Introduction: Primary uterine angiosarcoma is a very rare tumour, with only 23 cases described till now. It is a malignant tumour with cells variably recapitulating the morphologic features of an endothelium and expressing immunohistochemical markers of endothelial cells. In general, it is a bulky neoplasm and frequently is at advance stage of disease at presentation. In general, patients with uterine angiosarcoma tend to have a poorer prognosis, mostly related to the aggressive nature and the metastatic potential of these tumours. Case report: We report a rare case of primary uterine angiosarcoma with unusual rhabdoid morphology in a 41-year-old female, who underwent radical hysterectomy and died of disease after 4 months of treatment. Discussion: We described the differential diagnosis of primary angiosarcoma of the uterus that can pose a diagnostic challenge.
Angiosarcoma

Angiosarcoma is a rare and highly aggressive soft tissue sarcoma arising from endothelial cells. It most commonly arises from the skin of the head and neck. The etiology of angiosarcoma is unknown but associated factors include chronic lymphedema, radiation, and exposure to environmental carcinogens.

An 83-year-old Filipino male presented initially with an erythematous patch on the left cheek. Over the course of 2 months, he had two different otorhinolaryngology consults and underwent courses of oral antibiotics with no relief. The lesion evolved into an indurated and ulcerated plaque involving the left cheek, eyelid, and medial face. Subsequent Rheumatology consult resulted in autoimmune laboratory tests being requested which all turned out to be normal. Finally, upon referral to Dermatology, a wedge skin biopsy was done. Histopathologic findings were suspicious for angiosarcoma. The specimen stained positive with CD31, and this confirmed the diagnosis. The patient was referred to Medical Oncology for further evaluation and management. The patient exhibited reluctance to undergo additional diagnostic procedures, hospital admission, and treatment. Progressive tumor enlargement led to its associated complications including nasal airway obstruction. The patient died in the course of 3 months after definitive diagnosis.

The clinical presentation of cutaneous angiosarcoma is nonspecific, often starting as a bruise-like patch. Diagnosis relies heavily on a high index of suspicion and histopathology. It is important to catch angiosarcoma early to offer a better prognosis for the patient. This case highlights the role of Dermatologists in a multi-specialty team approach setting.

The exact local prevalence of angiosarcoma of the breast is unknown. The challenge in pinning down the incidence is due it its rarity and possible difficulty in diagnosis since it may mimic other benign breast disorders. We are reporting a case of a 21-year-old female Filipino patient who presented with a 2cm x 2cm palpable mass on the upper outer quadrant of her right breast initially diagnosed through cytology as hemangioma and was later found out to have angiosarcoma of the breast after mastectomy. This is to illustrate the clinical presentation, methods of diagnosis, surgical management, and consequently better understanding of this clinical entity.

Breast cancer is increasing and is the most common cancer among females in Brunei Darussalam. Most are ductal carcinoma. We report a case of a 40-year-old woman who was diagnosed with primary angiosarcoma of the right breast, a rare condition. To the best of our knowledge this is the only reported case in Brunei Darussalam. She underwent lumpectomy followed by mastectomy as the resection margins were not clear. No adjuvant therapy was given because the size of tumour was small, there was no residual tumor in mastectomy specimen and she had no distant metastasis.
Angiosarcoma of the breast ; Breast Neoplasm ; Breast Self-Examination ; Tumour

No abstract available.
Hemangiosarcoma*

No abstract available.
Hemangiosarcoma

Angiosarcoma is a rare tumor, and it is highly unusual for it to appear in bone as a primary lesion. Review of literature revealed that 38 such lesions have bsen recorded since 1925, when Codman wrote that they had as yet registered no case which could be considered a typical angiosarcoma prior to that date. Recently we encountered one tumor developed in the distal end of a clavicle which was confirmed as angiosarcoma by pathologic study. This case is presented with a review of literature.
Clavicle ; Hemangiosarcoma

No abstract available in English.
Hemangiosarcoma ; Osteomyelitis

Diagnostic radiologic studies for angiosarcoma are usually non-specific, but selective angiography is notablyexceptional, and there had been a few reports of CT or US featurs of hepatic or splenic angiosarcoma. We recentlyexperienced a case of hepatic and splenic angiosarcoma demonstrated by CT, US and selective angiogram in34-year0old man.
Angiography ; Hemangiosarcoma

No abstract available.
Breast* ; Hemangioma* ; Hemangiosarcoma*