Angiolymphoid Hyperplasia with Eosinophilia ; diagnosis ; pathology ; therapy ; Child ; Humans ; Male

Adult ; Angiolymphoid Hyperplasia with Eosinophilia ; diagnosis ; therapy ; Diagnosis, Differential ; Humans ; Male ; Prognosis

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign uncommon disorder of uncertain etiology. It presents as solitary or multiple intradermal or subcutaneous red to brown papules or nodules usually on the head and neck. Overlying epidermis is usually intact. Oral involvement such as lip or oral mucosa is quite rare, and presents as a nodule, macule, plaque, tumor, and ulcer. We report a 68-year-old female patient presenting erythematous ulcerated and crusted patch on the lower lip. Histopathological diagnosis was ALHE and overlying actinic cheilitis.
Actins ; Aged ; Angiolymphoid Hyperplasia with Eosinophilia* ; Cheilitis ; Diagnosis ; Epidermis ; Female ; Head ; Humans ; Lip* ; Mouth Mucosa ; Neck ; Ulcer*

Kimura disease is a rare idiopathic chronic inflammatory disorder. It typically presents in the head and neck area, whereas bilateral involvement is unusual. Its diagnosis requires it to be differentiated from other inflammatory diseases and from head and neck tumors. Treatment methods include conservative management, steroid administration, radiotherapy, and surgery; however, no single treatment of choice has been established. Herein, we report an unusual presentation of Kimura disease with bilateral parotid involvement. This case was treated by surgical excision.
Angiolymphoid Hyperplasia with Eosinophilia* ; Diagnosis ; Head ; Head and Neck Neoplasms ; Neck ; Parotid Neoplasms ; Radiotherapy

Kimura disease is a rare idiopathic chronic inflammatory disorder. It typically presents in the head and neck area, whereas bilateral involvement is unusual. Its diagnosis requires it to be differentiated from other inflammatory diseases and from head and neck tumors. Treatment methods include conservative management, steroid administration, radiotherapy, and surgery; however, no single treatment of choice has been established. Herein, we report an unusual presentation of Kimura disease with bilateral parotid involvement. This case was treated by surgical excision.
Angiolymphoid Hyperplasia with Eosinophilia* ; Diagnosis ; Head ; Head and Neck Neoplasms ; Neck ; Parotid Neoplasms ; Radiotherapy

Kimura's disease is a rare, benign, slow-growing chronic inflammatory swelling with a predilection for the head and neck region and is almost always with peripheral blood eosinophilia and elevated serum IgE levels. It is endemic in Asian males and rare in Western people. Surgical excision of the lesion is the first line therapy. Drug and radiation therapy have to be considered for the refractory lesions.
Angiolymphoid Hyperplasia with Eosinophilia ; diagnosis ; Asian Continental Ancestry Group ; Eosinophilia ; pathology ; Humans ; Immunoglobulin E ; blood ; Inflammation ; pathology ; Male ; Neck ; pathology

A 35-year-old woman presented with history of a painless, slow-growing nodule in a left eye caruncle over the last 2 months. The visual acuity was 20 / 20 and the ocular movements were in the normal range. The venereal disease research laboratory test, erythrocyte sedimentation rate, serum angiotensin converting enzyme level, and chest radiograph were all normal. An excisional biopsy was done to confirm the diagnosis. A 1.3 x 0.5 x 0.3 cm sized nodule was extracted and sent for histopathologic examination. Hematoxylin-eosin staining showed follicular hyperplasia with perifollicular fibrosis, an eosinophil infiltrate, and proliferation of capillary vessels. The capillaries were lined by normal-appearing, flat, spindle-shaped endothelial cells. On the basis of these histopathologic findings, the diagnosis of Kimura disease in a caruncle was established. This is the first report describing Kimura disease localized to a caruncle. Kimura disease should be suspected and included in the differential diagnosis of a caruncular mass lesion.
Adult ; Angiolymphoid Hyperplasia with Eosinophilia/*diagnosis ; Asian Continental Ancestry Group ; Conjunctiva/*pathology ; Conjunctival Diseases/*diagnosis ; Diagnosis, Differential ; Female ; Humans

