1.The pattern of antinuclear antibody and the positive rate of anti-Scl-70 in systemic sclerosis.
Korean Journal of Medicine 2000;58(3):340-341
No abstract available.
Antibodies, Antinuclear*
;
Scleroderma, Systemic*
2.Frequency of Antinuclear Antibody Positivity in Patients with Pattern Hair Loss.
Won Joon CHOI ; Jung Eun KIM ; Hoon KANG
Annals of Dermatology 2015;27(2):210-212
No abstract available.
Antibodies, Antinuclear*
;
Hair*
;
Humans
3.Deep Dermatophytosis Induced by Trichophyton rubrum.
Korean Journal of Dermatology 2015;53(8):666-667
No abstract available.
Antibodies, Antinuclear
;
Tinea*
;
Trichophyton*
4.Rheumatoid Pseudocyst (geodes) of Anterior Inferior Iliac Spine: A Case Report.
Jai Hyung PARK ; Joo Hak KIM ; Hyung Soo KIM ; Soo Tae CHUNG ; Jeong Hyun YOO ; Seung Do CHA ; Sang Yeop YI ; Yong Hoon KIM
Journal of the Korean Hip Society 2008;20(3):231-234
Typically, geodes are associated with obvious joint involvement, and they are located in the subchondral portion of the joint. Radiological lucencies are produced by pannus infiltration through a disruption in the subchondral plate, and they present as round or oval cystic areas of various sizes. We report a patient with rheumatoid disease and positive antinuclear antibody who had a geode that did not involve the joint. Considering the mechanism of geode occurrence, this is a very rare report of such a manifestation. As a result, we present a rare case of geode occurrence without joint involvement in the setting of rheumatoid disease.
Antibodies, Antinuclear
;
Humans
;
Joints
5.Antinuclear Antibodies in Patients with Behcet's Disease.
Eun Young CHUN ; Sang Gun PARK ; Young Hun CHO ; Ju Hee LEE ; Kwang Hoon LEE ; Dong Sik BANG ; Eun So LEE ; Sung Nack LEE
Korean Journal of Dermatology 2004;42(5):545-550
BACKGROUND: Behcet's disease has features consistent with an immunopathogenic mechanism, but the autoreactivity in pathogenesis is unclear. OBJECTIVE: This study was to investigate the association of antinuclear antibodies (ANA) with Behcet's disease. METHODS: The patients in this study were diagnosed at Severance Hospital Behcet's Disease Specialty Clinic from May, 1998 to May, 2002. We evaluated the frequency, titers and immunofluorescence patterns of ANA in patients with Behcet's disease, and compared the frequency with a healthy control group. According to the positivity of ANA, we compared the frequency of minor symptoms to investigate the association of the severity of disease with ANA. RESULTS: 1. Of the 554 cases of Behcet's disease, 46 cases (8.3%) were ANA positive, however, of the 271 cases of healthy control group, only 5 cases (1.8%) were ANA positive. (p=0.0003) 2. In ANA titers 38 cases (82.6%) showed low titer (1: 40+, 1: 160-), 5 cases (10.9%) intermediate titer (1: 160+, 1: 640-), and 3 cases high titer (>1: 640+). There was no significant difference in intermediate and high titers between complete (17.9%) and incomplete type (14.3%). 3. In immunofluorescence patterns of ANA, 17 cases (37%) were speckled pattern, 5 cases (10.9%) homogeneous pattern, 3 cases (6.5%) centromere pattern, 2 cases (4.3%) nucleolar pattern and 19 cases (41.3%) unknown pattern. 4. Of 508 cases with negative ANA patients, 272 cases (53.5%) had minor symptoms, however, of 46 cases with positive ANA patients, 14 cases (30.4%) had minor symptoms (p=0.0027). CONCLUSION: From this study ANA was more prevalent in Behcet's disease. However, it was not related to severity of disease and most of them were low titer. ANA, herein, might play a minor role in pathogenesis of Behcet's disease.
Antibodies, Antinuclear*
;
Centromere
;
Fluorescent Antibody Technique
;
Humans
6.Study on the application of number fluorescence density in detecting autoantibodies titer.
Xiaodong PENG ; Ruiwei ZHANG ; Lanlan WANG ; Pingwu ZHANG
Journal of Biomedical Engineering 2002;19(2):221-224
This study was firstly conducted to detect antinuclear antibody(ANA) titer by using number influorescence density analysis assay instead of serum diluted assay. The best camera explore time was selected. Then 4,140 ANA positive sera were detected to determine the relationship between number influorescence density (detected by number camera system Spot 32 and computer analysis software ipwin32) and serum diluted titer. The consistent rates in different ANA patterns used by the two methods were compared. 4 seconds was found to be the best explore time and the relationship between number influorescence density and serum diluted titer was 29-50 vs 1:100, 51-85 vs 1:320, 86-175 vs 1:1000, 176-215 vs 1:3200, 216-237 vs 1:10,000. According to this standard we detected 3140 ANA positive sera by use of the two methods and observed a total consistency rate of 89.4%. The consistency rates of three ANA patterns including speckled, homogenous, mixture of speckled and homogenous were as high as 98.9%, 99.5%, 99.8% respectively. The lower consistency rate patterns included nucleolar (5.3%), centromere (1.8%), ribosome(12.6%) and other special patterns(0%). For practical purpose, number influorescence density analysis assay can be used in detecting the three main ANA patterns (speckled, homogeneous, mixture of speckled and homogenous) titer instead of serum diluted assay. The number influorescence density analysis assay is more objective, economical and simple than the serum diluted assay.
