1.Surgical Risk and Pathological Results of Emergency Resection in the Treatment of Acutely Obstructing Colorectal Cancers: A Retrospective Cohort Study
Giovanni Domenico TEBALA ; Andrea MINGOLI ; Andrea NATILI ; Abdul Qayyum KHAN ; Gioia BRACHINI
Annals of Coloproctology 2021;37(1):21-28
Purpose:
The treatment of acutely obstructing colorectal cancers is still a matter of debate. The prevailing opinion is that an immediate resection should be performed whenever possible. This study sought to determine whether immediate resection is safe and oncologically valid.
Methods:
We completed a retrospective 2-center cohort study using the medical records of patients admitted for acutely obstructing colorectal cancer under the care of the Colorectal Team, Noble’s Hospital, Isle of Man, and the Emergency Surgery Unit, Umberto I University Hospital, Rome, from March 2013 to May 2017. The primary endpoints were 90-day mortality and morbidity, reoperation rate, and length of stay. The secondary endpoints were status of margins, number of lymph nodes retrieved, and the rate of adequate nodal harvest.
Results:
Sixty-three patients were retrospectively enrolled in the study. Mortality was associated with age > 80 years and Dukes B tumors. The length of hospital stay was shorter in patients who had their resection less than 24 hours from their admission, in those who had laparoscopic resection and in those with distal tumors. The number of lymph nodes retrieved and rate of R0 resections were similar to those reported in elective colorectal surgery and were greater in laparoscopic resections and in patients operated on within 24 hours, respectively.
Conclusion
Immediate resection is a safe and reliable option in patients with acutely obstructing colorectal cancer.
2.Do some patients receive unnecessary parenteral nutrition after pancreatoduodenectomy?Results from an international multicentre study
Thomas B. RUSSELL ; Peter L. LABIB ; Paula MURPHY ; Fabio AUSANIA ; Elizabeth PANDO ; Keith J. ROBERTS ; Ambareen KAUSAR ; Vasileios K. MAVROEIDIS ; Gabriele MARANGONI ; Sarah C. THOMASSET ; Adam E. FRAMPTON ; Pavlos LYKOUDIS ; Manuel MAGLIONE ; Nassir ALHABOOB ; Hassaan BARI ; Andrew M. SMITH ; Duncan SPALDING ; Parthi SRINIVASAN ; Brian R. DAVIDSON ; Ricky H. BHOGAL ; Daniel CROAGH ; Ismael DOMINGUEZ ; Rohan THAKKAR ; Dhanny GOMEZ ; Michael A. SILVA ; Pierfrancesco LAPOLLA ; Andrea MINGOLI ; Alberto PORCU ; Nehal S. SHAH ; Zaed Z. R. HAMADY ; Bilal AL-SARRIEH ; Alejandro SERRABLO ; ; Somaiah AROORI
Annals of Hepato-Biliary-Pancreatic Surgery 2024;28(1):70-79
Background:
s/Aims: After pancreatoduodenectomy (PD), an early oral diet is recommended; however, the postoperative nutritional management of PD patients is known to be highly variable, with some centers still routinely providing parenteral nutrition (PN). Some patients who receive PN experience clinically significant complications, underscoring its judicious use. Using a large cohort, this study aimed to determine the proportion of PD patients who received postoperative nutritional support (NS), describe the nature of this support, and investigate whether receiving PN correlated with adverse perioperative outcomes.
Methods:
Data were extracted from the Recurrence After Whipple’s study, a retrospective multicenter study of PD outcomes.
Results:
In total, 1,323 patients (89%) had data on their postoperative NS status available. Of these, 45% received postoperative NS, which was “enteral only,” “parenteral only,” and “enteral and parenteral” in 44%, 35%, and 21% of cases, respectively. Body mass index < 18.5 kg/m2 (p = 0.03), absence of preoperative biliary stenting (p = 0.009), and serum albumin < 36 g/L (p = 0.009) all correlated with receiving postoperative NS. Among those who did not develop a serious postoperative complication, i.e., those who had a relatively uneventful recovery, 20% received PN.
