OBJECTIVETo compare clinical therapeutic effects of acupuncture combined with magnetic therapy and simple magnetic therapy on temple-jaw joint dysfunction.

METHODSEighty-two cases were randomly divided into an observation group (n = 52) and a control group (n = 30). The observation group was treated with acupuncture at Xiaguan (ST 7), Jiache (ST 6), Hegu (LI 4), etc. and AL-2 low frequency electromagnetic comprehensive treatment instrument; the control group was treated with AL-2 low frequency electromagnetic comprehensive treatment instrument.

RESULTSThe cured and markedly effective rate of 90.4% in the observation group was significantly better than 66.7% in the control group (P < 0.01), and the total effective rate of 98.1% in the observation group was significantly better than 86.7% in the control group (P < 0.05).

CONCLUSIONThe therapeutic effect of acupuncture combined with magnetic therapy is significantly better than that of the simple magnetic therapy on temple-jaw joint dysfunction.

Acupuncture Points ; Acupuncture Therapy ; methods ; Adolescent ; Adult ; Aged ; Combined Modality Therapy ; Female ; Humans ; Magnetic Field Therapy ; instrumentation ; methods ; Male ; Middle Aged ; Temporomandibular Joint ; pathology ; Temporomandibular Joint Dysfunction Syndrome ; pathology ; therapy ; Treatment Outcome ; Young Adult

OBJECTIVETo evaluate the clinical effect of one stage anterior and posterior fusion and posterior fixation for the treatment of thoracic and lumbar spinal tuberculosis.

METHODSFrom March 2003 to December 2006, one stage anterior and posterior fusion and posterior fixation were performed to treat 23 patients who suffered thoracic and lumbar spinal tuberculosis. There were 15 males and 8 females with an average of 37.6 years (17-61 years). 4 cases' tuberculose focus were in thoracic vertebra, 8 cases in thoracolumbar, 11 cases in lumbar.

RESULTSThe average follow up period was 28.7 months (9-40 months). The symptoms of all patients had primarily relieved and the patients can ambulate at 2-3 weeks after treatment. At the 6th after operation, the X-ray showed interbody fusion. Frankel grading of 16 patients with incomplete paraplegia were improved averagely 1.62 grades. The major complications including 2 cases of temporary sinus formation, 1 case of fixtor breaking and 1 case of recurring (owing to an inadequate postoperative chemotherapy).

CONCLUSIONOne stage anterior and posterior fusion and posterior fixation can effectually resect focus, rebuild stability of spine, promote interbody fusion and recovery of incomplete paraplegia in treating thoracic and lumbar spinal tuberculosis.

Adolescent ; Adult ; Female ; Fracture Fixation, Internal ; Humans ; Lumbar Vertebrae ; surgery ; Male ; Middle Aged ; Postoperative Complications ; Spinal Fusion ; Thoracic Vertebrae ; surgery ; Treatment Outcome ; Tuberculosis, Spinal ; surgery ; Young Adult

OBJECTIVETo search for a better method for frozen shoulder due to cold damp.

METHODSSixty cases of frozen shoulder were randomly divided into an acupuncture-moxibustion group (32 cases) and an acupuncture group (28 cases). Acupuncture was applied mainly at Jianyu (LI 15), Jianliao (TE 14) and Jianzhen (SI 9) in either group. In acupuncture-moxibustion group, moxibustion on tender points was supplemented.

RESULTSIn acupuncture-moxibustion group, 7 cases were cured, 15 cases markedly effective, 9 cases improved and 1 case failed. The cured and markedly effective rate was 68.8% and the effective rate was 96.9%. In acupuncture group, 2 cases were cured, 9 cases markedly effective, 13 cases improved and 4 cases failed. The cured and markedly effective rate was 39.3% and the effective rate was 85.7%. The cured and markedly effective rate in acupuncture-moxibustion group was superior to that in acupuncture group (P < 0.05) and there was no significant difference in the effective rate statistically between two groups (P > 0.05).

CONCLUSIONThe clinical efficacy of acupuncture combined with moxibustion on tender points is superior to that of simple acupuncture on frozen shoulder due to cold damp.

