3.Anti-oxygenation effect of procyanidins in plant medicine.
China Journal of Chinese Materia Medica 2003;28(8):700-702
This article summarized the chemical construction and plant resources, biochemical and pharmacologicaly activity and the anti-oxygenation effect of procyanidins.
Animals
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Anti-Inflammatory Agents, Non-Steroidal
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pharmacology
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Antimutagenic Agents
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pharmacology
;
Antioxidants
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pharmacology
;
Enzyme Inhibitors
;
pharmacology
;
Humans
;
Plants, Medicinal
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chemistry
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Platelet Aggregation Inhibitors
;
pharmacology
;
Proanthocyanidins
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chemistry
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isolation & purification
;
pharmacology
5.Effect of topical nonsteroidal anti-inflammatory drugs versus topical steroids after strabismus surgery.
Journal of the Korean Ophthalmological Society 2003;44(1):115-120
PURPOSE: The purpose of this study is to compare the effect of topical nonsteroidal anti-inflammatory drugs (NSAID) with topical steroid in conjunctival inflammation, wound healing, and intraocular pressure when used after strabismus surgery. METHODS: Twenty five patients who received bilateral horizontal rectus muscle recession were selected. 0.1% prednisolone acetate (Optilon(R), Chongkundang Pharma Corporation) was applied to the right eye of each patient and 0.1% pranoprofen (Pranopulon(R), Choongwae Pharmacology Corporation) was applied to the left eye four times a day after surgery. Both eyes were compared at one day, 1 week, 2 weeks and 4 weeks after surgery to measure the extent of inflammation (injection, chemosis, discharge), pain and conjunctival incisional healing. The intraocular pressure was compared at the day before surgery and 1 week, 2 weeks and 4 weeks after surgery. RESULTS: The steroid group showed earlier improvement of inflammation and pain and faster conjunctival incisional healing than the NSAID group (p>0.1). The steroid group showed a significantly higher IOP than the NSAIDs group throughout the periods (p<0.001), and showed a progressive increasement in IOP during the study periods (p<0.001). CONCLUSIONS: Topical NSAIDs were proved to be as effective as topical steroids in controlling inflammation and pain, and in the healing of conjunctival wounds. In addition, topical NSAIDs showed no side effect of increasing IOP. Therefore, topical NSAIDs may be a safe alternative to topical steroids after strabismus surgery in children who have difficulty in measuring IOP.
Anti-Inflammatory Agents, Non-Steroidal
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Child
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Humans
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Inflammation
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Intraocular Pressure
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Pharmacology
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Prednisolone
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Steroids*
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Strabismus*
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Wound Healing
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Wounds and Injuries
6.Exploring relationship between traditional effects of traditional Chinese medicine and modern pharmacological activities by "co-effect compounds".
Hai-Bo LIU ; Ai-Jun LU ; Bing LIU ; Jia-Ju ZHOU
China Journal of Chinese Materia Medica 2005;30(1):75-78
The compound that distributes in the herbs with one common effect was named as "co-effect compound" (CEC). The CECs of three traditional Chinese medicine(TCM) effects, purgative, relieving pain and clearing heat, had been found and studied. A strong corresponding relationship was found between the pharmacological activities of CECs and the TCM effect they belong to. The study shows that it may be a feasible method to connect traditional effect of TCM with modem pharmacological activity.
Anthraquinones
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isolation & purification
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pharmacology
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Anti-Inflammatory Agents, Non-Steroidal
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pharmacology
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Cathartics
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pharmacology
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Drugs, Chinese Herbal
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isolation & purification
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pharmacology
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Flavonoids
;
isolation & purification
;
pharmacology
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Medicine, Chinese Traditional
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Plants, Medicinal
;
chemistry
9.Comparative studies on pharmacological effects of the main chemical constituents of Peucedanum praeruptorum from He'nan and Jiangxi.
Cun ZHANG ; Wen LI ; Yong-qing XIAO
China Journal of Chinese Materia Medica 2005;30(17):1356-1358
OBJECTIVETo compare the pharmacological effect of the main coumarin constituents of Peucedanum praeruptorum from Jiangxi and He'nan.
METHODThe constituents were isolated by column chromatography on silica gel and ODS and identified by NMR and MS spectroscopic methods. The antitussive, expectorant and anti-inflammatory effects of main coumarin constituents of P. praeruptorum observed in the present study.
RESULTThe main constituents of P. praeruptorum from both Jiangxi and He'nan showed the significant antitussive and anti-inflammatory effects without obviously expectorant effect.
CONCLUSIONThe pharmacological effects of the main coumarin constituents of Qian-hu from Jiangxi and He'nan are similar.
Animals ; Anti-Inflammatory Agents, Non-Steroidal ; isolation & purification ; pharmacology ; Antitussive Agents ; isolation & purification ; pharmacology ; Apiaceae ; chemistry ; China ; Coumarins ; isolation & purification ; pharmacology ; Drugs, Chinese Herbal ; chemistry ; Female ; Male ; Mice
10.Chemical and pharmacological advances of study on Lysimachia.
Hai-tao CHANG ; Wei-liang KONG ; Peng-fei TU
China Journal of Chinese Materia Medica 2004;29(4):295-298
The progress in the research of the chemical components and pharmacological activities of Lysimachia was reviewed. Lysimachia mainly contain flavonoids, saponins and phenolic acids, and some of the plants have been used in the treatment of fever, ulcers, diarrhea and as analgesic or anti-inflammatory agents. The plants of genus Lysimachia are widespread in China, so it is a singificants work to study their chemical ingredients and pharmacological activities.
Animals
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Anti-Inflammatory Agents, Non-Steroidal
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pharmacology
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Antineoplastic Agents, Phytogenic
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pharmacology
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Drugs, Chinese Herbal
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isolation & purification
;
pharmacology
;
Flavonoids
;
isolation & purification
;
Plants, Medicinal
;
chemistry
;
Primulaceae
;
chemistry
;
Saponins
;
isolation & purification