used to observe the effect Xiaoer Fuxie Waifu powder on the intestinal motility of normal mice and deficient diarrheal mice. The results showed that Xiaoer Fuxie Waifu powder had no obvious inhibitory effect on the powder propelling in normal mice, but a remarkable inhibitory effect on deficient diarrheal mice. Afterwards, diarrhea index was used to observe the effect on deficient diarrheal mice. The results showed a good anti-diarrhea effect in deficient diarrheal mice induced by folium sennae. According to the subsequent isolated intestines smooth muscle test, Xiaoer Fuxie Waifu powder showed a competitive antagonism on muscular tension caused by acetyl choline and barium chloride, as well as a certain synergistic action with atropine. Finally, the method of radio-immunity was used to determine the contents of SP and VIP in small intestine of mice, showing that SP and VIP in small intestine of mice were decreased and the motility of intestine was inhibited. In conclusion, both in vitro and in vivo experiments indicate that Xiaoer Fuxie Waifu powder is a good traditional Chinese gastrointestinal dynamic medicine for external application, with an anti-diarrhea effect on diarrhea mice induced by spleen deficiency and diarrhea.
Animals ; Antidiarrheals ; therapeutic use ; Diarrhea ; drug therapy ; Drugs, Chinese Herbal ; administration & dosage ; Gastrointestinal Motility ; drug effects ; Gastrointestinal Tract ; drug effects ; Medicine, Chinese Traditional ; methods ; Mice ; Powders ; administration & dosage

Not only the evolution of the processing of Fructus Crataegi, but also the difference of chemical consitituents, pharmacological effects and clinical application before and after the processing are reviewed, based on 26 references of literature. A way to further study the processing of Fructus Crataegi is provided.
Antidiarrheals ; therapeutic use ; Citric Acid ; analysis ; Crataegus ; chemistry ; Diarrhea ; drug therapy ; Drugs, Chinese Herbal ; chemistry ; pharmacology ; therapeutic use ; Flavones ; analysis ; Fruit ; chemistry ; Hot Temperature ; Humans ; Phytotherapy ; Plants, Medicinal ; chemistry ; Technology, Pharmaceutical ; methods ; Trace Elements ; analysis

This study was aimed at evaluating the anti-diabetic potential of passion fruit Passiflora edulis (EPE) extracts in diabetic rats, following Streptozotocin (STZ) induced oxidative stress. Thirty adult Wistar rats were divided into five groups, with six rats in each group. The control rats were injected intraperitoneally with citrate buffer (pH 4.5). The remaining groups of rats were administered single dose of 45 mg·kg(-1) of STZ by intraperitoneal route to induce diabetes. The diabetic animals were treated with 250 and 500 mg·kg(-1) of EPE and glibenclamide 0.6 mg·kg(-1) for fifteen days by oral route. Blood glucose, end organ oxidative stress marker, and anti-oxidants were assayed. Further, histopathological investigation of pancreas was studied at the end of the experimentation. The results revealed that subacute administration of EPE significantly (P < 0.001) controlled the blood glucose level in the diabetic rats. In addition, EPE extract protected the end organs by restoring the anti-oxidants enzyme, significantly increasing super oxide dismutase level (SOD) and decreasing catalase (CAT) and TBARS level in visceral organs. In conclusion, that EPE extracts showed anti-diabetic and anti-oxidant potential against streptozotocin-induced diabetes.
Animals ; Antidiarrheals ; pharmacology ; therapeutic use ; Antioxidants ; metabolism ; pharmacology ; therapeutic use ; Blood Glucose ; metabolism ; Catalase ; metabolism ; Diabetes Mellitus, Experimental ; drug therapy ; metabolism ; pathology ; Female ; Fruit ; Insulin ; blood ; Male ; Oxidative Stress ; drug effects ; Pancreas ; drug effects ; pathology ; Passiflora ; Phytotherapy ; Plant Extracts ; pharmacology ; therapeutic use ; Rats, Wistar ; Seeds ; Superoxide Dismutase ; metabolism