Acupuncture Therapy ; methods ; Aged ; Bursitis ; therapy ; Cold Temperature ; Female ; Humans ; Male ; Medicine, Chinese Traditional ; Middle Aged ; Moxibustion ; methods

OBJECTIVETo explore the causes, prevention, and management of the complications during intracranial aneurysm embolization with controllable coils (mechanical detachable spiral, MDS; and Guglielmi detachable coil, GDC).

METHODSRetrospective review of 120 cases with 125 intracranial aneurysms embolized with controllable coils from March 1995 to July 1999 was conducted. The 20 accidents (in 18 cases) including aneurysm rupture, over-embolization, protrusion of coil end into the parent artery, and thrombosis of the parent artery were analyzed.

RESULTSAmong the 20 accidents, there were 6 aneurysm ruptures, 6 over-embolizations (in 5 cases), 6 coil protrusions, and 2 thromboses (one was secondary to coil protrusion). The embolization-related mortality was 3.33% (4/120), the permanent neurological deficit was 1.67% (2/120), and the transitory neurological deficit was 3.33% (4/120). The occurrence and outcome of the complications were related to the embolizing technique, the pattern of aneurysm and its parent artery, the imperfection of embolic materials, and the observation and management during embolization.

CONCLUSIONSkilled embolizing technique, better understanding of the angio-anatomy of an aneurysm and its parent artery, correct judgement and management during embolization, and improvement of embolic materials are beneficial to the reduction of complications and to the melioration of the outcome of complications.

Aneurysm, Ruptured ; etiology ; Embolization, Therapeutic ; adverse effects ; instrumentation ; Humans ; Intracranial Aneurysm ; therapy ; Retrospective Studies ; Thrombosis ; etiology

OBJECTIVETo compare the embolization effects of intracranial aneurysm with mechanical detachable spirals (MDS) and with Guglielmi detachable coils (GDC).

METHODSOne hundred and twenty cases with 125 intracranial aneurysms were embolized in Beijing Hospital from March 1995 to July 1999. Sixty-six aneurysms in 64 cases were embolised with MDS, 51 in 48 with GDC, and 8 in 8 with both MDS and GDC. Clinical data including sex, age, subarachnoid hemorrhage (SAH), Hunt & Hess grading, diameter and neck width of aneurysms, number and length of coils used per aneurysm, occlusive ratio, and complications were compared between MDS and GDC groups.

RESULTSMDS and GDC group were comparable (t-test or chi2-test, all P value > 0.10) in terms of age, sex, diameter of aneurysms [(8.46 +/- 3.42) mm vs. (7.38 +/- 3.45) mm], neck width [(3.49 +/- 1.50) mm vs. (3.26 +/- 1.52) mm], coils number [(4.65 +/- 3.01) vs. (4.24 +/- 2.65)] and their length [(460.2 +/- 398.5) mm vs. (422.9 +/- 387.1) mm] used per aneurysm, occlusive ratio in aneurysms embolized > or = 80% [(95.00% +/- 6.32%) vs. (94.19% +/- 7.63%)], mortality and permanent complications (7.8% vs. 4.2%).

CONCLUSIONSMDS and GDC are all materials for embolization of intracranial aneurysms. MDS is less expensive, but more difficult to control and of propensity to complications while GDC is more compliant, easier to be used, safer, and have many alternative types for use as well a more extensive indications.

Adult ; Aged ; Aged, 80 and over ; Embolization, Therapeutic ; instrumentation ; methods ; Female ; Follow-Up Studies ; Humans ; Intracranial Aneurysm ; therapy ; Male ; Middle Aged ; Postoperative Complications ; Retrospective Studies ; Treatment Outcome

