Objective:To study the effects of soybean isoflavone (SI) on metabolism of lipids and lipoprotein (a) [Lp(a)] in ovariectomized rats . Methods:Senventy female Sprague- Dawley (SD) rats were randomly divided into 7 groups according to the levels of total cholesterol (TC) in serum: high-lipid (HF) group, estrogen (EG) group, low-dose SI (L-SI) group, middle-dose SI (M-SI) group, high-dose SI (H-SI) group, sham group and normal control (NC) group. One week after bilateral ovaries were extirpated, except sham and NC group, estrogen, different doses of SI or deionized water were fed i.g. for 12 w. Except NC group, the other groups were fed high fat diet. Body weights were weighed every week and blood and heart were collected at the end of experiment. The serum TC, triglyceride(TG), high or low density lipoprotein-cholesterol (HDL-C, LDL-C), Lp (a), and antioxidative enzymes activities were assayed. Results:After SI intervention, the levels of LDL-C in SI groups were significantly lower than in HF group but higher than in NC group. The levels of Lp (a) were also changed, but there was almost no effect on HDL-C. Persistent intervention with SI can reduce TC, TG , and protect cadiocyte’s actin filament andmitochondrial ultramicrostructure from damage as shown in HF group. The ultramicroscopic pictures in EG and H-SI group almost resembled NC group. Conclusion:Persistent intervention of high-dose SI can reduce the levels of LDL-C, TC, TG and protect the myocardiac damages due to high fat diet in ovariectomized rats.

Objective To investigate the pathological and magnetic resonance imaging(MRI)characteristics of orbital diffuse large B-cell lymphoma(DLBCL).Methods A total of 48 patients with orbital DLBCL were selected via a retrospective case-control study in the orbital DLBCL group,and 5 1 patients with DLBCL of primary central nervous system during the same period were included in primary DLBCL group.The clinical characteristics and MRI features of the orbital DLBCL group were analyzed,and the pathological characteristics and peripheral blood platelet-to-lymphocyte ratio(PLR),neutrophil-to-lymphocyte ratio(NLR),and lymphocyte-to-monocyte ratio(LMR)were com-pared between the two groups.Results The main clinical manifestations of orbital DLBCL patients in-cluded local orbital mass in 48 cases(100.00％),limited ocular motility in 38 cases(79.17％),ex-ophthalmos in 33 cases(68.75％),decreased visual acuity in 25 cases(52.08％),diplopia in 17 cases(35.42％),and epistaxis in 9 cases(18.75％).Orbital DLBCL predominantly occurred in the extraconal space(54.17％),with lesions mostly located above the orbit(52.08％).T1-weighted im-ages mainly showed intermediate signal intensity(60.42％),T2-weighted images mainly showed in-termediate(56.25％)and high signal intensity(29.17％),diffusion-weighted images mainly showed high signal intensity(58.33％),and apparent diffusion coefficient maps mainly showed low signal intensity(60.42％).There were no statistically significant differences in histopathological subtype,CD20 positive expression,CD79a positive expression,CD45RO positive expression,International Prognostic Index score,and pathological stage between the two groups(P＞0.05).The PLR in the orbital DLBCL group was higher,while NLR and LMR were lower than that in the primary DLBCL group(P＜0.05).Conclusion Orbital DLBCL exhibits specific clinical manifestations and MRI characteristics.MRI can serve as the primary diagnostic tool,and its combination with pathological immunohistochemical analysis and peripheral blood PLR,NLR,and LMR test results can improve the accuracy and timeliness of diagnosis.

Objective To investigate the pathological and magnetic resonance imaging(MRI)characteristics of orbital diffuse large B-cell lymphoma(DLBCL).Methods A total of 48 patients with orbital DLBCL were selected via a retrospective case-control study in the orbital DLBCL group,and 5 1 patients with DLBCL of primary central nervous system during the same period were included in primary DLBCL group.The clinical characteristics and MRI features of the orbital DLBCL group were analyzed,and the pathological characteristics and peripheral blood platelet-to-lymphocyte ratio(PLR),neutrophil-to-lymphocyte ratio(NLR),and lymphocyte-to-monocyte ratio(LMR)were com-pared between the two groups.Results The main clinical manifestations of orbital DLBCL patients in-cluded local orbital mass in 48 cases(100.00％),limited ocular motility in 38 cases(79.17％),ex-ophthalmos in 33 cases(68.75％),decreased visual acuity in 25 cases(52.08％),diplopia in 17 cases(35.42％),and epistaxis in 9 cases(18.75％).Orbital DLBCL predominantly occurred in the extraconal space(54.17％),with lesions mostly located above the orbit(52.08％).T1-weighted im-ages mainly showed intermediate signal intensity(60.42％),T2-weighted images mainly showed in-termediate(56.25％)and high signal intensity(29.17％),diffusion-weighted images mainly showed high signal intensity(58.33％),and apparent diffusion coefficient maps mainly showed low signal intensity(60.42％).There were no statistically significant differences in histopathological subtype,CD20 positive expression,CD79a positive expression,CD45RO positive expression,International Prognostic Index score,and pathological stage between the two groups(P＞0.05).The PLR in the orbital DLBCL group was higher,while NLR and LMR were lower than that in the primary DLBCL group(P＜0.05).Conclusion Orbital DLBCL exhibits specific clinical manifestations and MRI characteristics.MRI can serve as the primary diagnostic tool,and its combination with pathological immunohistochemical analysis and peripheral blood PLR,NLR,and LMR test results can improve the accuracy and timeliness of diagnosis.