2.Changes in number of erythrocytes and hemoglobin in patients with idiopathic aplastic anemia treated with cyclosporine A.
Journal of Practical Medicine 2002;435(11):28-30
This study involved 27 patients with idiopathic aplastic anemia who were treated from November 1995 to November 1997. Among these, 13 cases received 1.5 mg/kg/day of prednisone and 14 cases received 4 mg/kg/day of cyclosporin-A. Results showed that the number of erythrocytes and hemoglobin have increased in cyclosporin group, but not in prednisone group (p>0.05) during three months of treatment. After 3-month course of treatment, the cyclosporin group had better result in comparison with other group.
Anemia, Aplastic
;
therapy
;
erythrocytes
;
therapeutics
4.Variation of T lympho counts in peripheral blood of idiopathic aplastic anemia patients and the treatment with cyclosporine.
Journal of Medical and Pharmaceutical Information 1999;(12):24-28
From 11/1995 to 4/1999 we treated by prednisone for 15 patients and CsA for 16 ones with idiopathic aplastic anemia. Results:- Prednison did not change significantly TCD3, TCD4 and TCD8 colony count comparing with pre-treatment (P>0.05).- CsA decreased clearly TCD3 colony count after 1st, 6th month (P<0,05). However, TCD4 colony count decreased not significantly (P>0.05). Conclusions: CsA has more suppressive effect on T-cell colonies, mainly TCDz3 and TCD8 than Prednisone and therefore it may be chosen to treat patients with idiopathic aplastic anemia without indication for bone marrow transplantation.
Anemia, Aplastic
;
therapy
;
blood
;
therapeutics
;
cyclosporine
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