No abstract available.
Anesthetics, General* ; Brain Injuries* ; Brain*

No abstract available.
Anesthetics, General ; Child ; Humans ; Propofol

No abstract available.
Anesthetics, General ; Child ; Humans ; Propofol

Many historical general anesthetics have been waxed and waned in the market of anesthetic field, mostly due to organ toxicities related to their metabolism, active metabolites and biodegradation, or other reasons. Modern anesthetics available now are known to undergo metabolism to the extent of clinical insignificance compared with the old ones. However, animal studies provided extensive evidences showing that general anesthetics are neurotoxic or neuroprotective in certain circumstances along with the advancement of knowledge on simultaneous neural injury and healing processes. Until now, there have been few prospective randomized clinical trials conducted to reveal these two issues. In fact, the concerns of the long-term effect of anesthetics on cognitive and behavior decline seem to be in arrears compared with those of the immediate effect of anesthetics, such as the rapidity of onset/offset of action, intraoperative hemodynamic controls or postoperative nausea and vomiting, etc. At present, we anesthesiologists, are challenged with the rapidly changing environments, in which the elderly population grows or a variety of sedation depth are required especially for patients of extreme ages. Concerns on anesthetics' effects with double edged sword are mounting from basic scientists and/or anesthesiologists, as well as public society, such as FDA in US. Therefore, I review the current findings from animal and human researches regarding the anesthetic potentials for neuroprotection and/or neurotoxicity under certain circumstances and their links with findings of clinical researches.
Aged ; Anesthetics ; Anesthetics, General ; Animals ; Hemodynamics ; Humans ; Postoperative Nausea and Vomiting

Various anesthetic agents have successfully used for patients undergoing surgery for pheochromocytoma removal. A review of the literature on the anenthetic marnagement of pheochromocytoma discloses no general agreement regarding choice of an anesthetic agent. It would appear that the selection of the anesthetic agent is not as important as the proper management of the patient Previously the anesthetic experience of a case of pheochromocythma removal managed under methoxyflurane anesthesis has been reported by us. Thereafter we have had another five eases of pheochromocytoma removal operation under general anesthesia, employing methoxyflmrane as a primary anesthetic, with relatively satisfactory results.
Anesthesia, General ; Anesthetics ; Humans ; Methoxyflurane* ; Pheochromocytoma*

BACKGROUND: Cerebral state index (CSI) is an anesthesia depth monitor alternative to bispectral index (BIS). Published comparative studies have used propofol or sevoflurane. However, studies using desflurane have not been reported yet. Different volatile anesthetics have different electroencephalography signatures. The performance of CSI may be different in desflurane anesthesia. Therefore, the objective of this study was to compare CSI and BIS during desflurane anesthesia. METHODS: Thirty-three patients were recruited. Desflurane and remifentanil were used to maintain general anesthesia. BIS and CSI were recorded simultaneously every minute. End-tidal concentration of desflurane was maintained at 4% from the beginning of surgery for 5 minutes. Pairwise data of CSI and BIS were obtained five times at one-minute intervals. This process was repeated in the order of 6%, 8%, and 10%. RESULTS: BIS and CSI were negatively correlated with the end-tidal concentration of desflurane with a similar degree of correlation (correlation coefficient BIS: –0.847, CSI: –0.844). The relationship between CSI and BIS had a good linearity with a slope close to 1 (R2 = 0.905, slope = 1.01). For the relationship between CSI and BIS at each end-tidal concentration of desflurane, CSI and BIS showed good linearity in 4% and 10% (R2 = 0.559, 0.540). However, the linearity and slope were decreased in 6% and 8% (R2 = 0.163, 0.014). CONCLUSIONS: CSI showed an equivalent degree of overall performance compared to BIS in desflurane anesthesia. Accounting for previous literature, CSI can be used as a good substitute for BIS regardless of the kind of anesthetics used.
Anesthesia* ; Anesthesia, General ; Anesthetics ; Electroencephalography ; Humans ; Propofol

Polyuria is occasionally observed during general anesthesia. Usually urine output during general anesthesia is decreased because of anesthetic agents. The authors came across with a case of polyruia during sevoflurane anesthesia which occurred after induction of anesthesia. Polyuria is a nonspecific symptom, but can cause many serious complications. Therefore, it is very important to investigate the cause thoroughly and treat patient appropriately.
Anesthesia ; Anesthesia, General ; Anesthetics ; Humans ; Methyl Ethers ; Polyuria ; Porphyrins

General anesthesia is the most common method used for operations and volatile anesthetics are commonly used for general anesthesia. Moreover, it is known that the newly developed volatile anesthetics are safe in liver and kidney. However, inorganic fluoride levels increase with anesthetic time and increase the possibility of renal toxicity and repeat a anesthesia in short term period increase the possibility of hepatic failure. We experienced 2 cases who received general anesthesia with volatile anesthetics more than 50 times without any organ failure. Here, we review the anesthetic records and preoperative laboratory findings of each operation.
Anesthesia ; Anesthesia, General* ; Anesthetics ; Fluorides ; Kidney ; Liver ; Liver Failure

The effect of general anesthesia for the cesarean section varies according to anesthetic type, drug dosage and concentration of the anesthetics. Thus, the authors studied the effects of general anesthesia for twenties healthy parturients according to anesthetic agents. The method consisted of administration of halothane(Group I, N=IO) or a combination of fentanyl and droperidol(GroupII, N=10). We checked the hemoglonin value, rbc number on the pre-operative day, immediate post-operative, post-operative seocond and post-operative fifth day. The results were as follows. In Group I, hemoglobin value and rbc number significantly decreased on the post-operative secone and fifth day(p<0.025). But in Group II, there are no differences in hemoglonin value and RBC number.
Anesthesia, General ; Anesthetics ; Cesarean Section* ; Female ; Fentanyl ; Halothane* ; Pregnancy

BACKGROUND: We have used thiopental sodium as an induction agent traditionally, but a recently introduced induction agent, propofol, is gaining popularity among anesthesiologists. The purpose of this study was to compare the difference in induction time by measuring the hypnotic time. METHODS: Sixty adult patients (ASA class I or II) scheduled for elective surgery under general anesthesia were randomly assigned to receive 5 mg/kg of thiopental (Group I) or 2 mg/kg of propofol (Group II), respectively, as an induction agent. The induction time by using Eyelash reflex (from the start of administration of induction agent to the time of reflex loss) was measured after the administration of thiopental and propofol and compared between these two groups. RESULTS: The induction time using ER in Group II (52.2 +/- 12.0 s) was not significantly longer than Group I (50.4 +/-9.4 s). CONCLUSIONS: We concluded that propofol had the same induction time as thiopental for induction of general anesthesia.
Adult ; Anesthesia, General ; Anesthetics ; Humans ; Propofol* ; Reflex ; Thiopental*