The bachelor nursing education is an important period to cultivate high grade nursing talents.According to the existing issue in our college's anatomy teaching process,the article has explored the preliminary idea on the reform of course design for anatomy in bachelor nurse for discussion.

Objective To compare and analyze the effect of single PT (taxol,cisplatin) chemotherapy and the PT chemotherapy combined with Aidi injection in the medium and advanced esophageal patients,in order to maximize the strength chemotherapy' s effects,reduce the side effects,improve the patients' life qualities.Methods 106 cases of esophageal patients were randomly divided into two groups,53 patients for each group.The control group were treated by the single PT chemotherapy protocol,while the treatment group were combined with Aidi and PT chemotherapy protocol,21 days time peroid was taken as one circle.After two weeks,the effect,the patients' life qualities and the side effects between two groups were compared.Results The effective rates of treatment group and control group were 90.37 ％ (48/53) and 81.13 ％ (43/53),respectively,there was no statistic significance (P ＞ 0.05).The median-survival in two groups were 48 weeks and 42 weeks,which was statistic significance (P =0.027).The treatment group' s side effects incidence rate was lower than that of control group in Ⅲ-Ⅳ degree gastrointestinal reaction (Ⅲ degree P =0.026,Ⅳ degree P =0.027),Ⅲ-Ⅳ degree of inhibition of white blood cells (Ⅲ degree P =0.038,Ⅳ degree P =0.040),Ⅲ degree platelet inhibition (P =0.023) and Ⅱ-Ⅲ degree hypohemia (Ⅱ degree P =0.020,Ⅲ degree P =0.041).There were no statistically differences between treatment group and control group in liver,muscle,kidney toxicity and baldness (P ＞ 0.05).There were significant differences in Karnofsky score and body mass between pre-and post-treatment in chemotherapy group (P =0.067),but those in treatment group were not (P =0.006).Conclusion The Aidi injection combined with PT chemotherapy protocol has a better effect in the esophageal cancer patients,longer median survival time,reduced the side effects and improved the patients' life qualities,which is deserved to be used in the clinical furtherly.

Hyperplastic disease of the breast (HDB) is caused by a hormone imbalance experienced among women at a certain age. Slight breast pain is common in women before menstruation without need of treatment; however, if the pain becomes severe, it can cause physical and mental suffering. Therefore, it is of great clinical significance to control this disease.

Autophagy ; Cervical Cord ; injuries ; Humans ; Magnetic Resonance Imaging ; Spinal Cord Injuries ; complications ; diagnosis ; pathology

ObjectiveTo explore changes of the reacting force of the ankle joint (J) and the achilles tendon force (A) in the sagittal plane in a weight-bearing leg in a bout of the simplified-style Taijiquan exercise.MethodsJ and A determined from 30 healthy young males were analyzed using the simplified free body method.ResultsJ and A increased during exercise, J produced by movement 10, 14 and A produced by movement 8, 12 were about 2.4 times and 0.7 times body weight of 67.3kg respectively.ConclusionTaijiquan can increase the force of ligment and muscle around the ankle joint, especially that of triceps muscle of calf, and it is helpful for remaining the stability of the ankle structure.

ObjectiveTo explore the influence of slow and mild movements in Taichiquan kinesitherapy.MethodsForty healthy males were divided into Taichiquan group and walking group with 20 persons in each group. The shift of practicing a 5-min bout of the simplified Taichiquan exercise, time of walking 18 m at a comfortable pace and change of one person's body center of gravity during exercise were measured respectively.ResultsTaichiquan group had (1796.4±91)cm shift during 5 min Taichiquan exercise; walking group spent (14.1±1.7)s when walking 18 m at a comfortable pace; and the downward shift of body center of gravity due to the exercise style undulated ( 5.5 ±12.7)cm vertically below the umbilicus (P>0.05).ConclusionSlow, mild and continual movement is the kinesiological basis of Taichiquan kinesitherapy.

Intercellular adhesion molecule-1 (ICAM-1) is found in surface of cells in various tissues,which is a adhesion molecule with wide range of biological activity and plays an important role in inflammatory and immune response,signal transduction,tissue repair and many other physiological and pathological processes.In this paper,ICAM-1 expression and regulation in the body,as well as some actions in the pathogenesis of central nervous system diseases are reviewed.

OBJECTIVE: To prepare inclusion complex of SBE7-β-CD with trimethoprim(TMP) and optimize the preparation process, to evaluate the products by structural characterization and molecular simulation. METHODS: The TMP/SBE7-β-CD inclusion complex was prepared by the ultrasound-freeze-dry method and the preparation process was optimized by Box-Behnken Design-response surface method(BBD-RSM). Inclusion complex was characterized by FT-IR, DSC, XRPD and 1H-NMR. Molecular docking method was used to simulate 3-dimensional conformations of the inclusion complex and the binding energy was calculated. The dissolution and stability were tested. RESULTS: The optimum conditions of TMP/SBE7-β-CD inclusion complex were: temperature(52 ℃), time(45 min), and the ratio of SBE7-β-CD and TMP(mol/mol, 1.7∶1). All characterizations(FT-IR, DSC, XRPD and 1H-NMR) indicated the formation of TMP/SBE7-β-CD inclusion complex. The best 3-dimensional docking conformation was consistent with the characterizations, and the binding energy was -9.015 kcal·mol-1. The TMP dissolution rate of the inclusion complex increased significantly, the hygroscopicity is strong. CONCLUSION: The preparation process of TMP/SBE7-β-CD inclusion complex optimized by BBD-RSM is reasonable and feasible. The characterizations of inclusion complex are reliable. The molecular simulation is corresponded to the characterized results and provided reliable theoretical basis for inclusion experiments.

Objective To observe the imaging features of coronary sinus (CS) and its tributaries in Chinese by using multislice computed tomography (MSCT).Methods One hundred patients [74 men,26 women,average age (58.10?1.78)] were scanned by MSCT,3D images reconstructed and the vessels courses evaluated.Results The CS and great cardiac vein (GCV),middle cardiac vein (MCV) were visualized in all patients,as well as left posterior vein (LPV) was showed only in 82 patients.The average width of CS was (1.98?0.41),(1.08?0.06)cm,and the average area was (2.144?0.37)cm~2.The diameter of MCV was (0.49?0.04) cm and its angle with CS was (73.98?5.82)?.The GCV remained in the same axis as the CS in the left atrioventricular groove,its average diameter was (0.35?0.03)cm.The LPV's average diameter was (0.33?0.05)cm and its average angle with GCV was (74.32?7.81)?.The MCV and LPV in most of the patients drained to the CS at an angle less than 90?,and this angulation might cause technical difficulties during inserting a left ventricular pacing lead.Conclusion MSCT is a simple and feasible method to visualize the imaging features of CS and its main tributaries,and in the clinical,it can be used to evaluate patient's coronary vein system before cardiac interventional procedure such as left ventricular pacing lead implantation.