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PURPOSE: Angiotensin(ANG) II regulates tone of penile smooth muscle for erection. ANG III is a product converted from ANG II by aminopeptidase A. The effects of ANG III have not been clarified in the penile corpus cavernosum. The purpose of the present experiment was to determine whether the ANG III has regulatory function in the control of rabbit corpus cavernosum smooth muscle tone. MATERIALS AND METHODS: A strip of rabbit corpus cavernosum was mounted in an organ chamber to measure the isometric tension. We compared the effects of ANG III(10-7M to 10-5M), ANG II(10-8M to 10-6M) and ANG I(10-7M to 10-5M) on the contractility of the corpus cavernosum smooth muscle. RESULTS: ANG III, ANG II, and ANG I contracted corpus cavernosum smooth muscle strips dose-dependently. The contraction of smooth muscle induced by ANG III was 10 fold less by ANG II. Contractile response to ANG III was not attenuated by captopril(angiotensin converting enzyme inhibitor). Contractile response to ANG III was significantly inhibited by Dup 753 of 10-7M(type 1 specific ANG II receptor inhibitor) but not inhibited by PD 123,319 of 10-6M(type 2 specific ANG II inhibitor). CONCLUSIONS: The present results suggest that ANG III is involved in the regulation of corpus cavernosum smooth muscle tone, and contractile effect to ANG III produced via activation of type 1 ANG II (AT1) receptor. The rank order of potency of contraction was as follows, ANG II>ANG IIIANG I.
Angiotensin I* ; Angiotensin II* ; Angiotensin III* ; Angiotensins* ; Glutamyl Aminopeptidase ; Losartan ; Muscle, Smooth*

10.The Effect of Endogenous Angiotensin II in Developing Ovarian Hyperstimulation.

Won Il PARK ; Chan Ho SONG ; Pyung Kil KIM ; Dong Je CHOI ; Ki Hyun PARK ; Byung Chul CHANG

Korean Journal of Obstetrics and Gynecology 1997;40(12):2647-2664

1.Angiotensin converting enqyme inhibitor and angiotensin II AT1 receptor antagonist in progressive renal disease.

2.Lithium Intoxication Induced by Angiotensin II Receptor Blocker/Thiazide Combination Agent.

3.Study of effects of complex aerobatics on serum insulin, cortisol and angiotensin II.

4.Hyperkalemia from preoperative non-steroidal anti-inflammatory drugs and angiotensin II receptor blockers in patients with nephropathy.

5.Renin Angiotensin System in Rabbit Corpus Cavernosum: Functional Characterization of Angiotensin II Receptors.

6.Renin Angiotensin System in Rabbit Corpus Cavernosum: Functional Characterization of Angiotensin II Receptors.

7.Effects of intracerebroventricular angiotensin II on the response to hemorrhage in conscious normotensive and hypertensive rats.

8.Effects of intracerebroventricular angiotensin II on the cardiovasc- ular and endocrine systems in conscius normotensive and hypertensi- ve rats.

9.Effects of Angiotensin III in Rabbit Corpus Cavernosum Smooth Muscle Contraction: Comparing with Angiotensin I and Angiotensin II.

10.The Effect of Endogenous Angiotensin II in Developing Ovarian Hyperstimulation.

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