Objective: To observe the effect of cancer nursing plan based on risk concept on complications, self-care ability and quality of life of patients with cervical cancer undergoing radiotherapy. Methods: Totally 68 patients with cervical cancer undergoing radiotherapy from February 2016 to February 2018 were included in the study. According to the random method of drawing lots, they were divided into two groups, 34 cases each. The control group was given routine nursing intervention, while the observation group was given cancer nursing plan based on risk concept. The intervention time was from the day of admission to the end of discharge. Comparing the incidence of complications between the two groups, the self-care ability implementation scale and the Chinese version of the World Health Organization quality of life scale were used to evaluate the self-care ability and quality of life before and after the intervention. Results: The incidence of complications was 14.70% (5/34) in the observation group and 38.23% (13/34) in the control group, with statistically significant difference (t=4.836, P<0.05).Before intervention, there was no significant difference in scores of each sub-item and total score of self-care ability implementation scale between the two groups (t=0.336-1.224, P>0.05). After intervention, the health knowledge level, self-concept, self-responsibility, self-care skills and total score of the observation group were (48.37±4.10), (27.56±4.12), (26.56±5.09), (29.54±5.87), (132.02±19.15) points, respectively. After intervention, the scores of the above dimensions and the total scale in the control group were (44.10±3.74), (24.16±3.47), (20.40±4.12), (24.13±3.65) and (112.78±14.97) points, respectively, with statistically significant differences (t=3.680-5.485, P<0.05). Before intervention, there was no significant difference in sub-item scores and total scores of QOL between the two groups (t=0.151-0.996, P>0.05); After the intervention, the observation group physiological, psychological, social relations, the environment and total score of (24.85±2.63), (21.34±2.73), (20.76±2.47), (19.07±2.45), (86.02±10.27) points and the control group was (19.09±2.03) points, (17.65±2.13), (17.29±2.30), (16.38±2.37), (70.41±8.82) points, the difference had statistical significance (t=4.601-10.109, P<0.05). Conclusion Tumor care plan based on risk concept can reduce the incidence of complications related to radiotherapy for cervical cancer patients, and improve their self-care ability and quality of life.