No abstract available.
Anomia* ; Cognition Disorders* ; Hypoglycemia

BACKGROUND: Impairments of language function represent patients with Alzheimer's disease (AD) from the early stage and as the disease progresses the damage spreads over a much broader range of cognition and communicative functions. And, performances of the naming tasks in AD patients may reveal the gradual deterioration of their naming ability. METHODS: In this study, naming ability was studied in patients with questionable AD (CDR 0.5, n=10), mild AD (CDR 1, n=10), moderate AD (CDR 2, n=10) and 10 healthy controls matched for age, gender and educational level using confrontation naming and naming by verbal definition tasks. The purpose of present study was 1) to investigate whether the confrontation naming and naming by verbal definition in Alzheimer's disease is different depending on the severity, 2) to examine the effects of the syllabic cue on the two naming ability for the errors questions. RESULTS: The results from this study are as follow: 1) The two naming performances of the all AD groups were lower than those of normal people and showed significant difference. 2) There were differences between the two naming tasks, significantly lower performance on confrontation naming task than naming by verbal definition. 3) The effects of syllabic cue decreased gradually as severity progressed. 4) The effects of syllabic cue were no significant differences between the two naming tasks. CONCLUSIONS: The results suggest that anomia in patients with AD is due to various impairment including to lexico-semantic system, visual processing, phonological processing and auditory comprehension.
Alzheimer Disease ; Anomia ; Cognition ; Comprehension ; Cues ; Humans

Anomia is the most common sign observed in aphasic patients. However, patients showing only pure anomia, caused by brain lesions were rare. We report a case of an acute stroke patient with isolated pure anomia from the lesion of superior and middle temporal gyrus. We confirmed naming impairment with relatively intact comprehension, fluency and repetition through the Korean version Western Aphasia Battery. We speculate that the superior and middle temporal area should be associated with the ability of semantics to access the phonological lexicon.
Anomia* ; Aphasia ; Brain ; Comprehension ; Humans ; Infarction* ; Semantics ; Stroke ; Temporal Lobe*

The authors describe a case of accidental eletrical injury from high voltage direct current in a young worker, who was struck by the electric shock in the left occipito-parietal region. This case is interesting due to the development of left ooccipito-parietal parenchymal brain lesion with transient anomic aphasia and visual disturbances. We believe that is first report on parenchymal brain injury due to high voltage electrical burn confirmed pathologically in Korea. The patient had full thickness scalp defect, skull necrosis, and parenchymal brain injury. We performed one stage brain and dural biopsy with split rib graft cranioplasty after removal of devitalized skull and scalp flap surgery. The clinical presentation, radiological, pathological finding, and outcome are reviewed.
Anomia ; Biopsy ; Brain Injuries ; Brain* ; Burns* ; Humans ; Korea ; Necrosis ; Ribs ; Scalp* ; Shock ; Skull* ; Transplants

Optic aphasia is a rare syndrome in which patients are unable to name visually presented objects but have no difficulty in naming those objects on tactile or verbal presentation. We report a 79-year-old man who exhibited anomic aphasia after a left posterior cerebral artery territory infarction. His naming ability was intact on tactile and verbal semantic presentation. The results of the systematic assessment of visual processing of objects and letters indicated that he had optic aphasia with mixed features of visual associative agnosia. Interestingly, although he had difficulty reading Hanja (an ideogram), he could point to Hanja letters on verbal description of their meaning, suggesting that the processes of recognizing objects and Hanja share a common mechanism.
Aged ; Agnosia ; Anomia ; Aphasia* ; Dyslexia ; Humans ; Infarction ; Posterior Cerebral Artery ; Semantics

OBJECTIVE: The purpose of this study is to evaluate the types of aphasia and the clinicoanatomic correlation in aphasic patients with subcortical lesions, and to investigate the change in the types of aphasia during the recovery stage. METHOD: Twenty-three stroke patients (16 men and 7 women) with left subcortical lesion was investigated. On the basis of the brain CT or MRI findings, the patients were divided into the 4 groups. Language dysfuntion was evaluated using the modified Western Aphasia Battery (WAB) and the type of aphasia and aphasia quotient were determined. Initial examination was performed within 2 months post-onset in all of the patients and the follow-up examination was done after 6 months post-onset in 9 patients. RESULTS: The most common type was anomic aphasia (39%). The type of subcortical aphasia was variable regardless of the sites of left subcortical lesion. Aphasia quotient was significantly related with the lesion size (gamma = 0.05, p<0.05) and the initial Barthel index (gamma = 0.65, p<0.05). The scores of all the subtests of the modified WAB and aphasia quotient were significantly decreased in the group with the cortical involvement or the history of operation. On the follow-up examination, the scores of fluency, information and naming subtests were significantly increased. CONCLUSION: The most common type of aphasia was anomic aphasia and the type of subcortical aphasia was not correlated to the anatomic lesion. Severity of subcortical aphasia would be related with the lesion size, the history of operation or the cortical involvement. The prognosis of subcortical aphasia was generally good.
Anomia ; Aphasia* ; Brain ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging ; Male ; Prognosis ; Stroke

