Liposarcoma is a rare mesenchymal tumor that occurs most commonly in the soft tissue of the extremities. It develops deeply in the intramuscular fatty tissue and consists of lipoblasts. We experienced a case of well-differentiated liposarcoma on the thigh of a 48-year-old female, who presented with a skin-colored, child fist-sized mass. Liposarcoma is rare in the dermatologic field, so we herein report a case of well-differentiated liposarcoma.
Adipose Tissue ; Child ; Extremities ; Female ; Humans ; Liposarcoma* ; Middle Aged ; Thigh

Basal cell carcinoma is the most common cancer in humans. It appears most frequently in areas of the body routinely exposed to light. Basal cell carcinoma which is entirely or partially located on the areolar-nipple complex is a rare phenomenon. We report a case of basal cell carcinoma of the areolar-nipple complex in a 73-year-old man.
Aged ; Carcinoma, Basal Cell* ; Humans ; Nipples*

Basal cell carcinoma (BCC) is the most common malignant skin cancer, consisting of 70-75% of all malignant tumors of the skin. Nevertheless, BCC located on the scrotum is exceedingly rare. Exposure to ultraviolet light (UV) is the most frequent factor predisposing to the development of BCC. However, with BCC of the scrotum, the etiology remains unclear. We report a case of basal cell carcinoma of the scrotum in a 68-year-old male patient, a review of the literature.
Aged ; Carcinoma, Basal Cell* ; Genitalia ; Humans ; Male ; Scrotum* ; Skin ; Skin Neoplasms ; Ultraviolet Rays

We report here on a case of secondary cutaneous diffuse large B-cell lymphoma (DLBCL) that occurred in a 67-year-old man who had a 2-month history of nodular growing masses on the left cheek, plus palpable lymph nodes on the left cervical area. The histopathological findings showed a diffuse infiltration of large atypical lymphocytes with nuclear atypia throughout the entire dermis. These showed positive CD20, bcl-2 and the post-germinal center marker, MUM-1. According to the WHO (World Health Organization) classification, this lymphoma is considered to be diffuse large B-cell lymphoma of the post-germinal center (GC) B-cell type with a secondary cutaneous manifestation. We treated the patient with systemic chemotherapy (CHOP) and anti-CD20 monoclonal antibodies. During the course of treatment, new skin lesions developed on his neck, so we changed the regimen to cytosin- arabinoside and cisplatin. But he died of pneumonia after the third cycle.
Aged ; Antibodies, Monoclonal ; B-Lymphocytes* ; Cheek ; Cisplatin ; Classification ; Dermis ; Drug Therapy ; Humans ; Lymph Nodes ; Lymphocytes ; Lymphoma ; Lymphoma, B-Cell* ; Neck ; Pneumonia ; Skin ; World Health Organization

Aleukemic leukemia cutis is a rare condition characterized by invasion of leukemic cells in the skin before their appearance in the peripheral blood or bone marrow. We report a case of a 24-year-old man who presented with a 2-month history of nodules on his chin and left thigh. His medical history included acute myelocytic leukemia which had been in complete remission for 13 years and seminoma of the right testis which had been treated with orchiectomy 1 year before. Biopsy of the cutaneous lesions revealed infiltrating cells characterized by irregular shaped or kidney bean-shaped nuclei with abundant pale, slightly eosinophilic cytoplasm. These atypical cells stained positive for leukocyte common antigen, lysozyme and myeloperoxidase. His peripheral blood examination and bone marrow biopsy failed to demonstrate leukemic changes. With these results, a diagnosis of aleukemic leukemia cutis was made. We then performed another immunohistochemical stain for lysozyme and myeloperoxidase on the testicular specimen which had been diagnosed as seminoma 1 year previously. The tumor cells of seminoma were lysozyme- and myeloperoxidase-positive. We were also able to diagnose seminoma as isolated granulocytic sarcoma. A complete remission of the cutaneous lesion was achieved with chemotherapy, but recurrent leukemia cutis reappeared six months later. He underwent a bone marrow transplant but died 3 months later.
Antigens, CD45 ; Biopsy ; Bone Marrow ; Chin ; Cytoplasm ; Diagnosis ; Drug Therapy ; Eosinophils ; Humans ; Kidney ; Leukemia* ; Leukemia, Myeloid, Acute ; Muramidase ; Orchiectomy ; Peroxidase ; Sarcoma, Myeloid ; Seminoma ; Skin ; Testis ; Thigh ; Young Adult