Conclusions
A considerable number of patients who had an uneventful recovery received PN. PN is not without risk, and should be reserved for those who are unable to take an oral diet. PD patients should undergo pre- and postoperative assessment by nutrition professionals to ensure they are managed appropriately, and to optimize perioperative outcomes.
3.Do some patients receive unnecessary parenteral nutrition after pancreatoduodenectomy?Results from an international multicentre study
Thomas B. RUSSELL ; Peter L. LABIB ; Paula MURPHY ; Fabio AUSANIA ; Elizabeth PANDO ; Keith J. ROBERTS ; Ambareen KAUSAR ; Vasileios K. MAVROEIDIS ; Gabriele MARANGONI ; Sarah C. THOMASSET ; Adam E. FRAMPTON ; Pavlos LYKOUDIS ; Manuel MAGLIONE ; Nassir ALHABOOB ; Hassaan BARI ; Andrew M. SMITH ; Duncan SPALDING ; Parthi SRINIVASAN ; Brian R. DAVIDSON ; Ricky H. BHOGAL ; Daniel CROAGH ; Ismael DOMINGUEZ ; Rohan THAKKAR ; Dhanny GOMEZ ; Michael A. SILVA ; Pierfrancesco LAPOLLA ; Andrea MINGOLI ; Alberto PORCU ; Nehal S. SHAH ; Zaed Z. R. HAMADY ; Bilal AL-SARRIEH ; Alejandro SERRABLO ; ; Somaiah AROORI
Annals of Hepato-Biliary-Pancreatic Surgery 2024;28(1):70-79
Background:
s/Aims: After pancreatoduodenectomy (PD), an early oral diet is recommended; however, the postoperative nutritional management of PD patients is known to be highly variable, with some centers still routinely providing parenteral nutrition (PN). Some patients who receive PN experience clinically significant complications, underscoring its judicious use. Using a large cohort, this study aimed to determine the proportion of PD patients who received postoperative nutritional support (NS), describe the nature of this support, and investigate whether receiving PN correlated with adverse perioperative outcomes.
Methods:
Data were extracted from the Recurrence After Whipple’s study, a retrospective multicenter study of PD outcomes.
Results:
In total, 1,323 patients (89%) had data on their postoperative NS status available. Of these, 45% received postoperative NS, which was “enteral only,” “parenteral only,” and “enteral and parenteral” in 44%, 35%, and 21% of cases, respectively. Body mass index < 18.5 kg/m2 (p = 0.03), absence of preoperative biliary stenting (p = 0.009), and serum albumin < 36 g/L (p = 0.009) all correlated with receiving postoperative NS. Among those who did not develop a serious postoperative complication, i.e., those who had a relatively uneventful recovery, 20% received PN.
Conclusions
A considerable number of patients who had an uneventful recovery received PN. PN is not without risk, and should be reserved for those who are unable to take an oral diet. PD patients should undergo pre- and postoperative assessment by nutrition professionals to ensure they are managed appropriately, and to optimize perioperative outcomes.
4.Do some patients receive unnecessary parenteral nutrition after pancreatoduodenectomy?Results from an international multicentre study
Thomas B. RUSSELL ; Peter L. LABIB ; Paula MURPHY ; Fabio AUSANIA ; Elizabeth PANDO ; Keith J. ROBERTS ; Ambareen KAUSAR ; Vasileios K. MAVROEIDIS ; Gabriele MARANGONI ; Sarah C. THOMASSET ; Adam E. FRAMPTON ; Pavlos LYKOUDIS ; Manuel MAGLIONE ; Nassir ALHABOOB ; Hassaan BARI ; Andrew M. SMITH ; Duncan SPALDING ; Parthi SRINIVASAN ; Brian R. DAVIDSON ; Ricky H. BHOGAL ; Daniel CROAGH ; Ismael DOMINGUEZ ; Rohan THAKKAR ; Dhanny GOMEZ ; Michael A. SILVA ; Pierfrancesco LAPOLLA ; Andrea MINGOLI ; Alberto PORCU ; Nehal S. SHAH ; Zaed Z. R. HAMADY ; Bilal AL-SARRIEH ; Alejandro SERRABLO ; ; Somaiah AROORI
Annals of Hepato-Biliary-Pancreatic Surgery 2024;28(1):70-79
Background:
s/Aims: After pancreatoduodenectomy (PD), an early oral diet is recommended; however, the postoperative nutritional management of PD patients is known to be highly variable, with some centers still routinely providing parenteral nutrition (PN). Some patients who receive PN experience clinically significant complications, underscoring its judicious use. Using a large cohort, this study aimed to determine the proportion of PD patients who received postoperative nutritional support (NS), describe the nature of this support, and investigate whether receiving PN correlated with adverse perioperative outcomes.
