12.08g herbs/kg.The overall effective rate for coronary heart disease was86.8%.CONCLUSION:Danzhisuxin capsule is appropriate in formulation and feasible in preparation technique.The method of quality control is reli?able.No toxic reactions were found and the clinical effect was satisfactory.

Diabetic kidney disease （DKD） has become the first cause of chronic kidney disease （CKD） hospitalisation in China， and is also the main cause of end-stage renal disease （ESRD） and new haemodialysis. DKD has an insidious onset， low awareness， continuous progression， and poor prognosis. Moreover， there is still a lack of effective medication and management. Accurate assessment and identification of high-risk patients with poor clinical prognosis of DKD， as well as early intervention， is of great significance to the improvement of survival rate， quality of life， and prognosis for patients with DKD. Current methods of DKD prognosis assessment mainly include pathological typing， clinical indicators， mathematical models， and biomarkers. Various methods provide means for early prediction and intervention of DKD prognosis， but each has its own advantages and disadvantages. This article provides a review of recent research progress， conducts an in-depth analysis of the application of various DKD prognostic assessment methods in clinical practice， and further explores the potential for combining different methods. It aims to provide a theoretical basis for optimizing diagnostic and treatment processes and for the exploration and development of future DKD prognostic assessment methods.

Objective:To examine the association between the clustering of adverse childhood experiences (ACEs) and sleep quality in middle-aged and older Chinese adults.Methods:Data were from the Life History Survey in 2014 and the third wave follow-up survey in 2015 of China Health and Retirement Longitudinal Study (CHARLS). A total of 10 824 participants aged 45 years and above were included in this study. According to the number of ACEs, the participants were divided into four groups: 0, 1, 2-3 and≥4 ACEs. The multivariate logistic regression model was used to analyze the association of ACEs clustering with inappropriate sleep duration and poor sleep quality in middle-aged and older adults.Results:Among the 10 824 participants with an average age of (60.83±9.06) years, 5 211 (48.14%) were males. About 6 111 participants (56.64%) had inappropriate sleep duration, and 3 640 participants (33.63%) had poor sleep quality. After adjusting for covariates including gender, age, residence, marital status, education, household consumption, BMI, smoking, drinking, and depression in adulthood, compared with the 0 ACE group, the risk of inappropriate sleep duration was significantly increased in the 2-3 ACEs group and≥4 ACEs group, while ORs (95% CIs) were 1.26 (1.12-1.41) and 1.43 (1.23-1.66), respectively. The risk of poor sleep quality in the 2-3 ACEs group and≥4 ACEs group was also significantly higher than that in the 0 ACE group, while ORs (95% CIs) were 1.28 (1.12-1.46) and 1.53 (1.29-1.80), respectively. Conclusion:ACEs clustering in childhood could negatively affect sleep duration and quality in middle-aged and older Chinese adults.

Objective:To examine the association between the clustering of adverse childhood experiences (ACEs) and sleep quality in middle-aged and older Chinese adults.Methods:Data were from the Life History Survey in 2014 and the third wave follow-up survey in 2015 of China Health and Retirement Longitudinal Study (CHARLS). A total of 10 824 participants aged 45 years and above were included in this study. According to the number of ACEs, the participants were divided into four groups: 0, 1, 2-3 and≥4 ACEs. The multivariate logistic regression model was used to analyze the association of ACEs clustering with inappropriate sleep duration and poor sleep quality in middle-aged and older adults.Results:Among the 10 824 participants with an average age of (60.83±9.06) years, 5 211 (48.14%) were males. About 6 111 participants (56.64%) had inappropriate sleep duration, and 3 640 participants (33.63%) had poor sleep quality. After adjusting for covariates including gender, age, residence, marital status, education, household consumption, BMI, smoking, drinking, and depression in adulthood, compared with the 0 ACE group, the risk of inappropriate sleep duration was significantly increased in the 2-3 ACEs group and≥4 ACEs group, while ORs (95% CIs) were 1.26 (1.12-1.41) and 1.43 (1.23-1.66), respectively. The risk of poor sleep quality in the 2-3 ACEs group and≥4 ACEs group was also significantly higher than that in the 0 ACE group, while ORs (95% CIs) were 1.28 (1.12-1.46) and 1.53 (1.29-1.80), respectively. Conclusion:ACEs clustering in childhood could negatively affect sleep duration and quality in middle-aged and older Chinese adults.