No abstract available.
Anthracosis* ; Mass Screening*

Anthracosis* ; Coal* ; Humans ; Immunoglobulins

For the evaluation of change of FVC and FEV1 after discontinuance of bronchodilator in the coal workers' pneumoconiosis patients, 17 pairs of patients were selected. They were matched by the age(+/-5 y.o.) and the type of ventilatory impairment. Pulmonary function was measured 2 times bimonthly before and after the drug discontinuance discontinued after measurement of PFT for 2 times. In case group the bronchodilator was discontinued after measurement of PFT for 2 times. In control group there was no interruption of medication. FVC, FEV1 decreased in both group as measurement progress. Simple linear regression coefficients against the month of measurement were calculated in both group and tested for parallelism between two groups. The results of test revealed that both regression coefficients were parallel. So in conclusively, discontinuance of medication of bronchodilator for coal workers pneumoconiosis patients has no effect on the decreasing rate of FVC, FEV1.
Anthracosis ; Coal* ; Humans ; Linear Models ; Pneumoconiosis*

We measured fasting Serum Angiotensin-Converting Enzyme (SACE) in 100 healthy controls and 75 coal worker's pneumoconiosis (CWP) patients by a commercial kits (ACEcolor®, Fujirio Inc., Japan) and evaluated this manual method. The linear range extends to an activity of 80U/L. Precision on a commercial control serum (ACE control-N®, Sigma Co.) with a mean value of 9.47U/L yielded a within-run and between-run CVs are 5.6% (N=15) and 6.9% (N=14) respectively. Save in 75 CWP was 20.3±5.7U/L (mean±s.d.); higher than in healthy controls (13.4±3.9U/L, P<0.01). No correlation was found between SACE, sex, and age. The results suggest that the measurement for SACE and follow-up SACE in coal workers may be a useful diagnostic tools for CWP.
Anthracosis* ; Coal* ; Fasting ; Follow-Up Studies ; Humans ; Methods

Anthracosis ; prevention & control ; Humans ; Silicosis ; prevention & control ; South Africa

Carbon monoxide diffusing capacity(DLco) was evaluated before and after nifedipine administration in coal workers' pneumoconiosis by the size of radioopacity. Nifedipine was administered to 18 men and 17 men of small round opacity group and large opacity group respectively. Placebo was administered to 19 men and 15 men of small and large opacity group respectively. In large opacity group DLco was increased after nifedipine administration. But, it was not significant statistically(0.05 < p < 0.01). In other groups, there were no significance difference between and after medication.
Anthracosis* ; Carbon Monoxide ; Coal* ; Diffusion* ; Humans ; Male ; Nifedipine* ; Pneumoconiosis

This study was performed to investigate associations between serum alpha(1)-antitrypsin(AAT) concentration and radiological categories of coal workers' pneumoconlosis(CWP), between AAT concentration and pulmonary complications such as tuberculosis and emphysema, and to study associations between AAT concentration and FEV(1.0)% in CWP patients, We classified 254 CWP patients in D Hospital into categories of small opacity profusion. And we selected 86 subjects by with or without emphysematous finding in each categories by proportional stratified sampling method. Semm AAT concentrations were quantkated by single radial immunodiffusion method, and the findings of chest radiographs were evaluated by radilogist. The results were as follows: 1. Serum AAT concentrations were not significantly different among groups of radiological categories of small opacities. 2. Complication of emphysema was associated with smoking habits sigmficantlyl(chi square=12.16, p<0,01). And AAT concentraLion was higher in smokers and ex-smokers than in non-smokers. Serum AAT concentration was significantly higher in the cases with emphysema than in the cdses without emphybema{p<0.01). 3. Serum AAT concentration of the group with active pulmonary tuberculosis was significantly higher than with inactive or without: pulmonary tuberculosis group(p<0.1). 4. Serum AAT concentration of the group with low FEV(1.0)% was significantly higher than with high or normal group(p<0.05).
Anthracosis ; Coal* ; Emphysema ; Humans ; Immunodiffusion ; Pneumoconiosis* ; Radiography, Thoracic ; Smoke ; Smoking ; Tuberculosis ; Tuberculosis, Pulmonary