OBJECTIVE: To evaluate the types and severity of subcortical aphasia after stroke and to determine the predictors of the degree of aphasic impairment. METHODS: Medical records of 38 patients with post-stroke subcortical aphasia (19 males; mean age, 61.7±13.8 years) were reviewed retrospectively with respect to the following tests: the Korean version of the Western Aphasia Battery (K-WAB), the Korean version of the Modified Barthel Index (K-MBI), and the Fugl-Meyer Index (FMI). The severity of aphasia was evaluated by the aphasia quotient (AQ) and the language quotient (LQ). RESULTS: Anomic aphasia was the most frequent type of aphasia (n=15, 39.5%), and the lesion most frequently observed in subcortical aphasia was located in the basal ganglia (n=19, 50.0%). Patients with lesions in the basal ganglia exhibited the lowest scores on the FMI for the upper extremities (p=0.04). Severity of aphasia was significantly correlated with the K-MBI (Pearson correlation coefficient: γ=0.45, p=0.01 for AQ and γ=0.53, p=0.01 for LQ) and FMI scores for the lower extremities (γ=0.43, p=0.03 for AQ and γ=0.49, p=0.05 for LQ). In a multivariate logistic regression analysis, K-MBI remained the only explanatory variable closely associated with aphasia severity. CONCLUSION: This study showed the general characteristics of post-stroke subcortical aphasia, and it revealed that K-MBI was an associated and explanatory factor for aphasia severity.
Anomia ; Aphasia* ; Basal Ganglia ; Cerebrovascular Disorders ; Humans ; Language Tests ; Logistic Models ; Lower Extremity ; Male ; Medical Records ; Retrospective Studies ; Stroke* ; Upper Extremity

It has been known that right ACA occlusions can cause callosal disconnection syndrome. A 61-year old right-handed man was admitted because of a left ACA occlusion. MRI showed infarction of the medial frontal cortex and the anterior two-thirds of the corpus callosum. He presented with weakness and gait initiation failure in the right leg with grasp reflex, suspicious alien hand sign, and tactile anomia in the right hand. He was diagnosed with transcortical motor aphasia. He was unable to successfully complete written tasks in response to dictations and writing down spontaneous answers. He wrote down incorrect words and demonstrated paragraphism with his left hand. He could copy simple items but not written words and complex items with his left hand. Finally, he had difficulties in writing answers in response to complex verbal and written commands with his left hand, but preserved the ability to simple verbal commands, somato-sensory, and visually guided tasks. We attribute these results to the anterior callosal disconnection of the right sensorimotor cortex from the left language area.
Anomia ; Anterior Cerebral Artery ; Aphasia, Broca ; Corpus Callosum ; Emigrants and Immigrants ; Gait ; Hand ; Hand Strength ; Humans ; Infarction ; Leg ; Magnetic Resonance Imaging ; Middle Aged ; Reflex ; Writing

BACKGROUND: The thalamus has multiple connections with areas of the cerebral cortex involved in arousal and cognition. Thalamic damage has been reported to be associated with variable neuropsychological dysfunctions and dementia. This study investigates the changes of regional cerebral blood flow (rCBF) by using SPM analysis of 99mTc-ECD SPECT and examining the neuropsychological abnormalities of 4 patients with anterior thalamic infarctions. METHODS: Four patients with left anterior thalamic infarctions and eleven normal controls were evaluated. K-MMSE and the Seoul Neuropsychological Screening Battery were performed within 2 days after stroke. The normalized SPECT data of 4 patients were compared to those of 11 controls for the detection of areas with decreased rCBF by SPM analysis. RESULTS: All 4 patients showed anterograde amnesia in their verbal memory, which was not improved by recognition. Dysexecutive features were occasionally present, such as decreased word fluency and impaired Stroop test results. SPM analysis revealed decreased rCBF in the left supramarginal gyrus, the superior temporal gyrus, the middle and inferior frontal gyrus, the medial dorsal and anterior nucleus of the left thalamus. CONCLUSIONS: The changes of rCBF in patients with left anterior thalamic infarctions may be due to the remote suppression on metabolism by the interruption of the cortico-subcortial circuit, which connects the anterior thalamic nucleus and various cortical areas. The executive dysfunction and dysnomia may be caused by the left dorsolateral frontal dysfunction of the thalamocortical circuit. Anterograde amnesia with storage deficit may be caused by the disruption of mamillothalamic tract.
Amnesia, Anterograde ; Anomia ; Arousal ; Cerebral Cortex ; Cognition ; Dementia ; Humans ; Infarction* ; Mass Screening ; Memory ; Metabolism ; Seoul ; Stroke ; Stroop Test ; Thalamus ; Tomography, Emission-Computed, Single-Photon*

BACKGROUND & SIGNIFICANCE: Progressive multifocal leukoencephalopathy(PML), a rare neurologic disease caused by papovavirus, has been sporadically reported with defective cell-mediated immunity. We report one case of pathologically proven PML complicating chronic myelocytic leukemia(CML). CASE: The patient was a 42-year-old women, who had been diagnosed as CML at age 32 and received autologous bone marrow transplantation 16 months before. She admitted because of progressive memory disturbance and anomic aphasia over several months. Neuropsychological test suggested a left temporal lobe lesion. On T2-weighted brain MR image, there was a diffuse high signal intensity lesion in the left temporal lobe with some mottled enhancement and also in the left corona radiata and deep frontal area. Brain biopsy was done and the JC strain of papovairus was detected by in-situ hybridization technique. Cytarabine, alphainterferon, and acyclovir were tried. About 2 weeks after the medications, significant clinical improvement was noticed. A follow-up MRI 2 month and 6 months later revealed a significant reduction in the extent of the lesion. CONCLUSION: This is the firsts reported case of pathologically-proven PML in Korea. Unlike the usual PML described in the literature, our patient have showed clinical and radiological improvement in the course of illness.
Acyclovir ; Adult ; Anomia ; Biopsy ; Bone Marrow Transplantation ; Brain ; Cytarabine ; Female ; Follow-Up Studies ; Humans ; Immunity, Cellular ; Korea ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive* ; Leukoencephalopathy, Progressive Multifocal* ; Magnetic Resonance Imaging ; Memory ; Neuropsychological Tests ; Temporal Lobe