Objective:To study the mechanism of apoptosis in hippocampus of the rats with disorder of cortical developments.Methods:The Rats with disorder of cortical developments were established by carmustine(BUCN).AT P0,P15,P30,P45,P60,the number of apoptosis cell and expression of Bax and Bcl-2 in hippocampus were detected by TUNEL,immunohistochemistry method and RT-PCR;then the detected outcomes were analyzed by computer micrograph analysis system in control group and model group.Results:At P15,P30,P45,P60,the numbers of apoptosis,Bax,Bcl-2 masculine cell and bcl-2 MRNA,bax MRNA in hippocampus in the model group were more than those in the control group.The ratio of Bax/Bcl-2 in model group was significantly higher than those in the control group(P

From Jeunary 1986 to June 1991 107 cases of carcinoma of stomach were found by gastroscopy, in which 100cases were proved pathologically by biopsy (93.5%).The biopsy of other 7 cases was negative and the diagnosis was confirmed lately by operation.gastroscopy and pathological characteristics and their clinical significane were discussed (103 cases of carcinoma of stomach cases of early stage carcinoma ventriculi case of pinpoint carcinoma).The authors suggested that ulcer, erosion, nodule and stiff surface on the depressed mucosa at the antrum be examined carefully by means of gastroscopy and biopsy be done in order to discover early stage carcinoma ventriculi and make a correct diagnosis.Being aware of these features in not only beneficial to the reasonable clinical treatmet but also helpful to the diagnosis of carcinoma of stomach.

Objective To investigate the different gender and untreated hyperthyroidism parameter difference (hyperthyroidism) and hemoglobin of red blood cells in peripheral blood of patients with relatively healthy people.Methods Collecting blood samples of patients with hyperthyroidism,with EDTA-K2 anticoagulant,using Sysmex XE-2100 automated hematology analyzer analysis of peripheral blood hemoglobin in red blood cell parameters and using healthy people as healthy control.Results Healthy control group,male,female red blood cells and hemoglobin in patients with hyperthyroidism were increased,the difference was statistical-ly significant (P <0.05).Conclusion Newly diagnosed hyperthyroidism value and erythrocyte hemoglobin values higher than nor-mal.

The migration of vascular endothelial cells plays an important role in the vascular growth, repair of wounds, and repair of vascular endothelial cells. At the same time, the migration of endothelial cells plays an important role in the progress of vascular diseases, especially atherosclerosis. Thus, the characteristics of endothelial cell migration and related factors are very important for us to understand the role of endothelial cells in the progress of physiology and pathology. In this article, the factors of promotion and inhibition, and blood flow, cytoskeleton and extracellular matrix are recommended in details. Furthermore, at the end of the article, we discuss the close relationship between endothelial cells and repair of vascular endothelial cells, even new vascular growth in the plaques of atherosclerosis.

Lung transplantation is now considered one of the effective management of end stage pulmonary diseases. This review presents the recent progress of primary graft failure in lung preservation, such as low temperature, ventilation, etc. The purpose is to provide some valid methods in clinical practice.

Objective: To establish a HPLC method for the determination of paeoniflorin in Zhuifeng Tougu pill. Methods: HPLC was used with C18 column,CH3OH-H2O(30 :70)as mobile phase and detection wavelength at 230nm. Results: Paeoniflorin showed a good linearity in the range of 21.02～210.20?g. The average recovery was 100.7%and RSD was 2.0%. Conclusion: This method is simple and accurate with good reproducibility, and can be used for the quality control of Zhuifeng Tougu pill.

The catabolic response to severe injury , burn, inflammatory ,acute pancreatitis and operation is characterized by whole-body protein loss, mainly reflecting increased breakdown of muscle proteins. Glucocorticoids and various proinflammatory cytokines are important regulators of muscle proteolysis in stressed patients. In recent years, three types of treatments have been used to reduce or prevent the catabolic response to injury and sepsis: ①nutritional, ②hormonal, and ③pharmacologic. This article review the catabolic response and the corresponding interruption under the stress conditions.

Three-dimensional (3D) reconstruction of medical images constructs the 3D models of organs using 2D medical image serials, which provide intuitionistic visual information for medical workers. However, most people concern about the CT images reconstruction, only few people focus on the reconstruction of Ultrasound images. In this thesis, it introduces Insight Segmentation and Registration Toolkit (ITK) and The Visualization Toolkit (VTK) firstly. Then it presents the process of Ultrasound image serials using ITK and VTK. At last, it presents the outcome of the experiment. The results show that the reconstruction of Ultrasound images can also get good effect by using ITK and VTK.

Animals ; Antigens, Neoplasm ; genetics ; metabolism ; Biomarkers, Tumor ; genetics ; metabolism ; Brain Neoplasms ; metabolism ; Cell Adhesion Molecules ; genetics ; metabolism ; Digestive System Neoplasms ; metabolism ; Female ; Genital Neoplasms, Female ; metabolism ; Glioma ; metabolism ; Head and Neck Neoplasms ; metabolism ; Humans ; Immunotherapy ; Male ; Prostatic Neoplasms ; metabolism ; Signal Transduction

Pharmacodynamic (PD) studies play an important role in research and development of new traditonal Chinese medicines (TCMs). Phamacologic and toxicologic studies that aim to research drug ability can provide supporting data for the clinical trials and reduce the risk of clinical trials. In recent years, PD studies in TCMs are developing and progressing, but there are still some problems affecting the value of PD studies in the development of new TCMs. The value of PD studies depends on scientific and rational study design. This article summaries some defects in PD study design of new TCMs that are common in the application data, including defects in study type, testing targets, dosing, duration of administration, control group, testing time. This article also discusses some points of concern and specific requirements for PD study design of new TCMs.
Humans ; Medicine, Chinese Traditional ; methods ; Pharmacokinetics