Xanthomas have been shown to occur in association with underlying lymphoproliferative disease, and sometimes are the result of lipid deposition in damaged or altered skin. Here in, we describe a case of eruptive xanthomas which developed in a patient suffering from mycosis fungoides. A 45-year-old Korean man presented for the evaluation of patches on the glans of his penis and on pretibial areas, which had persisted for a period of 3 years. Three months before the patient's admission, erythematous papules had developed on his trunk and extremities. Biopsies of lesions which had manifested as patches on the patient's pretibial areas and as papules on his right arm showed dermal infiltration of atypical lymphocytes, with epidermotropism and a diffuse infiltration of lipid-laden foamy cells. The histological findings were determined to be consistent with both mycosis fungoides and xanthoma.
Arm ; Biopsy ; Extremities ; Humans ; Lymphocytes ; Male ; Middle Aged ; Mycosis Fungoides* ; Penis ; Skin ; Xanthomatosis*

Congenital neurofibromatosis type 1, or Von Recklinghausen's disease is an autosomal dominant disorder characterized by neurofibroma, pigmented skin lesions (Cafe-au-lait macules), iris hamartomas and meningeal tumors, but rarely, by autonomic ganglia tumors, such as pheochromocytomas. We have experienced an intrathoracic and chest wall plexiform neurofibroma intimately contacted with collagenoma-like, dome-shaped skin lesions of type 1 neurofibromatosis, which are relatively rare and interesting, but can be regarded as typical findings in neurofibromatosis. Although intrathoracic neurogenic tumors are not uncommon, cases like ours are interesting, as the feature of collagenoma-like skin neurofibroma was very closely apposited with chest wall neurofibroma. Our case had no aypical features of malignancy and the patient was clinically followed up without recurrence.
Ganglia, Autonomic ; Hamartoma ; Humans ; Iris ; Meningeal Neoplasms ; Neurofibroma* ; Neurofibroma, Plexiform* ; Neurofibromatoses ; Neurofibromatosis 1* ; Pheochromocytoma ; Recurrence ; Skin ; Thoracic Wall* ; Thorax*

A 59-year old man presented with a 0.5 x 0.3 cm-sized area of, pink-colored, dome-shaped papules on the paranasal area. There was no previous history of trauma to the area. Histopathologic diagnosis was consistent with eccrine poroma. We reported a case of eccrine poroma arising on the paranasal area, an unusual location for this condition.
Diagnosis ; Humans ; Middle Aged ; Poroma*

The pathology related to a tick bite reaction is well described. Formation of a cavity below the mouthparts of the tick and mixed dense cellular dermal infiltration are general histopathologic findings of a tick bite. In addition, granuloma formation, vasculitic response, and panniculitis were reported. We present two cases of tick bite showing a new histopathologic finding, a localized fat herniation response.
Granuloma ; Panniculitis ; Pathology ; Tick Bites* ; Ticks*

The keratinocytes in human epidermis are replaced by a population of stem cells located in the basal layer of the epidermis and one candidate stem cell marker is the transcription factor p63. We studied the expression of p63, immunohistochemically, in various hyperproliferative skin diseases (10 poorly differentiated metastatis squamous cell carcinomas (SCCs), 10 non-metastatic primary cutaneous SCCs, 10 cases of Bowen's diseases, 10 actinic keratosis, and 10 melanomas) and also observed the change of p63 expression in psoriasis after cyclosporine treatment. p63 was normally expressed in basal layer cells. Poorly-differentiated metastatic SCC showed the highest expression in most of the tumor cells, while psoriasis, actinic keratosis, Bowen's disease and primary SCC showed an increased expression in the basal and suprabasal area compared to in normal epidermis. The cyclosporine treatment in psoriasis reduced the expression of p63 to a normal level. This data suggests that p63 expression may influence tumor cell differentiation and proliferation without a direct tumorigenesis effect in epithelial tissue.
Bowen's Disease ; Carcinogenesis ; Carcinoma, Squamous Cell ; Cell Differentiation ; Cyclosporine ; Epidermis ; Humans ; Keratinocytes ; Keratosis, Actinic ; Psoriasis ; Skin Diseases* ; Skin* ; Stem Cells ; Transcription Factors