No abstract available.
Anesthesia, Conduction

Background: Serratus anterior plane block (SPB) is a relatively new regional anesthetic technique that provides long-lasting anesthesia, extended postoperative analgesia, and demonstrates less consumption of opioid analgesic compared to local infiltration anesthesia (LIA). Objective: To compare the outcomes of SPB and LIA as anesthetic techniques among patients undergoing chest tube thoracostomy (CTT) insertion. Design: Cohort study. Setting: Department of Surgery, Southern Philippines Medical Center, from October 2017 to May 2019. Participants: 110 male and female patients aged >18 years old undergoing CTT given either SPB or LIA. Main outcome measures: Mean VAS during the procedure, at PACU, and 4, 8, 12, 16, 18, and 24 hours postoperatively. Main results: Of the 110 patients undergoing CTT in this study, 55 (50%) where under SPB, and the remaining 50% where under LIA. Compared to those under LIA, patients under the SPB group had significantly lower mean VAS during the procedure (4.02 ± 1.43 vs 2.76 ± 1.35; p<0.0001), and at post-anesthesia care unit (4.25 ± 1.87 vs 3.15 ± 1.56; p=0.0010). The mean level of physician's satisfaction on the procedure was significantly higher in the SPB group than in the LIA group (3.56 ± 0.50 vs 2.96 ± 0.33; p<0.0001). The mean dose of fentanyl as supplemental anesthetic agent was significantly higher in the LIA group than those in the SPB group (1.38 ± 0.59 vs 0.95 ± 0.29; p<0.0001). Similarly, the mean dose of nalbuphine, as rescue opioid dose, was significantly higher in the LIA group than in the SPB group (2.16 ± 0.57 vs 1.53 ± 0.57; p<0.0001). Conclusion Patients under SPB who underwent CTT had less pain during the procedure and at the PACU, and used lower doses of the supplemental anesthetic agent (fentanyl) during the procedure, and of the rescue opioid analgesic (nalbuphine), postoperatively.
Anesthesia, Conduction

Background and Objective: Hip fractures among the elderly continue to be a serious public health concern. Hip fractures result in extremely painful injuries and given the higher risk of the elderly for complications, managing pain in this population can be challenging. This study aimed to describe the outcomes of peripheral nerve blocks on elderly patients with fragility hip fractures who will undergo elective or emergency hip surgery. Methods: A single-center prospective cohort study was conducted at the Philippine General Hospital from May 2022 to November 2022. Patients included were aged 60 years old and above with fragility hip fracture, for elective or emergency hip surgery, and with American Society of Anesthesiologists (ASA) Physical Status Score 1–3. Patients’ baseline profile, intraoperative characteristics, and postoperative outcomes were collected using a standard data collection form. The data collector was blinded to the type of block performed. Results: A total of 29 patients who underwent hip surgery were included in the study. Most (65.5%) had Subarachnoid block + Peripheral Nerve Block (SAB+PNB) while 24.1% had General Anesthesia + Peripheral Nerve Block (GA+PNB) and 10.3% had no Peripheral Nerve Block (PNB). The median Numerical Rating Scale (NRS) 30 minutes post block was similar (p=0.977) in those who had PNB blocks (GA+PNB = 0, SAB+PNB = 0). The median NRS at rest during Postoperative day 1 (POD1) was significantly highest (p=0.023) in the No PNB group (3) than in both GA+PNB (0) and SAB+PNB (0). In contrast, the median NRS at rest during POD2 was similar (p=0.713) in the three groups (GA+PNB = 0, SAB+PNB = 0, No PNB = 0). The median NRS at motion during POD1 was significantly highest (p=0.008) in the No PNB group (6) than in both GA+PNB (0) and SAB+PNB (1). Also, the median NRS at motion during POD2 was significantly highest (p=0.009) in No PNB group (4) than in both GA+PNB (0) and SAB+PNB (1). Median Morphine Milligram Equivalent (MME) of postoperative opioid was significantly higher in the No PNB group among the three groups (p=0.047). The median satisfaction score (p=0.210), median delirium score at POD2 (p=0.993), and median length of hospitalization (p=0.173) were all similar in the three groups. Conclusion Peripheral nerve block is effective in elderly patients undergoing surgery for fragility hip fractures. It results in lower pain scores and can be administered with equal effectiveness either with general anesthesia or with subarachnoid block. Mortality rate, incidence of delirium, and hospital length of stay did not vary between those with and without peripheral nerve block.
regional anesthesia ; anesthesia, conduction

