4.The Effect of Non-steroidal Anti-inflammatory Drugs in Upper Gastrointestinal Bleeding.
Sang Woo LEE ; Hak Yang KIM ; Soo Heon PARK ; Ki Baik HAHM ; Jong Myon BAE ; Hyun Chae JUNG ; Jin Ho KIM
The Korean Journal of Gastroenterology 2004;44(1):13-18
BACKGROUND/AIMS: To evaluate the association between non-steroidal anti-inflammatory drugs (NSAIDs) use and upper gastrointestinal (UGI) bleeding, we performed a case-control study at the six University affiliated hospitals for one year. METHODS: Case and control subjects matched for age and sex were selected by endoscopy. Subjects were asked for the use of NSAIDs, past medical history, history of other medications, and smoking. The age and sex adjusted risk for UGI bleeding with NSAIDs use was compared between the case and control groups. RESULTS: The odd ratios of UGI bleeding with NSAIDs intake adjusted for past medical and medication history, past medical history only, and medication history only were 5.0, 5.0, and 1.7, respectively. The cases had significantly more history of NSAIDs intake, more diseases in medical history, and more medications other than NSAIDs compared to the controls. There was no relationship between UGI bleeding and concomitant medications in the both groups. CONCLUSIONS: This multicenter study suggests that a history of NSAIDs intake is strongly associated with UGI bleeding in Korea.
Anti-Inflammatory Agents, Non-Steroidal/*adverse effects
;
Case-Control Studies
;
English Abstract
;
Gastrointestinal Hemorrhage/*chemically induced
;
Humans
6.Preventive strategy for post-ERCP pancreatitis.
Baohong GU ; Xuemei LI ; Jike HU ; Fan ZHANG ; Juanjuan LU ; Hao CHEN
Journal of Central South University(Medical Sciences) 2019;44(2):209-215
Endoscopic retrograde cholangiopancreatography (ERCP) is an irreplaceable measure with minimally invasive diagnosis and treatment of endoscopy for biliary and pancreatic diseases, but the related complications associated with ERCP are the highest among the endoscopic procedures. Post-ERCP pancreatitis (PEP) is one of the most common complications with life-threatening in severe cases. Early active prevention can effectively reduce the incidence of post-ERCP pancreatitis. At present, measures including preoperative rectal non-steroidal anti-inflammatory drugs and prophylactic pancreatic stent placement, have definite effective strategy in clinic. Aggressive hydration with lactated Ringer's solution is also a safe and effective way to prevent PEP.
Anti-Inflammatory Agents, Non-Steroidal
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Cholangiopancreatography, Endoscopic Retrograde
;
adverse effects
;
Humans
;
Incidence
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Pancreatitis
;
etiology
;
Risk Factors
;
Stents
8.Nimesulide-induced hepatotoxicity and fatal hepatic failure.
Singapore medical journal 2008;49(5):436-author reply 438
10.A Case of Acute Pancreatitis Induced by Multiple Drugs in a Patient with Ulcerative Colitis.
Chang Nam SON ; Hang Lak LEE ; Yong Won JOO ; Oh Young LEE ; Dong Soo HAN ; Byung Chul YOON ; Ho Soon CHOI ; Joon Soo HAHM
The Korean Journal of Gastroenterology 2008;52(3):192-195
Acute pancreatitis is a serious disease with fatality rate up to 15%. We recently experienced a case of acute pancreatitis induced by multiple drugs in a patient with ulcerative colitis. A 20-year-old female visited with abdominal pain and hematochezia and diagnosed of ulcerative colitis. Sulfasalazine and prednisolone were used. However, acute pancreatitis occurred after 4 weeks of treatment with additional azathioprine treatment. Drug-induced pancreatitis was suspected, and she was recovered with conventional therapy for acute pancreatitis. Therefore, it was proposed that acute pancreatitis was induced by azathioprine. However, after the administration of sulfasalazine, pancreatitis relapsed. Furthermore, even the re-administration of 5-ASA and azathioprine induced relapse of acute pancreatitis. We concluded that acute pancreatitis was induced by multiple drugs in this patient with ulcerative colitis.
Acute Disease
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Anti-Inflammatory Agents, Non-Steroidal/adverse effects
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Antimetabolites/adverse effects
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Azathioprine/adverse effects
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Colitis, Ulcerative/diagnosis/*drug therapy
;
Colonoscopy
;
Female
;
Humans
;
Mesalamine/adverse effects
;
Pancreatitis/*chemically induced/*diagnosis
;
Sulfasalazine/adverse effects
;
Tomography, X-Ray Computed
;
Young Adult