OBJECTIVE　To prepare the piroxicam films and study its characteristics of transdermal delivery.METHODS　Different high polymers were employed to prepare piroxicam films.Rat abdomen skin and modified Franz diffusion cells were used in the drug penetration tests and release tests.The percutaneous penetration rate was investigated.RESULTS　The release rate of piroxicam films was 64.31 μg*cm-2*h-1.The in vitro permeation rate was 14.86 μg*cm-2*h-1.The percutaneous penetration rate was 11.94 μg*cm-2*h-1.CONCLUSION　Piroxicam films was developed.

Objective To explore the efficiency of montelukast combined with alpha-interferon and budesonide in the treatment of children with upper respiratory tract infection.Methods According to the digital table,120 children with upper respiratory tract infection were randomly divided into the control group and the observation group,each group 60 cases.The control group was given anti-infection treatment,rehydration,controlling cough and other conventional treatment,and the observation group on the basis of the control group was given montelukast combined alpha-interferon,budesonide.The treatment course was 5d.The time of fever,coughing and wheezing disappeared and efficacy were compared between the two groups.Results The effective rate in the observation group was 80.0％,which was significantly better than that of the control group(53.0％) (χ2 =27.87,P ＜ 0.01).The total effective rate of the observation group was 95.0％,which had no significant difference with that of the control group (90.0％)(χ2 =1.92,P ＞ 0.05).The heating time and the cough last time of the observation group was (1.74 ± 0.75) h,(2.92 ± 0.56) h,respectively,which were significantly shorter than those of the control group [(2.82 ± 0.64) h,(4.13 ± 0.54)h] (t =3.142,3.143,all P ＜ 0.01).Conclusion Montelukast combined with alpha-interferon and budesonide in the treatment of children with upper respiratory tract infection is effective and safety,which has little adverse reactions and is worthy of promotion and clinical application.

Objective To investigate the effect of efficacious communication on easing mood in outpatients. Methods A review of outpatient service record in the period from January 2003 to November 2007 sum up and arrange the data in order to evaluate the emotion of outpatients with effective communication. Results The outpatients' complaint in the experiment group was significantly decreased than it of control group (P<0.01). Conclusion The important measure to prevent and reduce the outpatients' complaint was to develop the efficacious communication.

Objective To explore the relation between sealed tube method and retention time of intravenous catheter system . Methods Adopt direct injection seal-tube method, saline injection seal-tube method and heparin liquid seal-tube method with common intravenous catheter were adopted the intravenous catheter's retention time and incidence of phlebitis were observed. Results The retention time in direct injection seal-tube group and saline injec-tion seal-tube group respectively prolonged of 25.7% and 19. 3% compared with heparin liquid seal-tube group.There was significant difference (P < 0. 01 or P < 0. 05) through statistical analysis. But there was no significant differ-ence(P 0. 05) between direct injection seal-tube group and saline injection seal-tube group in retention time. Theincidence of phlebitis in both direct injection seal-tubo group and saline injection seal-tube group were below to the heparin liquid seal-tube group. There was significant difference(P 0. 05) in the three groups. But there was no sig-nificant difference(P 0. 05) between direct injection seal-tube group and saline injection seal-tube group in the inci-dence of phlebitis. Conclusion Direct injection seal-tube method and saline injection seal-tube method can signifi-cantly extend intravenous catheter's retention time and reduce the incidence of phlebitis.

Objective To study the effect of psychological factor in patients undergoing selective operation with preoperative interview by watching operation video. Methods 80 patients undergoing selective operation were divided equally into experimental group and control group randomly, the patients in experimental group accepted pre- operative interview with watching operation video, except for usual preoperative interview. The operation stress reac- tion could be identified by observation of change of blood pressure,pulse signal and emotion before operation. Results The emotion tensity in the experiment group was significantly lower than that of control group(P < 0.01 ). The blood pressure and pulse signal were significantly different between two groups(P < 0.05). Conclusion Application of preoperative interview with watching operation video helped patients to adopt to operation, more smoothly, to ele- vate the effect of operation and to boost the postoperative recovery.

0.05). conclusion; The frequency of A allele in essential hypertension is higher than that in control group, but there is no statistical significance. The relationship between AT2R gene A1675G polymorphism and essential hypertensive patients of the Chinese Han nationality population.

[Objective]To observe the therapeutic efficacy of Tripterygium wilfordi combined with Propylthiouracil in treating graves disease (GD).[Methods] 57 patients diagnosed GD were randomly classified into two groups.Both groups were given PTU for 1.5~2 years the treatment group added the drugs of Braun capsule,taking six consecutive months.[Results] The total efficiency of treatment group was 91.18percent,significantly higher than the control group (73.91%),had a significant difference (P

This study was aimed to carry out the research by statistics to analyze the influence of specific clinical function of Dioscorea opposita Thunb. from the viewpoint of prescription in order to summarize its rules. Formula containing D. opposita Thunb. in the classic book of the Formula Dictionary of Traditional Chinese Medicine were recorded. The prescription type of D. opposita Thunb. was taken as the mainline. Excellwas used in the chart analy-sis. The results showed that for the function of reinforcing spleen-stomach, the effect of powder was increased, but the effect of pill was reduced. For the function of reinforcing lung and generating essence, the effect of decoction was significantly increased, but the effect of pill was significantly reduced. For the function of reinforcing kidney-yin, the effect of pill was significantly increased, but the effect of decoction was reduced. For the function of strengthening the kidney and restraining yin, the effect of powder was reduced. It was concluded that preparation had a strong in-fluence on the clinical function of D. opposita Thunb., which provided references for both clinical practice and health cultivation.

This study was aimed to optimize extraction process of formula granules of Clematis chinensis Osbeck and establish its qualitative discrimination method. With oleanolic acid, hederagenin and extract rate as indexes, extraction technology conditions of formula granules of C. chinensis Osbeck were investigated by L9 (34) orthogonal test method. TLC was used in the qualitative discrimination of formula granules of C. chinensis Osbeck. The results showed that optimum extraction technology was: adding 12 times of water; soaking for 0.5 h; cooking for 1 h; and extracting for 3 times. TLC had the diagnostic characteristic for the distinct spot which illustrated the specificity. It was concluded that the extraction process was reasonable, simple and feasible with high extraction efficiency of ef-fective contents, which can be the scientific basis for production and quality control of formula granules of C. chin-ensis Osbeck.

This article was aimed to study on clinical application of Shanyao (Dioscorea opposita Thunb.) in each historical period, which can offer some suggestions for clinical doctors to use Shanyao correctly. A total of 668 pieces of formulae containing Shanyao were recorded from the classic format Dictionary of Traditional Chinese Medicine Formula. And then, statistic analysis was made on the emerging frequency according to its effect. The results showed that different effects of Shanyao started to be widely applied from the Song dynasty. It was most widely applied in the Ming and Qing dynasty. Nowadays, the difference between using Shanyao has been gradually decreased. During the whole historical period, clinical functions of Shanyao are mainly reinforcing the spleen and the stomach, tonifying the kidney and strengthening yin. However, clinical functions of reinforcing the kidney and restraining yin, tonifying the lung and promoting fluid are used secondly. It was concluded that the research analyzed clinical application of Shanyao in each historical period, which can offer scientific basis for clinical practice and health maintenance with the using of Shanyao.