Background and Objective: Hip fractures among the elderly continue to be a serious public health concern. Hip fractures result in extremely painful injuries and given the higher risk of the elderly for complications, managing pain in this population can be challenging. This study aimed to describe the outcomes of peripheral nerve blocks on elderly patients with fragility hip fractures who will undergo elective or emergency hip surgery. Methods: A single-center prospective cohort study was conducted at the Philippine General Hospital from May 2022 to November 2022. Patients included were aged 60 years old and above with fragility hip fracture, for elective or emergency hip surgery, and with American Society of Anesthesiologists (ASA) Physical Status Score 1–3. Patients’ baseline profile, intraoperative characteristics, and postoperative outcomes were collected using a standard data collection form. The data collector was blinded to the type of block performed. Results: A total of 29 patients who underwent hip surgery were included in the study. Most (65.5%) had Subarachnoid block + Peripheral Nerve Block (SAB+PNB) while 24.1% had General Anesthesia + Peripheral Nerve Block (GA+PNB) and 10.3% had no Peripheral Nerve Block (PNB). The median Numerical Rating Scale (NRS) 30 minutes post block was similar (p=0.977) in those who had PNB blocks (GA+PNB = 0, SAB+PNB = 0). The median NRS at rest during Postoperative day 1 (POD1) was significantly highest (p=0.023) in the No PNB group (3) than in both GA+PNB (0) and SAB+PNB (0). In contrast, the median NRS at rest during POD2 was similar (p=0.713) in the three groups (GA+PNB = 0, SAB+PNB = 0, No PNB = 0). The median NRS at motion during POD1 was significantly highest (p=0.008) in the No PNB group (6) than in both GA+PNB (0) and SAB+PNB (1). Also, the median NRS at motion during POD2 was significantly highest (p=0.009) in No PNB group (4) than in both GA+PNB (0) and SAB+PNB (1). Median Morphine Milligram Equivalent (MME) of postoperative opioid was significantly higher in the No PNB group among the three groups (p=0.047). The median satisfaction score (p=0.210), median delirium score at POD2 (p=0.993), and median length of hospitalization (p=0.173) were all similar in the three groups. Conclusion Peripheral nerve block is effective in elderly patients undergoing surgery for fragility hip fractures. It results in lower pain scores and can be administered with equal effectiveness either with general anesthesia or with subarachnoid block. Mortality rate, incidence of delirium, and hospital length of stay did not vary between those with and without peripheral nerve block.
regional anesthesia ; anesthesia, conduction

No abstract available.
Anesthesia, Conduction* ; Emergencies*

No abstract available.
Anesthesia, Conduction* ; Muscular Dystrophies*

No abstract available.
Anesthesia, Conduction* ; Peripheral Nerves* ; Ultrasonography*

No abstract available in English.
Anesthesia, Conduction* ; Arrhythmias, Cardiac* ; Cannabis*

BACKGROUND: Whether regional anesthesia may help to prevent disease recurrence in cancer patients is still controversial. The stage of cancer at the time of diagnosis is a key factor that defines prognosis and is one of the most important sources of heterogeneity for the treatment effect. We sought to update existing systematic reviews and clarify the effect of regional anesthesia on cancer recurrence in late-stage cancer patients. METHODS: Medline, Embase, and Cochrane Library were searched from inception to September 2020 to identify randomized controlled trials (RCTs) and cohort studies that assessed the effect of regional anesthesia on cancer recurrence and overall survival (OS) compared with general anesthesia. Late-stage cancer patients were primarily assessed according to the American Joint Committee on Cancer Cancer Staging Manual (eighth edition), and the combined hazard ratio (HR) from random-effects models was used to evaluate the effect of regional anesthesia. RESULTS: A total of three RCTs and 34 cohort studies (including 64,691 patients) were identified through the literature search for inclusion in the analysis. The risk of bias was low in the RCTs and was moderate in the observational studies. The pooled HR for recurrence-free survival (RFS) or OS did not favor regional anesthesia when data from RCTs in patients with late-stage cancer were combined (RFS, HR = 1.12, 95% confidence interval [CI]: 0.58-2.18, P = 0.729, I2 = 76%; OS, HR = 0.86, 95% CI: 0.63-1.18, P = 0.345, I2 = 48%). Findings from observational studies showed that regional anesthesia may help to prevent disease recurrence (HR = 0.87, 95% CI: 0.78-0.96, P = 0.008, I2 = 71%) and improve OS (HR = 0.88, 95% CI: 0.79-0.98, P = 0.022, I2 = 79%). CONCLUSIONS RCTs reveal that OS and RFS were similar between regional and general anesthesia in late-stage cancers. The selection of anesthetic methods should still be based on clinical evaluation, and changes to current practice need more support from large, well-powered, and well-designed studies.
Anesthesia, Conduction ; Humans ; Neoplasms ; Recurrence

Background: Compared to adult patients undergoing upper limb surgery who receive general endotracheal anesthesia (GETA), those who receive peripheral nerve block (PNB) have better postoperative outcomes. Objective: To compare postoperative outcomes of PNB and GETA for orthopedic upper limb surgery among pediatric patients. Design: Cohort study. Setting: Southern Philippines Medical Center, Davao City, from December 2015 to May 2016. Participants: 94 boys and girls, 3 to 18 years old, who received either PNB or GETA for orthopedic upper limb surgery. Main outcome measures: Postoperative pain by visual analogue scale (VAS), need for postoperative rescue opioid doses. Main results: Of the 94 patients in this study, 47 (50%) received PNB, and the rest received GETA prior to surgery. Patients in the two anesthesia groups were comparable at baseline. The PNB group had lower mean VAS scores compared to the GETA group both at the post-anesthesia care unit (0.70 ± 1.52 versus 4.15 ± 1.78; p<0.001) and at the Orthopedics Ward (0.45 ± 1.49 versus 4.13 ± 1.68; p<0.001). The proportion of patients given postoperative rescue opioid doses was significantly lower in the PNB group (6/47; 12.77%) than in the GETA group (21/47; 44.62%; p=0.0006). Conclusion Pediatric patients for orthopedic upper limb surgery who received PNB had less pain postoperatively and needed postoperative rescue opioid doses less frequently compared to those who received GETA.
Anesthesia, Conduction ; Postoperative Nausea and Vomiting