1.EDTA-dependent Pseudothrombocytopenia Confirmed by Supplementation of Kanamycin: A Case Report.
Hae Lyun AHN ; Young Il JO ; Young Suk CHOI ; Jung Yeon LEE ; Hae Woon LEE ; Seong Ryul KIM ; Joon SIM ; Weon LEE ; Chun Jo JIN
The Korean Journal of Internal Medicine 2002;17(1):65-68
EDTA-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a spurious low platelet count due to EDTA-induced aggregation of platelets. Since the failure to recognize EDTA-dependent PTCP may result in incorrect diagnosis and inappropriate treatment, the recognition of this phenomenon is very important. We report an insidious case of EDTA-dependent PTCP confirmed by supplementation of kanamycin to anticoagulant in a 53-year-old women. Although sodium citrate and heparin usually prevented the aggregation of platelets in EDTA-dependent PTCP patients, these anticoagulants failed in preventing PTCP in our case. EDTA-dependent PTCP was confirmed by the findings that the clumping of platelets on microscopic evaluation was found in EDTA-anticoagulated blood samples, whereas thrombocytopenia and platelet aggregation were not revealed in the sample supplemented with kanamycin.
Antibiotics, Aminoglycoside/*pharmacology
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Anticoagulants/*adverse effects/pharmacology
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Case Report
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Edetic Acid/*adverse effects
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Female
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Human
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Kanamycin/*pharmacology
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Middle Age
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Platelet Aggregation/*drug effects
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Platelet Aggregation Inhibitors/*therapeutic use
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Platelet Count
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Thrombocytopenia/*blood/chemically induced