Antibodies, Antinuclear
;
analysis
;
Fluorescence
;
Fluoroimmunoassay
;
methods
;
Software
7.A Case of Propylthiouracil-Induced Lupus.
Jaechun LEE ; Bin YOO ; Yun Jeong LIM ; Seong Ho KIM ; Mikyung LIM ; You Sook CHO ; Young Kee SHONG ; Hee Bom MOON
The Journal of the Korean Rheumatism Association 1999;6(1):75-78
Propylthiouracil(PTU) is one of lupus-inducing drugs, though rarely reported. We report a case of PTU-induced lupus, with the review of of previous literatures. Lupus-like symptoms in a 28year-old female patient, who had been suffering from relapsed Graves' disease, were presented during PTU therapy. The results of antinuclear antibody and anti-histone antibody were positive. After symptomatic reatment and discontinuation of PTU, all of the symptoms and the abnormalities in laboratory tests disappeared, which suggested drug-induced lupus.
Antibodies, Antinuclear
;
Female
;
Graves Disease
;
Humans
;
Propylthiouracil
8.Anti-nuclear antibodies in some arthropathy
Journal of Medical and Pharmaceutical Information 1998;(1):27-29
Testing for antinuclear antibodies are useful in evaluation of autoimmune disorders. Anti-nuclear antibodies are detected by a variety of techniques including indirect immuno-fluorescence, enzyme immuno-fluorescence, enzyme immunocytochemistry, and ELISA. In this study, anti-n-DAN quick test was performed on 127 patients who are treated at Rheumatology Department of Bach Mai Hospital from December 1997 to February 1999. Diagnosis in each of these disorders was based on the American College of Rheumatology criteria (ACR). The results shown that, anti-n-nDNA was positive in 84.6% patients with systemic lupus erythematosus (SLE), 24.4% patients with systemic sclerosis and only 8.3% patients with rheumatoid arthritis, respectively. Anti-n-DNA quick test is simply and easy to perform but specificity and sensitivity of this method are still limited to compare with others.
Antibodies, Antinuclear
;
Autoimmune Diseases
;
diagnosis
;
therapeutics
9.Four cases of autoimmune cholangitis.
Seung Kyu CHUNG ; Jae Young JANG ; Soung Won JEONG ; Chan Sup SHIM ; Boo Sung KIM ; Yoon Mi JEEN ; So Young JIN
Korean Journal of Medicine 2009;77(6):750-754
Autoimmune cholangitis is a disease with clinicopathologic features of primary biliary cirrhosis without antimitochondrial antibodies and, frequently, with high antinuclear antibody titers. Alternative terms have been suggested, including antimitochondrial antibody-negative primary biliary cirrhosis, immunocholangitis, autoimmune cholangiopathy, and autoimmune hepatobiliary overlap syndrome type 1. The question of whether autoimmune cholangitis is distinct from primary biliary cirrhosis and autoimmune hepatitis or is an antimitochondrial antibody-negative variant of primary biliary cirrhosis and autoimmune hepatitis is controversial. This case report describes the clinical, immunohistochemical, and pathological findings in four patients with autoimmune cholangitis and reviews the literature.
Antibodies
;
Antibodies, Antinuclear
;
Cholangitis
;
Hepatitis, Autoimmune
;
Humans
;
Liver Cirrhosis, Biliary
10.Four cases of autoimmune cholangitis.
Seung Kyu CHUNG ; Jae Young JANG ; Soung Won JEONG ; Chan Sup SHIM ; Boo Sung KIM ; Yoon Mi JEEN ; So Young JIN
Korean Journal of Medicine 2009;77(6):750-754
Autoimmune cholangitis is a disease with clinicopathologic features of primary biliary cirrhosis without antimitochondrial antibodies and, frequently, with high antinuclear antibody titers. Alternative terms have been suggested, including antimitochondrial antibody-negative primary biliary cirrhosis, immunocholangitis, autoimmune cholangiopathy, and autoimmune hepatobiliary overlap syndrome type 1. The question of whether autoimmune cholangitis is distinct from primary biliary cirrhosis and autoimmune hepatitis or is an antimitochondrial antibody-negative variant of primary biliary cirrhosis and autoimmune hepatitis is controversial. This case report describes the clinical, immunohistochemical, and pathological findings in four patients with autoimmune cholangitis and reviews the literature.
Antibodies
;
Antibodies, Antinuclear
;
Cholangitis
;
Hepatitis, Autoimmune
;
Humans
;
Liver Cirrhosis, Biliary