STAT3, as a member of signal transducers and activators of transcription (STATs) family,which has been recognized as one of the common pathways in cancer cells. STAT3 has been found in many tumor cells that are critical to cell survival, cell proliferation, invasion, angiogenesis and immune evasion.Thus, STAT3 signaling pathway may be a potential therapeutic target for tumor metastasis.

0.05) none of the 39 cases of small cell type was in the AB blood group

OBJECTIVE:To analyze the cost of three schemes in treatment of unstable angina pectoris METHODS:88 patients with unstable angina pectoris were divided into three groups:group Ⅰ was given isosorbide,asprin,nifedipine and nitroglycerin;group Ⅱ was given isosorbide,asprin,nifedipine,nitroglycerin and red sage injection and group Ⅲ was given isosorbide,asprin,nifedipine,nitroglycerin and puerarin;then using pharmacoeconomic method,cost-effectiveness analysis was carried out RESULTS:The efficacy in the group Ⅱ and group Ⅲ was higher than that in group Ⅰ(P0 05),and the E/C(effectiveness/cost) of the three groups were 15 98,18 02 and 33 40 respectively Compared with group Ⅰ,?C/?E of group Ⅱ and Ⅲ were 24 66,83 90 respectively;Compared with group Ⅱ,?C/?E of group Ⅲ was 643 60 CONCLUSION:The scheme for group Ⅱ is the best one

OBJECTIVE:To observe the hemostasis effect of combination of repilase and nitroglycerine against Emptysis.METHODS:90patients with Emptysis were randomly divided into treatment group and control group.The treatment group were treated with Reptilase together with nitroglycerine while the control group were treated with conventional hypophysin therapy.RESULTS:The total effective rate of hemostasis against hemoptysis was95.6%in the treatment group,which ex-celled the control group which has a total effective rate of66.7%.No significant adverse effect was found in the treatment group,which had a significant difference(P

Objective To investigate the effect and significance of cinobufagin on the expression of survivin of HHUA cells in the endometrial carcinoma cultured in vitro. Methods HHUA cells of endometrial carcinoma were cultured in vitro. After being intervened by cinobufagin with different concentration, the expression of survivin was measured by RT-PCR and the cellular apoptosis was tested by flow cytometry. Results In the control group: mRNA expression of survivin of HHUA cells in endometrial carcinoma was (1.22±0.23), cellular apoptutic rate was (2.31± 0.98)%; cinobufagin of 0.25 mg/ml didn't affect the survivin and cellular apoptotic rate (q=2.89, P>0.05: q=3.12, P>0.05) ; after being exposed to einobufagin of 2.5 mg/ml, the expression of survivin was (0.73± 0.26), and cellular apoptotic rate was (26.50± 6.36) %, with all of these data being different from the control group significantly (q=5.68, P<0.05; q= 10.23, P<0.05) ; the actions of cinobufagin of 25 mg/ml on mRNA expression of survivin and apoptotic rate were similar to cinobufagin of 2.5 mg/ml (q=3.49, P>0.05; q=4.35, P>0.05) . Conclusion Cinobufagin of 2.5 mg/ml inhibit the mRNA expression of survivin and proliferation of HHUA cells in endometrial carcinoma.

Biliary atresia(BA) is a destructive inflammatory obliterative cholangiopathy of neonates affecting both intrahepatic and extrahepatic bile ducts.BA is more common in east Asia.Genetic susceptibility,viral infections,and immune dysregulation may be related to BA,but immune dysregulation may play a key hole in the pathogenesis of BA.A current view of the pathogenesis of BA is that it may involve both a primary perinatal hepatobiliary viral infection and a secondary generation of an autoimmune-mediated bile duct epithelial injury.The etiology of BA is unknown,but there is evidence for the involvement of immunologic dysregulation mechanisms,which will be discussed in this review.

Ageing of population is now a phenomenon of the world and has considerable consequences for public services.Ageing is always accompanied with dysfunction of multiple organs,including hypothalamic-pituitaryadrenal axis.Here,we summarized alterations of hormone secretion of adrenal glands in the elderly and their relationships with Alzheimer' s disease.Moreover,we discussed characteristics of pheochromocytoma,primary aldosteronism,and Cushing's syndrome in the elderly.Lack of typical manifestations usually makes difficulty in diagnosis.

Objective To observe the effect of electroacupuncture(EA) on the profiles of hippocampal whole-genome expression in depression rats so as to study its underlying mechanism in relieving depression.Methods Thirty male SD rats were randomized into normal,model and EA groups(n=10/group).Depression model was established by chronic unpredictable stress stimulation(forced ice-water swimming,electric shock,tail-clamping,etc.) and lonely raising for 21 days.EA(2 Hz,1 mA) was applied to "Baihui"(GV 20) and "Yintang"(EX-HN 3) for 15 min,once daily for 7 days.The rats' ethological activities(horizontal and vertical movements) were detected with Open-field test in Morris labyrinth,and 1% sucrose solution consumption was detected.After termination of the treatment,the rats were killed and their hippocampal tissues were taken out for analyzing the whole-genome expression with Roche-NimbleGen chips(Rattus norvegicus 12?135 Karray).Results Compared with normal group,the distance of horizontal movement,rearing times,and sucrose consumption at day 21 and day 28 of model group decreased considerably(P

Laterally spreading tumor is a new type of colorectal tumor found recently.For its particular shape and develptment of tumor,LST is divided as an independent tumor.LST is associated with colorectal cancer and more research is done on it .The progress of its epidemiology, oncomolecularbiology, diagnosis and therapy is reviewed.

AIM:To establish an assay of oxymatrine and matrine in Compound Shiwei Tablets(Folium Pyrrosiae, Radix Sophorae Flavescentis, Radix Astragali, Herba Polygoni Avicularis, etc.) and Radix Sophorae Flavescentis by HPLC. METHODS: Diamonsil C 18 (10 ?m,250 mm?4.6 mm) analytical column was used.The mobile phase consisted of methanol-0.2% phosphoric acid solution (45∶55). The detection wavelength was 220nm. RESULTS : The average recoveries of oxymatrine and matrine in Compound Shiwei Tablets were 100.3% and 100.6% , respectively and in Radix Sophorae Flavescentis were 101.0% and 101.2%, respectlively. CONCLUSION: This method could be used for the quality evaluation of Compound Shiwei Tablets and Radix Sophorae Flavescentis.