1.Reviews on natural monocyclic sesquiterpenoids and their bioactivities.
Jia FU ; Feng-Hua LI ; Chang-Kang LI ; Bao-Ming LI ; Ruo-Yun CHEN ; Jie KANG
China Journal of Chinese Materia Medica 2019;44(17):3672-3683
Sesquiterpenes are a class of terpenoids composed of three isoprene units( 15 carbons). Sesquiterpenoids possess a variety of different structures,including acyclic sesquiterpenes,monocyclic sesquiterpenoids,bicyclic sesquiterpenoids,tricyclic sesquiterpenoids,tetracyclic sesquiterpenoids and macrocyclic sesquiterpenoids. Among them,a large number of monocyclic sesquiterpenoids were isolated and display extensive bioactivities,such as cytotoxic,antioxidant,anti-inflammatory,antibacterial and other activities. In this review,we summarized the progress about the phytochemistry and biological activities of monocyclic sesquiterpenoids( a total of161 compounds) reported from 2014 to 2018( 5 years),including megastigmanes,monocyclofarnesol-type,bisabolane-type,germacrane-type,and other types of monocyclic sesquiterpenoids. Furthermore,several future research perspectives and development of sesquiterpenoids as potential therapeutic agents were discussed as well.
Anti-Bacterial Agents
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pharmacology
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Anti-Inflammatory Agents
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pharmacology
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Antioxidants
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pharmacology
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Molecular Structure
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Sesquiterpenes
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pharmacology
3.Advances in several important antimicrobial lipopeptids from Bacillus spp.
Daoming LI ; Ying WANG ; Chao CHEN ; Mingbai ZENG ; Qianru LI ; Qingyun JIA ; Xiuli LIU ; Yongyue HOU ; Chengming FAN ; Yuhong CHEN ; Zanmin HU
Chinese Journal of Biotechnology 2022;38(5):1768-1783
Bacillus spp. are probiotics and can secrete a variety of natural antimicrobiol active substances, of which lipopeptides are an important class. Up to now, about 90 lipopeptides have been identified, and most of them are cyclic lipopeptides. surfactin, iturin, fengycin, bacillomycin and polymyxins are widely studied, and the first three have huge potential for application due to their properties of surfactants and anti-fungal, anti-bacterial, anti-viral, anti-tumor and anti-inflammatory functions. In this paper, the research progress in the structure, function, synthesis regulation, separation, purification and production of surfactin, iturin and fengycin was reviewed. Synthetic biology is a vital means to increase the yield of lipopeptides, and in the future, lipopeptides can be used in crop cultivation, animal farming, food, medicine and petroleum industries as well as environmental protection. Future research should be strengthened on the discovery of new lipopeptides, synthesis of high-activity lipopeptides, economical production of lipopeptides on a large scale and their safety evaluation.
Anti-Bacterial Agents
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Anti-Infective Agents/pharmacology*
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Bacillus
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Bacillus subtilis
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Lipopeptides/pharmacology*
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Peptides, Cyclic/pharmacology*
4.Near-infrared excited graphene oxide/silver nitrate/chitosan coating for improving antibacterial properties of titanium implants.
Yifan WANG ; Yingde XU ; Xuefeng ZHANG ; Jingyu LIU ; Jintong HAN ; Shengli ZHU ; Yanqin LIANG ; Shuilin WU ; Zhenduo CUI ; Weijia LÜ ; Zhaoyang LI
Chinese Journal of Reparative and Reconstructive Surgery 2023;37(8):937-944
OBJECTIVE:
To design and construct a graphene oxide (GO)/silver nitrate (Ag3PO4)/chitosan (CS) composite coating for rapidly killing bacteria and preventing postoperative infection in implant surgery.
METHODS:
GO/Ag3PO4 composites were prepared by ion exchange method, and CS and GO/Ag3PO4 composites were deposited on medical titanium (Ti) sheets successively. The morphology, physical image, photothermal and photocatalytic ability, antibacterial ability, and adhesion to the matrix of the materials were characterized.
RESULTS:
The GO/Ag3PO4 composites were successfully prepared by ion exchange method and the heterogeneous structure of GO/Ag3PO4 was proved by morphology phase test. The heterogeneous structure formed by Ag3PO4 and GO reduced the band gap from 1.79 eV to 1.39 eV which could be excited by 808 nm near-infrared light. The photothermal and photocatalytic experiments proved that the GO/Ag3PO4/CS coating had excellent photothermal and photodynamic properties. In vitro antibacterial experiments showed that the antibacterial rate of the GO/Ag3PO4/CS composite coating against Staphylococcus aureus reached 99.81% after 20 minutes irradiation with 808 nm near-infrared light. At the same time, the composite coating had excellent light stability, which could provide stable and sustained antibacterial effect.
CONCLUSION
GO/Ag3PO4/CS coating can be excited by 808 nm near infrared light to produce reactive oxygen species, which has excellent antibacterial activity under light.
Chitosan
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Silver Nitrate
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Titanium
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Anti-Bacterial Agents/pharmacology*
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Coloring Agents
5.Bacterial stress response, physiological metabolism and antimicrobial tolerance and the control strategies.
