Objective:To determine the content of chloroform, ethyl acetate and DMF in dimemorfan phosphate by gas chromatog-raphy (GC). Methods:The capillary gas chromatography was used with a PEG-20M column, programmed temperature, water as the solvent and FID as the detector. Results:The three organic solvents were separated and showed good linear relationship (r>0. 999 0). The detection limit of chloroform, ethyl acetate and DMF was 0. 63,0. 60 and 8. 92μg·ml-1 , respectively. The residues of the organ-ic solvents in three batches of the samples all met with the requirements of ICH. Conclusion: The method is sensitive, accurate and reliable, and can be used in the quality control of dimemorfan phosphate.

Obstructive sleep apnea (OSA) is the most common sleep-disordered breathing disease, with high incidence and serious harm. Polysomnography (PSG) is currently the "gold standard" for the diagnosis of OSA, but its clinical application in pregnant population is restricted in many ways, so the preliminary sleep screening scale has become an effective choice for evaluating and predicting the occurrence of OSA in pregnant people. Therefore, this paper reviews the current status of application of related sleep preliminary screening scales in pregnant population so as to clarify the screening value of every scale and provide references for future clinical research.

Objective To establish a gas chromatograph method for determing Chloroform, ethyl acetate and N, N-dimethyl formamide in butoconazole nitrate. Methods The samples was detected by Headspace Gas Chromatography. Temperature programming method was adpoted and FID was used as detector. The injector temperature was 200 ℃, and the detector temperature was reach 250 ℃. Nitrogen was used as carrier gas in the experiment. Results In the mentioned chromatographic conditions, Chloroform, ethyl acetate and N, N-dimethyl formamide had good linear relationships in the ranges of 0. 066-0. 588,0. 062-0. 556 and 0. 896-8. 061 μg·mL-1 respectively. The average recoveries were 99. 18%,102. 84% and 98. 71%. RSD were 3. 87%,4. 33% and 3. 71%. Conclusion The detection method is sensitive, accurate, reliable, and can be used as a quality control for butoconazole nitrate.

Objective:To establish a method for the determination of dichloromethane, methanol and ethanol in fenticonazole ni-trate. Methods:The samples were detected by headspace GC. The column was OV-1301(30 m × 0. 53 mm,3. 0 μm), the detector was FID with nitrogen as the carrier gas, the detector temperature was 250 ℃ and the injector temperature was 200 ℃. Results:The linear range of dichloromethane, methanol and ethanol was 2. 436-21. 924(r=0. 998 8), 12. 268-110. 412(r=0. 999 5) and 20. 052-180. 468 μg·ml-1(r=0. 996 9) with the average recovery of 99. 30% (RSD=2. 36%), 100. 21%(RSD=1. 07%) and 100. 15%(RSD=1. 21%)(n=9), respectively. Conclusion:The detection method is sensitive, accurate and reliable, and can be used in the quality control of fenticonazole nitrate.

Objective:To explore the influencing factors of low carbohydrate diet (LCD) management compliance in patients with type 2 diabetes mellitus (T2DM) so as to provide a basis for improving diet compliance of patients.Methods:From May to September 2019, we selected 16 T2DM patients participating in LCD project for three months in Department of Endocrinology of the Second Affiliated Hospital of Soochow University as interviewees by purposive sampling. The semi-structured interview was carried out for them, and Colaizzi analysis was used to interview data sorting and analysis.Results:A total of two themes were extracted, the promoting factors and obstructing factors. The promoting factors included the perceived benefits, positive psychological effect, multiplex social support, strengthening diet and blood glucose management as well as operational diet plan; the obstructing factors involved the perceived no benefits, difference between diet knowledge and actual demand, diet habit facing a challenge, increasing social role stress, difficulty carrying out diet plan.Conclusions:LCD management compliance of T2DM patients have many influencing factors. Patients, family members and medical staff should be paid attention to integrated management of LCD for diabetic patients in future.

