Nitration of isatin gives 5-nitroisatin (I). On boiling (I) with 5% formaldehyde solution for short periods of time, a compound was isolated which has been characterized as N-hydroxymethyl-5-nitroisatin (II). By the condensation of I (and II) with various H2N-B compounds, 17 derivatives (III-XIX) were formed. The structures of the obtained products were characterized by elemental analysis and IR spectroscopy. The synthesized compounds were tested for biological activities such as antibacterial activity on 9 strains of bacteria
isatinecic acid ; analogs & derivatives

3-[3,5-dichloro salicylamido] rhodanine was obtained by method dithiocarbamat. Condensation of 3-[3,5-dichloro salicylamido] rhodanine with p-dimethylaminobenzaldehyd, benzaldehyd, furfural, aldehyd salicylic to get four 5 -aryliden 3-[3,5-dichloro salicylamido] rhodanine. Condensation 3-[3,5-dichloro salicylamido] rhodanine with phenylhydrazin to get 2-phenyl hydrazon 3-[3,5-dichloro salicylamido] rhodanine. All of them were not seen in reference document. The structures of the obtained products were characterized by elemental analysis and IR spectroscopy. The results obtained on the test of antibiotic and antifungal activities showed that most of them had strong effect on tested bacteria Gram(+) and weak effect on bacteria Gram (-) and fungus.
Rhodanine ; Analogs & derivatives

Some unstable secodines 14, 16, 4, 5, stable hydrosecodines 13, 15 ,19, 20, 21, 22, 23 and aspidospermane type compounds 17,18, 9, 10, were prepared. Chemical properties of these compounds were studied by the transformation of stable secodine 13 into unstable secodines 4 and 5, result: vincadifformine 9 and 10 were generated.
Analogs & derivatives ; Alkaloids

The azometine derivatives of 5 nitrofurfural remain the biological activities of azometine beside of 5-nitrofurfural actives. Obtained 6 compounds which are crystals with certain melting point and content of elements as estimated formulation have anti fungal and anti microbial activities.
analogs & derivatives ; Pharmaceutical Preparations

From essential oil of turpentine, the author have been separated a-pinen. Some derivatives e.g pinonic acid, oxypinocamphon and benzyl pinonat have been syntherized. 7 derivatives such as oxime, hydrazone, semicarbazone, thiosemicarbazone, 2,4-dinitrophenyl hydrazone and isonicotinoyl hydrazone have been prepared
Chemical synthesis ; Analogs & derivatives

From the essential oil of turpentive, the author have separated pinene. Some derivatives e.g. pinonic acid, oxypinocamphon and n-propyl pinonat were synthesized. 7 derivatives such as hydrazone, semicarbazone, thiosemicarbazone, 2,4 dinitrophenyl hydrazone and isonicotionyl hydrazone were prepared. The structures of the obtained products were characterized by elemental analyses and spectral methods (IR, UV). The biological activities of the products such as antibacterial and antifungal were tested. The results indicated that these compounds possessed biological activities, especially antibacterial activity.
Chemical synthesis ; Analogs & derivatives

The authors have performed the condensation of Vanillin with following compounds: Hydrazone, semicarbazid, thiosemicarbazid, phenylhydrazine, 2.4 -dinitronphenyhydrazine and iso- nicotinoyl hydrazine. 6 compounds derivatives have been synthesized. The structures of the obtained products were characterized by spectral methods(IR,UV). The biological activities of the resulting products as antibacterial and antifungal have been tested. The results indicated these compounds possessed high biological activities, especially antibacterial activity.
Chemical synthesis ; Analogs & derivatives

3-thioxo-3-arylamido-4-oxo-1,3thiazan derivatives were obtained by method dithiocarbamat. Condensation of 2-thioxo-3-arylamido-4-oxo-1,3-thiazan derivatives with phenylhydrazin to get 2-thioxo-3-arylamido-4-phenylhydranzon-1,3-thiazan derivatives. The structures of the obtained products were determined by elemental analysis and IR spectroscopy. The study indicated that most of them had low antibacterial and antifungal activities.
Chemical synthesis ; Analogs & derivatives

The synthesis, structure elucidation and bio-activity of certain new 2-subtituted thiazole derivatives were reported. The newly prepared compounds were screened for their in vitro antibacterial and antifungal activities. The result revealed that almost compounds were active against fungi, 5 compounds were active against gram-positive bacteria. Meanwhile, 3 compounds had a remarkable both antibacterial and antifungal activities.
Thiazoles ; Analogs & derivatives

Condensing 2-amino-4-methyl-5-carbe thoxythiazole obtained from the cyclization process between thioure and ethylacetoacetate and oidine with some acylating agents to yield 9 new compounds of thiazole. All of them were screened for their invitro antibacterial and antifungal activities with respect to clotrimazol and cloramphenicol. The results showed that [2-(3,5-substuted salicylamido)-4-methyl-5-car-bethoxythiazole] compounds are active against gram-positive bacteria.
2-aminothiazole ; Analogs & derivatives