Lulu HUANG ; Yufeng GU ; Cuirong WU ; Junhong HUANG ; Guyue CHENG
Chinese Journal of Biotechnology 2020;36(11):2287-2297
Overuse of antibiotics in medical care and animal husbandry has led to the development of bacterial antimicrobial resistance, causing increasingly more health concern. In addition to genetic mutations and the formation of resistance, the various stresses bacteria encountered in the natural environment trigger their stress responses, which not only protect them from these stresses, but also change their tolerance to antimicrobials. The emergence of antimicrobial tolerance will inevitably affect the physiological metabolism of bacteria. However, bacteria can restore their sensitivity to drugs by regulating their own metabolism. This article reviews recent studies on the relationship between bacterial stress responses or the physiological metabolism and antimicrobial tolerance, intending to take more effective measures to control the occurrence and spread of antimicrobial resistance.
Animals
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Anti-Bacterial Agents/pharmacology*
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Anti-Infective Agents
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Bacteria/genetics*
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Drug Resistance, Bacterial
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Stress, Physiological
6.Research progress on sesquiterpenes and its pharmacological activities in genus Carpesium.
Di-Lu CHEN ; Xuan LI ; Xiao-Jiang ZHOU
China Journal of Chinese Materia Medica 2020;45(1):37-51
The genus Carpesium plants contain many kinds of sesquiterpenes. Up to now, more than 201 sesquiterpene compounds have been isolated and identified, including 86 germacranolides, 30 eudesmanolides, 29 guaianolides, 23 sesquiterpene dimers, 9 pseudoguaianes, 9 carabranolides, 7 xanthanolides, 6 sesquiterpenes without lactone, 1 eremophilane and 1 tricyclo dodecane sesquiterpene. The reported sesquiterpenes possess a series of pharmacological properties, such as anti-tumor, anti-inflammatory, antibacterial, antiparasitic, insecticidal, and antiviral activities. This paper summarizes the 201 chemical structures and biological activities of sesquiterpenes in genus Carpesium, and provides the scientific basis for the further development and utilization.
Anti-Bacterial Agents
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Anti-Inflammatory Agents
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Asteraceae/chemistry*
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Lactones
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Molecular Structure
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Phytochemicals/pharmacology*
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Sesquiterpenes/pharmacology*
7.A review of structural modification and biological activities of oleanolic acid.
Huali YANG ; Minghui DENG ; Hongwei JIA ; Kaicheng ZHANG ; Yang LIU ; Maosheng CHENG ; Wei XIAO
Chinese Journal of Natural Medicines (English Ed.) 2024;22(1):15-30
Oleanolic acid (OA), a pentacyclic triterpenoid, exhibits a broad spectrum of biological activities, including antitumor, antiviral, antibacterial, anti-inflammatory, hepatoprotective, hypoglycemic, and hypolipidemic effects. Since its initial isolation and identification, numerous studies have reported on the structural modifications and pharmacological activities of OA and its derivatives. Despite this, there has been a dearth of comprehensive reviews in the past two decades, leading to challenges in subsequent research on OA. Based on the main biological activities of OA, this paper comprehensively summarized the modification strategies and structure-activity relationships (SARs) of OA and its derivatives to provide valuable reference for future investigations into OA.
Oleanolic Acid
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Structure-Activity Relationship
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Anti-Inflammatory Agents/pharmacology*
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Triterpenes
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Anti-Bacterial Agents/pharmacology*
9.Old fusidane-type antibiotics for new challenges: Chemistry and biology.
Chuan TIAN ; Ke WANG ; Xuan ZHANG ; Gang LI ; Hong-Xiang LOU
Chinese Journal of Natural Medicines (English Ed.) 2022;20(2):81-101
The spread of antibiotic-resistant bacteria and exhausted drug leads render some infections untreatable now and in the future. To deal with these "new challenges", scientists tend to re-pick up "old antibiotics". Fusidane-type antibiotics have been known for nearly 80 years as potent antibacterial agents against gram-positive bacteria, especially Staphylococci, and represent the only triterpene-derived antibiotic class in clinical setting. These attractive characteristics have drawn renewed attention on fusidane-type antibiotics in recent decades. Isolation, characterization, biological evaluation, as well as chemical modifications of fusidane-type antibiotics are increasingly being reported. Combinatorial biosynthesis of this type of antibiotics has been successfully utilized not only for elucidating the biosynthetic pathways, but also for expanding their structural diversity. Some isolated and synthetic compounds exhibit comparable or even more potent biological activity than fusidic acid. This review provides an overview of progress on the studies of structure and biology of fusidane-type antibiotics from 1943 to April 2021. The informative structure-activity relationship is also highlighted.
Anti-Bacterial Agents/pharmacology*
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Bacteria
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Biology
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Structure-Activity Relationship
10.Research advance in surface modification of titanium alloys with chitosan.
Jia-Xin LIU ; Li-Ping AN ; Yao-Fei JIA ; Guang-Rui ZHANG ; Jian-Ping ZHOU ; Ding WU ; Ming-Tao ZHANG ; Xiang-Dong YUN
China Journal of Orthopaedics and Traumatology 2020;33(12):1175-1178
Titanium alloy has good biological properties and is commonly used in orthopedics, but its bone integrity and antibacterial properties are poor, so surface modification is needed to make up for its shortcomings. Chitosan has good biocompatibility and film forming ability, and can be used as a carrier to introduce the target drug to the surface of titanium alloy, which can effectively improve the biological properties of titanium alloy materials and increase its application range. In this paper, the related research of chitosan surface modified titanium alloy materials in recent years is summarized. The modification methods of chitosan coating, the improvement of osteogenesisand antibacterial properties of titanium alloy materials are discussed in order to provide guidance for the clinical application of coating modification of titanium alloy materials.
Alloys
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Anti-Bacterial Agents/pharmacology*
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Chitosan
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Orthopedics
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Surface Properties
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Titanium