OBJECTIVE: To carry out prenatal genetic testing for a fetus with de novo 46,X,der(X)t(X;Y)(q26;q11). METHODS: A pregnant woman who had visited the Birth Health Clinic of Lianyungang Maternal and Child Health Care Hospital on May 22, 2021 was selected as the study subject. Clinical data of the woman was collected. Peripheral blood samples of the woman and her husband and umbilical cord blood of the fetus were collected and subjected to conventional G-banded chromosomal karyotyping analysis. Fetal DNA was also extracted from amniotic fluid sample and subjected to chromosomal microarray analysis (CMA). RESULTS: For the pregnant women, ultrasonography at 25th gestational week had revealed permanent left superior vena cava and mild mitral and tricuspid regurgitation. G-banded karyotyping analysis showed that the pter-q11 segment of the fetal Y chromosome was connected to the Xq26 of the X chromosome, suggesting a Xq-Yq reciprocal translocation. No obvious chromosomal abnormality was found in the pregnant woman and her husband. The CMA results showed that there was approximately 21 Mb loss of heterozygosity at the end of the long arm of the fetal X chromosome [arr [hg19] Xq26.3q28(133912218_154941869)×1], and 42 Mb duplication at the end of the long arm of the Y chromosome [arr [hg19] Yq11.221qter(17405918_59032809)×1]. Combined with the search results of DGV, OMIM, DECIPHER, ClinGen and PubMed databases, and based on the guidelines from the American College of Medical Genetics and Genomics (ACMG), the deletion of arr[hg19] Xq26.3q28(133912218_154941869)×1 region was rated as pathogenic, and the duplication of arr[hg19] Yq11.221qter(17405918_59032809)×1 region was rated as variant of uncertain significance. CONCLUSION The Xq-Yq reciprocal translocation probably underlay the ultrasonographic anomalies in this fetus, and may lead to premature ovarian insufficiency and developmental delay after birth. Combined G-banded karyotyping analysis and CMA can determine the type and origin of fetal chromosomal structural abnormalities as well as distinguish balanced and unbalanced translocations, which has important reference value for the ongoing pregnancy.
Humans ; Child ; Pregnancy ; Female ; Vena Cava, Superior ; In Situ Hybridization, Fluorescence ; Chromosome Aberrations ; Karyotyping ; Translocation, Genetic ; Fetus ; Prenatal Diagnosis/methods*

Objective　To explore the creation of intracranial arteriovenous malformation (AVM) animal model and its application in embolization. Methods　Using their rete mirabile (ReM) as nidus of AVM, we selected nine Chinese Experimental Mini-pigs (CEMPs) to create AVM animal models mainly by right carotid-jugular anastomosis (CJA) and ligation of the right external carotid artery. The models were embolized respectively with n-butal 2-cyanoacrylate and embosphere, and the ReM, CJA vessel and brain of the animal were removed for histopathological observation. Angiographies were arranged before and after model creation as well as pre- and post embolization. Combined with angio-images and histopathological findings, the applications of the model, the reason of CJA stoma occlusion, and the possibility of model improvement were discussed. Results　The AVM animal model was successfully created in seven 　CEMPs, which was similar to 　human brain 　AVM in angio-architecture, angiographic-image, embolizing behavior and post embolization pathological findings. Thromboses were found inside the CJA vessels in 4 animals and in the rest 3 the CJA vessels were shrunk without thrombus. The brain histopathological changes of the dead animal after embolization were of ischemic infarction. Conclusions　Although our method is relatively more simple and rather reliable, which is suitable for the embolizing research of embolic agents and for the training of interventional staff, it reaches however an acute (short-term) model and its applications are evidently limit. How to prevent the CJA stoma occlusion and to let animal tolerate the embolization need further studies.

