1.Effects of Radix Salviae Miltiorrhizae on the proliferation of vascular smooth muscle cells induced by plateletderived growth factor
Chinese Journal of General Surgery 2001;0(08):-
ObjectiveTo determine the effects of Radix Salviae Miltiorrhizae (RSM) on the proliferation of vascular smooth muscle cells(SMC) induced by plateletderived growth factor(PDGF).MethodsRat arterial SMC cultured in vitro were divided into the control group, RSM group (subdivided into 3 concentration groups:2.0mg/ml, 0.4mg/ml and 0.08mg/ml),PDGF group(10ng/ml) and PDGF(10ng/ml) plus RSM (the 3 concentrations the as the same as above) group. The number of SMC and 3HTdR incorporation of SMC were measured. Results PDGF induced the increases of the number of SMC and 3HTdR incorporation of SMC significantly, which were as 3fold and 2.5fold as those of the basic situation respectively. RSM,which was dosedependent, inhibited the increase of the number of SMC and 3HTdR incorporation of SMC in the basic and PDGF stimulated situations . ConclusionsRSM may inhibit SMC proliferation in the basic and PDGF stimulated situations.
10.A validation of the hospital anxiety and depression scale (HADS) in the medically-ill.
de Guzman Ma. Lourdes Rosanna E.
Acta Medica Philippina 2013;47(3):53-62
The underdiagnosis of depression and anxiety in the medical complications, improve compliance to treatment, and facilitate the "appropriate" use of health care resources.
OBJECTIVES: To determine the prevalence of depression and/or anxiety in the in-patient medically ill and to validate the Hospital Anxiety and Depression Scale (HADS) for Filipinos.
METHODS: To aid clinicians, the Hospital Anxiety and Depression Scale (HADS), a 14-item self-report questionnaire was validated in this cross-sectional study of 710 medically ill in-patients, to be able to determine how well it identified depression and anxiety against the criterion of a diagnostic psychiatric interview and to determine the optimal cut-off score of the HADS for Filipinos with the use of the Receiver Operating Characteristics (ROC).
RESULTS: The prevalence of depression was 26.9% anxiety was 14.3%, and the 'mixed diagnosis' of both was 13.7% among the medically-ill. The overall prevalence was 54.9%. The results showed that the optimal cut-off score for the HADS/ HADS-P is a score of 11, with a sensitivity of 75%, specificity of 70% and PPV of 75%.
CONCLUSION: The HADS/ HADS-P will provide clinicians with a reliable, valid and practical screening tool for identifying the two most common clinical problems in the medically ill, depression and anxiety. The HADS/ HADS-P can serve as a guide for clinicians towards the diagnosis of depression and anxiety, but it cannot be the sole basis for diagnosis.
Human ; Male ; Female ; Aged ; Middle Aged ; Adult ; Depression ; Self Report ; 4-amino-4'-hydroxylaminodiphenylsulfone ; Anxiety ; Anxiety Disorders ; Depressive Disorder ; Sensitivity And Specificity