A 35-year-old woman presented with history of a painless, slow-growing nodule in a left eye caruncle over the last 2 months. The visual acuity was 20 / 20 and the ocular movements were in the normal range. The venereal disease research laboratory test, erythrocyte sedimentation rate, serum angiotensin converting enzyme level, and chest radiograph were all normal. An excisional biopsy was done to confirm the diagnosis. A 1.3 x 0.5 x 0.3 cm sized nodule was extracted and sent for histopathologic examination. Hematoxylin-eosin staining showed follicular hyperplasia with perifollicular fibrosis, an eosinophil infiltrate, and proliferation of capillary vessels. The capillaries were lined by normal-appearing, flat, spindle-shaped endothelial cells. On the basis of these histopathologic findings, the diagnosis of Kimura disease in a caruncle was established. This is the first report describing Kimura disease localized to a caruncle. Kimura disease should be suspected and included in the differential diagnosis of a caruncular mass lesion.
Adult ; Angiolymphoid Hyperplasia with Eosinophilia/*diagnosis ; Asian Continental Ancestry Group ; Conjunctiva/*pathology ; Conjunctival Diseases/*diagnosis ; Diagnosis, Differential ; Female ; Humans

A 48-year-old middle aged male presented swelling lymph nodes and mass in neck for 5 years. Physical examination shows swollen mass in head and neck regions. The masses could be touched in bilateral parotids and neck with a little movement and moderate tenderness. The level of IgG was normal, but Eosinophi count was high. The function of heart liver and kidney was normal. The result of B-mode ultrasonography reveals bilateral parotids and subcutaneous near parotids were widely swollen and several swollen lymph nodes in neck. pathological examination displays features of a large number of lymph follicles hyperplasia, acidophilic granulocyte infiltration, capillary hyperplasia and fibrosis of different level. The disease were eventually diagnosed by pathological examination. Method of treatment includes glucocorticoid drug therapy, surgical resection and local radiotherapy. The last treatment of patients with Kimura's disease should be combined with the clinical manifestation of them to determine the individualized treatment, so as to improve the quality of life of patients.
Angiolymphoid Hyperplasia with Eosinophilia ; diagnosis ; pathology ; therapy ; Glucocorticoids ; therapeutic use ; Humans ; Lymph Nodes ; pathology ; Male ; Middle Aged ; Neck ; Parotid Gland ; pathology

PURPOSE: Kimura's disease is a benign slow-growing subcutaneous tumor, which is manifested clinically by one or more inflammatory nodules invading mainly the head and neck. Orbital, eyelid and lacrimal involvement by Kimura disease is rare. We report two cases of Kimura's disease involving the orbit and eyelid , which has not been reported in korea. METHODS: A 16-year-old male patient presented with the chief complaint of upper eyelid swelling and ptosis that was first noticed 15 years ago. Another 16-year-old male patient visited our clinic with multiple nodules involving the head, neck, left upper arm, and the both upper eyelids . Ocular examination of case.1 revealed upper eyelid swelling and redness, painless nodule, and ptosis. In case 1. patient, Orbital MRI scan showed thickening of the superior, inferior, medial rectus muscle, levator palpebrae muscle, and a well-demarcated homogenous mass in the superonasal portion of the left orbit. RESULTS: Histopathologically, the lesions were characterized by lymphoid follicles, infiltration of many eosinophils, lymphocytes, abnormal capillary proliferation and fibrosis. Laboratory findings definitely revealed peripheral blood eosinophilia in both patients. CONCLUSIONS: Kimura's disease should be suspected and considered in the differential diagnosis for the patients with the eyelid swelling and mass.
Adolescent ; Angiolymphoid Hyperplasia with Eosinophilia ; Arm ; Capillaries ; Diagnosis, Differential ; Eosinophilia ; Eosinophils ; Eyelids* ; Fibrosis ; Head ; Humans ; Korea ; Lymphocytes ; Magnetic Resonance Imaging ; Male ; Neck ; Orbit*