Objective　To explore the creation of intracranial arteriovenous malformation (AVM) animal model and its application in embolization. Methods　Using their rete mirabile (ReM) as nidus of AVM, we selected nine Chinese Experimental Mini-pigs (CEMPs) to create AVM animal models mainly by right carotid-jugular anastomosis (CJA) and ligation of the right external carotid artery. The models were embolized respectively with n-butal 2-cyanoacrylate and embosphere, and the ReM, CJA vessel and brain of the animal were removed for histopathological observation. Angiographies were arranged before and after model creation as well as pre- and post embolization. Combined with angio-images and histopathological findings, the applications of the model, the reason of CJA stoma occlusion, and the possibility of model improvement were discussed. Results　The AVM animal model was successfully created in seven 　CEMPs, which was similar to 　human brain 　AVM in angio-architecture, angiographic-image, embolizing behavior and post embolization pathological findings. Thromboses were found inside the CJA vessels in 4 animals and in the rest 3 the CJA vessels were shrunk without thrombus. The brain histopathological changes of the dead animal after embolization were of ischemic infarction. Conclusions　Although our method is relatively more simple and rather reliable, which is suitable for the embolizing research of embolic agents and for the training of interventional staff, it reaches however an acute (short-term) model and its applications are evidently limit. How to prevent the CJA stoma occlusion and to let animal tolerate the embolization need further studies.

OBJECTIVE: To explore the clinical and genetic features of an adult female with premature ovarian failure (POF) and mosaic ring chromosome 13. METHODS: The patient was subjected to G-banding karyotyping and chromosomal microarray analysis (CMA). RESULTS: The patient was diagnosed as POF and had a karyotype of 46,XX,r(13)(p13q34)[86]/45,XX,-13[9]/46,XX,r(13;13)[5]. CMA analysis has failed to detect any deletion in the long arm of chromosome 13. Literature review suggested that the ring chromosome 13 may have clinical symptoms similar to those of sex chromosome abnormalities. CONCLUSION A case of mosaic ring chromosome 13 and POF has been reported. Mosaic ring chromosome 13 may lead to symptoms of POF similar to sex chromosomal abnormalities.
Adult ; Chromosome Aberrations ; Female ; Humans ; Karyotype ; Karyotyping ; Phenotype ; Primary Ovarian Insufficiency ; genetics

ObjectiveTo observe and compare the intervention effect of modified Cangfu Daotantang on glucose and lipid metabolism in simple obese children with phlegm dampness and stagnation. MethodA total of 60 children with simple obesity were randomly divided into two groups according to the simple randomization method of the random number table. The odd number was included in the test group， and the even number was included in the basic treatment group， with 30 cases in each group. On the basis of signing the informed consent notice， the treatment group was given modified Cangfu Daotantang combined with basic treatment， while the control group was only given basic treatment. After three months of treatment， the body mass index （BMI）， glucose and lipid metabolism level ［total cholesterol （TC）， triglyceride （TG）， low-density lipoprotein cholesterol （LDL-C）， fasting plasma glucose （FPG）， fasting insulin （FINS）， and homeostasis model assessment-insulin resistance （HOMA-IR）］， the change in the total score of traditional Chinese medicine （TCM） syndromes， and the effective rate of treatment were observed and compared. ResultAfter treatment， the BMI of the observation group and the control group decreased significantly （P<0.01）. Compared with the control group， the BMI level in the observation group decreased significantly （P<0.05）. After treatment， the levels of TC， TG， and LDL-C in the observation group and the control group decreased significantly （P<0.01）. Compared with the control group， the levels of TC， TG， and LDL-C in the observation group decreased significantly （P<0.05）. In addition， the level of TC in the observation group improved significantly compared with that in the control group （P<0.01）. The levels of FPG， FINS， and HOMA-IR in the observation group and the control group were significantly lower than those before treatment （P<0.05）. After treatment， compared with the control group， the levels of FPG， FINS， and HOMA-IR in the observation group were significantly reduced （P<0.05）. The level of FPG in the observation group was significantly improved compared with that in the control group （P<0.01）. After treatment， the total score of TCM syndromes in the two groups decreased significantly （P<0.01）. Compared with the control group， the total score of TCM syndromes in the observation group was lower （P<0.01）. After treatment， the total effective rate of treatment was 86.67% （26/30） in the observation group and 73.33% （22/30） in the control group. By rank sum test， the total effective rate of the observation group was better than that of the control group （Z=-2.100， P<0.05）. ConclusionModified Cangfu Daotantang combined with basic treatment can effectively reduce the BMI of obese children and improve their glucose and lipid metabolism. It has good clinical effects and high clinical application value， which is worth further in-depth research and promotion.