Methods:
Data were extracted from the Recurrence After Whipple’s study, a retrospective multicenter study of PD outcomes.
Results:
In total, 1,323 patients (89%) had data on their postoperative NS status available. Of these, 45% received postoperative NS, which was “enteral only,” “parenteral only,” and “enteral and parenteral” in 44%, 35%, and 21% of cases, respectively. Body mass index < 18.5 kg/m2 (p = 0.03), absence of preoperative biliary stenting (p = 0.009), and serum albumin < 36 g/L (p = 0.009) all correlated with receiving postoperative NS. Among those who did not develop a serious postoperative complication, i.e., those who had a relatively uneventful recovery, 20% received PN.
Conclusions
A considerable number of patients who had an uneventful recovery received PN. PN is not without risk, and should be reserved for those who are unable to take an oral diet. PD patients should undergo pre- and postoperative assessment by nutrition professionals to ensure they are managed appropriately, and to optimize perioperative outcomes.
5.Do some patients receive unnecessary parenteral nutrition after pancreatoduodenectomy?Results from an international multicentre study
Thomas B. RUSSELL ; Peter L. LABIB ; Paula MURPHY ; Fabio AUSANIA ; Elizabeth PANDO ; Keith J. ROBERTS ; Ambareen KAUSAR ; Vasileios K. MAVROEIDIS ; Gabriele MARANGONI ; Sarah C. THOMASSET ; Adam E. FRAMPTON ; Pavlos LYKOUDIS ; Manuel MAGLIONE ; Nassir ALHABOOB ; Hassaan BARI ; Andrew M. SMITH ; Duncan SPALDING ; Parthi SRINIVASAN ; Brian R. DAVIDSON ; Ricky H. BHOGAL ; Daniel CROAGH ; Ismael DOMINGUEZ ; Rohan THAKKAR ; Dhanny GOMEZ ; Michael A. SILVA ; Pierfrancesco LAPOLLA ; Andrea MINGOLI ; Alberto PORCU ; Nehal S. SHAH ; Zaed Z. R. HAMADY ; Bilal AL-SARRIEH ; Alejandro SERRABLO ; ; Somaiah AROORI
Annals of Hepato-Biliary-Pancreatic Surgery 2024;28(1):70-79
Background:
s/Aims: After pancreatoduodenectomy (PD), an early oral diet is recommended; however, the postoperative nutritional management of PD patients is known to be highly variable, with some centers still routinely providing parenteral nutrition (PN). Some patients who receive PN experience clinically significant complications, underscoring its judicious use. Using a large cohort, this study aimed to determine the proportion of PD patients who received postoperative nutritional support (NS), describe the nature of this support, and investigate whether receiving PN correlated with adverse perioperative outcomes.
Methods:
Data were extracted from the Recurrence After Whipple’s study, a retrospective multicenter study of PD outcomes.
Results:
In total, 1,323 patients (89%) had data on their postoperative NS status available. Of these, 45% received postoperative NS, which was “enteral only,” “parenteral only,” and “enteral and parenteral” in 44%, 35%, and 21% of cases, respectively. Body mass index < 18.5 kg/m2 (p = 0.03), absence of preoperative biliary stenting (p = 0.009), and serum albumin < 36 g/L (p = 0.009) all correlated with receiving postoperative NS. Among those who did not develop a serious postoperative complication, i.e., those who had a relatively uneventful recovery, 20% received PN.
Conclusions
A considerable number of patients who had an uneventful recovery received PN. PN is not without risk, and should be reserved for those who are unable to take an oral diet. PD patients should undergo pre- and postoperative assessment by nutrition professionals to ensure they are managed appropriately, and to optimize perioperative outcomes.