1.Research progress on chemical constituents and pharmacological activities of halogenated sesquiterpenes from natural sources.
Hua-Wei LYU ; Ji-Ye ZHANG ; Hai CAI ; Hui-Min LIANG ; Xing-Nuo LI
China Journal of Chinese Materia Medica 2023;48(18):4919-4941
Halogenated sesquiterpenes are important derivatives of sesquiterpenes, referring to chemical components of sesquiterpenes that contain halogens such as chlorine, bromine, and iodine. Halogenated sesquiterpenes have attracted attention from researchers in China and abroad because of their diverse structures, unique halogen elements, and extensive pharmacological activities. Studies have shown that halogenated sesquiterpenes exhibit significant antimicrobial, anti-inflammatory, anticancer, insecticidal, hypoglycemic, and enzyme inhibitory activities. In order to better explore the potential pharmaceutical value of halogenated sesquiterpenes, this paper reviewed the structural characteristics and pharmacological activities of halogenated sesquiterpenes in the past two decades, aiming to provide references for further research and development of this class of compounds.
Sesquiterpenes/chemistry*
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Anti-Inflammatory Agents/pharmacology*
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China
2.Reviews on natural monocyclic sesquiterpenoids and their bioactivities.
Jia FU ; Feng-Hua LI ; Chang-Kang LI ; Bao-Ming LI ; Ruo-Yun CHEN ; Jie KANG
China Journal of Chinese Materia Medica 2019;44(17):3672-3683
Sesquiterpenes are a class of terpenoids composed of three isoprene units( 15 carbons). Sesquiterpenoids possess a variety of different structures,including acyclic sesquiterpenes,monocyclic sesquiterpenoids,bicyclic sesquiterpenoids,tricyclic sesquiterpenoids,tetracyclic sesquiterpenoids and macrocyclic sesquiterpenoids. Among them,a large number of monocyclic sesquiterpenoids were isolated and display extensive bioactivities,such as cytotoxic,antioxidant,anti-inflammatory,antibacterial and other activities. In this review,we summarized the progress about the phytochemistry and biological activities of monocyclic sesquiterpenoids( a total of161 compounds) reported from 2014 to 2018( 5 years),including megastigmanes,monocyclofarnesol-type,bisabolane-type,germacrane-type,and other types of monocyclic sesquiterpenoids. Furthermore,several future research perspectives and development of sesquiterpenoids as potential therapeutic agents were discussed as well.
Anti-Bacterial Agents
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pharmacology
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Anti-Inflammatory Agents
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pharmacology
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Antioxidants
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pharmacology
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Molecular Structure
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Sesquiterpenes
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pharmacology
3.Phenylpropanoids from Zanthoxylum species and their pharmacological activities: a review.
Hai-Mei YUAN ; Lu QIU ; Yu SONG ; Liang ZOU ; Long-Fei YANG ; Qiang FU
China Journal of Chinese Materia Medica 2021;46(22):5760-5772
Phenylpropanoids are one of the major chemical constituents in Zanthoxylum species. They include simple phenylpropanoids, coumarins, and lignans and possess anti-tumor, anti-inflammatory, anti-platelet aggregation, anti-bacterial, anti-viral, insecticidal, and antifeedant activities. This review summarizes the chemical constituents and pharmacological activities from the Zanthoxylum plants in hopes of providing reference for the research and application of phenylpropanoids from this genus.
Anti-Inflammatory Agents/pharmacology*
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Coumarins/pharmacology*
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Lignans
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Plant Extracts
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Zanthoxylum
4.Pterocarpans and their biological activities: a review.
China Journal of Chinese Materia Medica 2021;46(17):4323-4333
Pterocarpans, ubiquitous in Fabaceae, are protective active substances produced by the chemical defense system of plants. A total of 144 pterocarpans had been discovered before 2006. For the first time, we reported the 89 pterocarpans identified in 2006-2020. These pterocarpans not only demonstrate novel complex diversified genus-specific stereostructures but also display strong anti-microbial, anti-tumor, antioxidant, insecticidal, and anti-inflammatory activities. Through the projection of their biogenetic pathways and study of the pharmacological activities, the structure-activity correlation was further confirmed. The distribution of Leguminosae plants rich in pterocarpans has obvious regional characteristics. Therefore, the research and utilization of Leguminosae plant resources in China should be strengthened, and the popularity and application value of the geographical indicator plant resources should be improved. This paper serves as a reference for further research, development, and utilization of pterocarpans and their plant sources.
