No abstract available.
Anemia, Iron-Deficiency* ; Diagnosis* ; Iron*

The occurrence of the small intestinal adenocarcinoma is infrequent and the primary adenocarcinoma of the jejunum is rare. The survival of adenocarcinoma of the small bowel does not improve over the past three decades. Although symptoms appeared to be of long duration, most patients were diagnosed with advanced disease. All reports agree that these tumors are difficult to achieve good examination of the small bowel by both clinician and radiologist, so it cause a significant delay in diagnosis. The survival of these tumors appear to correlate with stage at presentation, and therefore early and aggressive diagnostic intervention seems to improve the outlook. We report a case of primary jejunal adenocarcinoma assoeiated with iron deficiency anemia with literatures review.
Adenocarcinoma* ; Anemia, Iron-Deficiency ; Diagnosis ; Humans ; Jejunum

Anemia, Iron-Deficiency ; diagnosis ; prevention & control ; Child, Preschool ; Humans ; Infant ; Iron ; deficiency ; Reference Values ; Universal Precautions

Adult ; Anemia, Iron-Deficiency ; diagnosis ; Female ; Hemoglobins ; analysis ; Humans ; Iron ; deficiency ; Premenopause ; ROC Curve ; Reticulocytes ; chemistry

PURPOSE: Flow cytometric automated reticulocyte analysis is a superior method to manual reticulocyte counting, with respect to precision and sensitivity. Furthermore, flow cytometric analysis is able to measure immature reticulocyte fraction(IRF) and reticulocyte cellular indices(RCI:cell hemoglobin content: CHr, mean cell volume:MCVr, cell hemoglobin concentration mean:CHCMr, distribytion width:RDWr, HDWr, CHDWr). In this study, we investigated the mean values and clinical significances of IRF and RCI in healthy children and pediatric anemia patients. METHODS: IRF and RCI were measured with an automated blood cell analyzer, ADVIA 120(Bayer, USA) using oxazine 750 dye, in 57 healthy children and 61 children with anemia. The anemia group consisted of 27 iron deficiency anemia(IDA) patients and 34 patients with anemia associated with acute infection(AAI). We compared the mean values of IRF and RCI in the control group classified according to age, between anemia groups and the control group, and between the IDA group and the AAI group. RESULTS: For the normal control group, the mean values of IRF, CHr, MCVr and HDWr were higher in neonates when compared to older children. The mean values of IRF and RDWr were significantly higher, and the mean values of CHr and CHCMr were significantly lower in the IDA group when compared to the control group. The mean value of IRF was significantly higher, and the mean value of CHDWr was significantly lower in the AAI group when compared to the control group. The mean values of IRF, CHr and CHCMr were significantly lower in the IDA group when compared to the AAI group. CONCLUSION: We could determine the normal mean values of IRF and RCI in healthy children classified according to age for understanding of hematopoietic response differences according to age. The evaluation of IRF and RCI by automated reticulocyte analyzer seemed to be accurate and clinically useful for the early diagnosis of anemia and the differentiation of IDA from AAI.
Anemia* ; Anemia, Iron-Deficiency ; Blood Cells ; Child ; Early Diagnosis ; Humans ; Infant, Newborn ; Iron ; Reticulocyte Count ; Reticulocytes*

OBJECTIVE: To evaluate the prevalence and characteristics of anemia in the long distance runners. METHOD: Subjects included 61 long distance runners and 40 control. The 61 subjects averaged 39.9+/-4.5 years of age. Long distance runners has been training for at least 6 months. Hemoglobin, iron, total iron binding capacity, reticulocyte count, peripheral blood smear, urine hemosiderin were evaluated. WHO criteria cut off value of hemoglobin for the diagnosis of anemia was used, 13 g/dl in men and 12 g/dl in women. Iron deficiency was defined as the percent transferrin saturation less than 15. The percent transferrin saturation was calculated by dividing the serum iron level by the total iron-binding capacity. RESULTS: Anemia occurred in only 2.0% and 9.0% of the male and female long distance runners respectively and other laboratory findings supported diagnosis of iron deficiency anemia. The percentage of iron deficiency anemia was lower than normal control. Iron deficiency was evident in 6.0% and 18.1% of the male and female long distance runners respectively. CONCLUSION: Recreational long distance runners were at no greater risk for developing a frank anemia than the non-exercising population.
Anemia* ; Anemia, Iron-Deficiency ; Diagnosis ; Female ; Hemosiderin ; Humans ; Iron ; Male ; Prevalence* ; Reticulocyte Count ; Transferrin

A serum ferritin level is now the most sensitive and specific assay for iron deficiency. Incidence of iron deficiency anemia was determined by means of the serum ferritin level and the response to iron therapy, and changes in serum ferritin level were observed in 421 hospitalized pediatric patients with various diseases. The results were as follows : 1. Incidence of anemia was 45% of total hospitalized patients. Incidence of iron deficiency anemia was 5.9% of total patients and 13.3% of patients with anemia. It was most common between 6 moths and 2 years of age. 2. Serum ferritin levels were below 10ng/ml in 20(range;1-8.8ng/ml) and between 13.2 -24.5ng/ml in 5 out of 25 patients with iron deficiency anemia. Determination of the serum ferritin level, therefore, was thought to be an accurate method for the diagnosis of iron deficiency anemia. 3. Mean serum ferritin levels were 152.1ng/ml in total patients, 143.4ng/ml in patients without anemia, 7.9ng/ml in patient with iron deficiency anemia, and 199.9ng/ml in patients with anemia of other causes. Iron deficiency anemia was easily differentiated from the anemia of other causes by serum ferritin level. 4. Serum ferritin levels were elevated to significantly higher level in leukemia, aplastic anemia, rheumatoid arthritis, liver diseases and chronic infections.
Anemia ; Anemia, Aplastic ; Anemia, Iron-Deficiency* ; Arthritis, Rheumatoid ; Diagnosis ; Ferritins ; Humans ; Incidence ; Iron* ; Leukemia ; Liver Diseases ; Moths