Objective To study the status of filial piety and anxiety among adults, explore the relationship between filial piety and anxiety, and analyze the factors that affect anxiety. Methods A total of 915 adults from Jiangsu and Anhui provinces were selected using the General Information Questionnaire, the Chinese Filial Values Index scale (FVI) and Zung Self-rating Anxiety Scale (SAS), through the online platform and on-site payment, recovery of the questionnaire to investigate. Results The overall level of filial piety was 85.23 ± 9.22 , among which the care dimension was 84.60 ± 9.75 and the respect dimension was 86.12 ± 11.76;111 adults were with anxiety (12.13％), and patients with mild and moderate anxiety respectively were 88 (9.62％) and 23 (2.51％) cases. The overall level of filial piety was negatively correlated with the level of anxiety (r=-0.403, P<0.01), and the level of filial piety is an independent factor affecting the level of anxiety in adults(B=-0.299,P<0.01). Other factors also include the quality of sleep, illness, duration, beliefs, occupational stability. Conclusion The high level of filial piety in adults is moderately correlated with anxiety and is an independent risk factor for anxiety in this population. The adult's education of filial piety should be strengthened and the positive adjustment of filial piety to anxiety should be strengthened in order to better solve the physical and mental health problems caused by the pension burden.

Objective? To investigate the status of filial piety values and care-giving burden of caregivers of patients with chronic heart failure(CHF) and to explore the influence of filial piety values on care-giving burden. Methods? By purposive sampling method, 190 CHF patients and their caregivers were selected from three hospitals in Nanjing, Kunshan and Suzhou from April 2017 to April 2018. Patients' General Information Questionnaire, caregivers' General Information Questionnaire, Chinese version of Filial Values Index(FVI), and Dutch Objective Burden Inventory(DOBI) for chronic heart failure patients' caregivers were used in the study. Results? The total scores of FVI and DOBI of caregivers of CHF patients were (94.88±11.29) and (7.01±11.25). Patient's course of disease, caregiver's gender, whether to live with patients, attitude to patients' disease and filial piety were the influencing factors of care burden (P＜ 0.05). Conclusions? It is suggested that more attention should be paid to the burden of caregivers of patients with chronic heart failure and interventions should be taken to improve their filial piety values so as to reduce their burden of care.

Objective To investigate the prevalence and specific manifestations of enduring psychological distress in patients with breast cancer after operation. Methods Totally 263 patients of the newly diagnosed breast cancer treated with the operation from August 2014 to August 2015 were collected by convenience sampling. Distress Thermometer (DT) and Problem List recommended by national Comprehensive Cancer Network was used to assess the persistent psychological distresses in the 6th, 15th, 20th, 25th, 30th months after the disease diagnosis,while a self-designed questionnaire was for the demographic data. Results The results of the DT screening showed that 16％(42/263) patients had persistent psychological problems;the incidences of five stages of significant psychological distress (DT≥4) was 43％(113/263), 34％(89/263), 31％(81/263), 28％ (73/263) and 25％ (65/263), respectively. The main manifestations of persistent psychological distress were:fatigue 59 cases (22.4％) , sleep disorders 51 cases (19.4％), nervous 48 cases (18.2％), anxiety 24 cases (9.1％), fear of appearance 23 cases (8.7％) and the difference in persistent psychological distress scores between different demographic characteristics (age, educational level, marital status, economic situation, operation method, disease stage) were statistically significant (t=-2.295-2.966, P<0.05). Conclusion The incidences of persistent psychological distress in patients with breast cancer is higher and the manifestation is different,which should be paid attention to by medical workers.

Objective:To investigate the latent classes and influencing factors of vicarious posttraumatic growth among emergency nurses.Methods:Convenience sampling method was used to select the 498 emergency nurses of 20 public general hospitals in Anhui province as the survey objects. The general information questionnaire and Posttraumatic Growth Inventory were used to investigate. Latent class analysis was used to classify vicarious posttraumatic growth of emergency nurses, and the influencing factors of latent classes were analyzed by binary logistic regression.Results:There were two latent classes of vicarious posttraumatic growth of emergency nurses including high growth-high fluctuation group (24.1%, 120/498) and low growth group (75.9%, 378/498). Binary logistic regression analysis showed that professional title, average monthly income and self-rated health status were the factors influencing the latent classes (all P<0.05). Conclusions:There are obvious classification characteristics of vicarious posttraumatic growth among emergency nurses. Nursing managers should formulate and implement targeted intervention measures according to the classification characteristics and influencing factors to improve their vicarious posttraumatic growth level.

Diet therapy is the cornerstone of the treatment for type 2 diabetes. Different dietary patterns have certain effects on improving blood glucose and lipid metabolism in patients with type 2 diabetes, but they also have certain limitations. This article mainly reviews the current status of dietary treatment for patients with type 2 diabetes and the influence of common diet patterns on metabolism, so as to provide a reference for patients with type 2 diabetes to choose an appropriate diet pattern.