Anti-Inflammatory Agents
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Antioxidants
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Fabaceae
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Plant Extracts/pharmacology*
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Pterocarpans/pharmacology*
5.Research progress of bioactivity of steroidal saponins in recent ten years.
Xing LIU ; Jiang-li YU ; Min LIU ; Ji-cheng SHU ; Hui-lian HUANG
China Journal of Chinese Materia Medica 2015;40(13):2518-2523
Steroidal saponins have a wide range of pharmacological effects and biological activities, such as anti-tumor, antifungal, hypoglycemic, immune regulation, insecticides, etc. In the last ten years, some new structures of steroidal saponins compounds were found from natural plants, they have some new and different activities. In order to accelerate the research on the drug innovation of steroidal saponins, we summarized the new progress of the research on such compounds.
Animals
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Anti-Inflammatory Agents
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pharmacology
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Antifungal Agents
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pharmacology
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Antineoplastic Agents, Phytogenic
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pharmacology
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Humans
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Hypoglycemic Agents
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pharmacology
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Saponins
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pharmacology
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Steroids
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pharmacology
6.Research progress on sesquiterpenes and its pharmacological activities in genus Carpesium.
Di-Lu CHEN ; Xuan LI ; Xiao-Jiang ZHOU
China Journal of Chinese Materia Medica 2020;45(1):37-51
The genus Carpesium plants contain many kinds of sesquiterpenes. Up to now, more than 201 sesquiterpene compounds have been isolated and identified, including 86 germacranolides, 30 eudesmanolides, 29 guaianolides, 23 sesquiterpene dimers, 9 pseudoguaianes, 9 carabranolides, 7 xanthanolides, 6 sesquiterpenes without lactone, 1 eremophilane and 1 tricyclo dodecane sesquiterpene. The reported sesquiterpenes possess a series of pharmacological properties, such as anti-tumor, anti-inflammatory, antibacterial, antiparasitic, insecticidal, and antiviral activities. This paper summarizes the 201 chemical structures and biological activities of sesquiterpenes in genus Carpesium, and provides the scientific basis for the further development and utilization.
Anti-Bacterial Agents
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Anti-Inflammatory Agents
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Asteraceae/chemistry*
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Lactones
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Molecular Structure
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Phytochemicals/pharmacology*
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Sesquiterpenes/pharmacology*
7.A review of structural modification and biological activities of oleanolic acid.
Huali YANG ; Minghui DENG ; Hongwei JIA ; Kaicheng ZHANG ; Yang LIU ; Maosheng CHENG ; Wei XIAO
Chinese Journal of Natural Medicines (English Ed.) 2024;22(1):15-30
Oleanolic acid (OA), a pentacyclic triterpenoid, exhibits a broad spectrum of biological activities, including antitumor, antiviral, antibacterial, anti-inflammatory, hepatoprotective, hypoglycemic, and hypolipidemic effects. Since its initial isolation and identification, numerous studies have reported on the structural modifications and pharmacological activities of OA and its derivatives. Despite this, there has been a dearth of comprehensive reviews in the past two decades, leading to challenges in subsequent research on OA. Based on the main biological activities of OA, this paper comprehensively summarized the modification strategies and structure-activity relationships (SARs) of OA and its derivatives to provide valuable reference for future investigations into OA.
Oleanolic Acid
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Structure-Activity Relationship
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Anti-Inflammatory Agents/pharmacology*
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Triterpenes
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Anti-Bacterial Agents/pharmacology*
8.Research progress on intestinal microecology regulating mechanism and biological activities of polysaccharides.