Antinuclear antibody(ANA) and rheumatoid factor(RF) in the sera of 191 coal workers pneumoconiosis(CWP) patients, 65 healthy coal workers, and 52 non-mining controls were examined by the categories of CWP, age, duration of exposure, smoking and drinking habit. Indirect fluorescent antibody technique for ANA and latex agglutination method for RF were applied for detection. ANA was positive in 24.3% of CWP patients, 10.8% of healthy coal workers and 11.5% of non-mining controls. RF was positive in 36.5 % of CWP patients, 13.8 % of healthy coal workers and 9.6 % of non-mining controls.
Agglutination ; Anthracosis* ; Antibodies, Antinuclear* ; Coal* ; Drinking ; Fluorescent Antibody Technique, Indirect ; Humans ; Latex ; Rheumatoid Factor* ; Smoke ; Smoking

OBJECTIVETo estimate the coverage level of case reporting for coal workers' pneumoconiosis (CWP) and the incidence of CWP in China according to the data from CWP reporting database in China as well as the data on annual raw coal output, coal workers, etc. from relevant year books, and to provide scientific data for CWP control measures.

METHODSThe data on the numbers of coal workers and annual raw coal outputs of national top 100 enterprises in coal sector (Top 100 in coal sector) were acquired from China Coal Industry Yearbook; the annual per capita output of raw coal in each enterprise was calculated. The numbers of coal workers in the enterprises other than the Top 100 were estimated based on the annual per capita output of raw coal in the Top 100 and the annual raw coal outputs of the enterprises other than the Top 100. The numbers of coal workers in the enterprises that reported CWP cases were estimated based on the distribution of these enterprises in China, and the coverage rates of case reporting in the Top 100 and other enterprises were calculated accordingly. The total number of CWP cases and the number of CWP cases due to per million tons of raw coal output were estimated according to the coverage rates of case reporting and the total numbers of reported CWP cases in China.

RESULTSThe mean coverage rates of case reporting in the Top 100 and other enterprises were 55.34% and 5.18%, respectively. The estimated mean numbers of new CWP cases in the Top 100 and other enterprises were 3088 and 98205, respectively; the estimated total number of new CWP cases nationwide was 101293. The estimated mean numbers of new CWP cases due to per million tons of raw coal output were 2.05 in the Top 100 and 7341 in other enterprises. The number of reported CWP cases accounted for 6.7% of the estimated number of CWP cases (6796/101293).

CONCLUSIONIt is urgent to enhance occupational disease control in coal sector, and the estimation results for CWP should be spread and applied. The system of occupational disease control should be further improved.

Anthracosis ; epidemiology ; China ; epidemiology ; Coal Mining ; Data Interpretation, Statistical ; Humans ; Incidence ; Male ; Occupational Exposure

OBJECTIVES: This study was performed in order to investigate the frequency of the TNF2 allele in patients with coal workers pneumoconiosis (CWP). METHODS: We compared the genotype distribution of TNFalpha gene promoter polymorphism between 80 CWP patients and 54 healthy controls. RESULTS: The results were as follows : 1. The rare allele TNF2 was significantly more frequent in CWP patients (20.6 %) than in controls (10.2 %). 2. The spontaneous or LPS-induced release of TNFalpha from the peripheral monocytes was slightly increased in the TNF2 group, but these values were not significantly different between groups. 3. In the CWP TNF2 group, the increase of LPS-induced TNFalpha release was significant in comparison with that of the controls. CONCLUSIONS: From the above results, we suggest that the TNF2 allele is strongly associated with susceptibility to CWP development.
Alleles ; Anthracosis ; Coal* ; Genotype ; Humans ; Monocytes ; Pneumoconiosis* ; Tumor Necrosis Factor-alpha*