Iron deficiency anemia (IDA) and megaloblastic anemia due to vitamin B12 deficiency are well-characterized prototypes of anemia. There is no doubt that IDA is the most common hematologic disorder in Korea and worldwide as well. The diagnosis and treatment of IDA is not a difficult practice usually, however, a caution is required in detecting early-stage iron deficiency and in distinguishing IDA from anemia of chronic disorders such as chronic inflammatory disease, malignancies, chronic liver disease, and chronic renal disease. Administration of a standard iron preparation at a proper dosage over an adequate period is a prerequisite for the successful treatment of IDA, which is sometimes overlooked by both physicians and patients. Early detection and treatment as well as prevention of iron deficiency per se are also required. Pernicious anemia is the most common cause of vitamin B12 deficiency in Western populations. By contrast, the disorder is rare in Korea, although the number of cases seems to be increasing these days. The majority of patients with megaloblastic anemia reveal a history of gastrectomy. Thus, it should be reminded that vitamin B12 supplementation is important to prevent the development of overt deficiency or anemia in these susceptible individuals, since a delay in the treatment of vitamin B12 deficiency may result in an irreversible neurologic deficit.
Anemia* ; Anemia, Iron-Deficiency ; Anemia, Megaloblastic ; Anemia, Pernicious ; Diagnosis ; Gastrectomy ; Humans ; Iron ; Korea ; Liver Diseases ; Neurologic Manifestations ; Renal Insufficiency, Chronic ; Vitamin B 12 ; Vitamin B 12 Deficiency

PURPOSE: Iron deficiency, particularly iron deficiency anemia(IDA) often not only decreases athletic performance but also impairs immune function and leads to other physiologic dysfunctions. This study was designed to assess and compare iron status and the IDA prevalence in female adolescent athletes with those of general adolescent students. METHODS: Physical measurements and hematologic examinations were performed for adolescent female runners(n=32), non-runner athletes(n=78) and apparently healthy students(n=511). Iron deficiency was defined as a serum ferritin concentration <12 ng/mL. The diagnosis of IDA was established when hemoglobin level <12 g/dL was associated with ferritin <12 ng/mL and/or transferrin saturation <16%. RESULTS: The prevalence of ID in the runners' group(40.6%) was significantly higher than that of the non-runner athletes' group(23.1%) and the control group(25.4%). The prevalence of IDA in the runners' group was 31.3%, which was significantly higher than that of the non-runners' group and the control group(7.7% and 16.4%, respectively). CONCLUSION: The prevalence of IDA of Korean adolescent females was relatively high, especially, in female adolescent runners. Screening for anemia and iron status is warranted. It is important to measure for iron nutrition and to enforce effective nutritional education in these groups.
Adolescent* ; Anemia ; Anemia, Iron-Deficiency* ; Athletes* ; Athletic Performance ; Diagnosis ; Education ; Female* ; Ferritins ; Humans ; Iron* ; Mass Screening ; Prevalence ; Transferrin

BACKGROUND: This study was aimed at assessing iron nutrition and lipid panel in adolescent female athletes, which were compared with those in general adolescent students. MATERIALS AND METHODS: Physical measurement and blood examination were done from adolescent female athletes (N=83) and apparently healthy students (N=758). Anemia was defined as a hemoglobin less than 12g/dL. Iron deficiency was defined as a serum ferritin concentration<10ng/mL. The diagnosis of iron deficiency anemia (IDA) was established when a low hemoglobin level (Hb<12g/dL) was associated with ferritin<10ng/mL and/or transferrin saturation<10%. RESULTS: The prevalence of anemia in female athletes aged 11 to 14 years was 22.2%, which was significantly higher than that of comparison group (10.1%). However, there were no significant differences in proportion of iron deficiency (20% vs. 27.4%) and IDA (15.6% vs. 8.9%) between two groups. The prevalence of anemia in female athletes aged 15 to 19 years was 26.3%. The prevalence of iron deficiency and IDA were 31.6% and 21.1%, respectively, which were not significantly different from the comparison group. The mean triglyceride level in the athlete girls was lower than the comparison group. And the mean HDL cholesterol level was higher than the comparison group. CONCLUSION: As the prevalence of iron deficiency and IDA is relatively common in adolescent female athletes, the measurement of iron nutrition is warranted in these groups with nutritional education.
Adolescent* ; Anemia ; Anemia, Iron-Deficiency ; Athletes* ; Cholesterol, HDL ; Diagnosis ; Education ; Female* ; Ferritins ; Humans ; Iron* ; Prevalence ; Transferrin ; Triglycerides