Ting TANG ; Hua-Guo CHEN ; Chao ZHAO ; Xiao-Jian GONG ; Qing-Fang DENG ; Xin ZHOU
China Journal of Chinese Materia Medica 2021;46(21):5585-5592
Intestinal microecology is an important defense system in the human body. The intestinal flora is the core micro-ecosystem in the human intestine. It has a symbiotic relationship with the overall functions of the body. It has strong metabolic activity to maintain the normal functioning of the body and resist the invasion of various viral antigens in the body. Playing a protective function,the imbalanced intestinal microecology can cause various diseases. Polysaccharides can be extracted from a wide range of sources and have low toxicity and side effects. They have attracted wide attention because of their anti-tumor, anti-oxidant, anti-inflammatory and other biological activities. Studies have demonstrated that polysaccharides can regulate intestinal microecological disorders. According to the studies in recent years, this review summarizes that polysaccharides mainly modulate intestinal microecological disorders through regulating the composition of intestinal flora, improving the metabolism of the flora, and repairing the intestinal tract barrier. On the basis of these mechanisms of action, this paper elaborates the anti-tumor, immunomodulatory, and anti-inflammatory activities of polysaccharides. This paper can provide reference for the future research on the intestinal microecology-regulating mechanism and biological activities of polysaccharides.
Anti-Inflammatory Agents
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Ecosystem
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Gastrointestinal Microbiome
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Humans
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Intestines
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Polysaccharides/pharmacology*
9.Chemical constituents from the leaves of Cinnamomum camphora var. linaloolifera and their anti-inflammatory activities.
Mei-Ting WU ; Shi-Yao LIU ; Da-Long HUANG ; Li-Na HE ; Mao GUO ; Lin NI ; Shuang-Quan ZOU
China Journal of Chinese Materia Medica 2021;46(14):3592-3598
Thirteen compounds were isolated and purified from the leaves of Cinnamomum camphora by the macroporous resin,silica gel,and Sephadex LH-20 column chromatographies. Those compounds were further identified by IR,UV,MS,and NMR techniques:( 2 S)-1-( 3″,4″-methylenedioxy phenyl)-3-( 2',6'-dimethoxy-4'-hydroxyphenyl)-propan-2-ol( 1),( 2 R,3 R)-5,7-dimethoxy-3',4'-methylenedioxy flavanol( 2),9-hydroxysesamin( 3),sesamin( 4),piperitol( 5),kobusin( 6),(-)-aptosimon( 7),acuminatolide( 8),1β,11-dihydroxy-5-eudesmene( 9),lasiodiplodin( 10),vanillin( 11),p-hydroxybenzaldehyde( 12),and p-hydroxybenzoic acid ethyl ester( 13). Compound 1 was a novel compound,and compounds 2,6,7,9 and 10 were isolated from Cinnamomum plants for the first time. Compounds 4,7 and 10 were found to possess good inhibitory effect on IL-6 production in LPS-induced BV2 cells at a concentration of 20 μmol·L-1 in the in vitro bioassay,with inhibition rates of 51. 26% ± 4. 13%,67. 82% ± 3. 77% and85. 81%±1. 19%,respectively.
Anti-Inflammatory Agents/pharmacology*
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Cinnamomum
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Cinnamomum camphora
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Plant Leaves
10.Research progress on chemical constituents and pharmacological activities of Potentilla.
Jia WU ; Zai-Qi ZHANG ; Huang-He YU ; Fei-Bing HUANG ; Zhu-Liang CHEN ; Ling-Ling CHU ; Bin LI ; Wei WANG
China Journal of Chinese Materia Medica 2022;47(6):1509-1538
There are 200-500 species of Potentilla(Rosaceae) worldwide, among which 90 species are widely distributed in China and have a long history of ethnic medicinal use. According to our statistics, a total of 367 compounds have been isolated and identified from plants of this genus, including terpenoids, flavonoids, phenolic acids, tannins, and phenylpropanoids. The medicinal materials made from these plants mainly have antioxidative, blood sugar-lowering, anti-inflammatory, anti-tumor, cardiovascular system-protecting, neuroprotective, and hepatoprotective activities. This study systematically reviews the research progress on chemical constituents and pharmacological activities of Potentilla plants to provide a basis for further research and clinical application.
Anti-Inflammatory Agents/pharmacology*
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Antioxidants/pharmacology*
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Drugs, Chinese Herbal/pharmacology*
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Plant Extracts/pharmacology*
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Potentilla